Medicube PDRN Pink Peptide Ampoule for dry skin
Salmon Pdrn
Salmon Collagen Complex
UbiquinoneAverage
- HighDry Skin Fit
- AverageEffectiveness
- HighSafety
Works for dry skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your dry skin, as Hyaluronic Acid and Salmon Collagen Complex provide essential hydration and emollient actions, though it is not specialized for flakiness.
- Niacinamide and Ubiquinone offer general skincare benefits that support overall skin health.
- The formula is safe for your dry skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
People Say
★4.7Overall rating based on 2.5k+ reviewsBased on a very large amount of data, users consistently report that this ampoule delivers a "glass skin" effect, providing deep hydration and a noticeable plumping effect that benefits dry and aging skin. While it is widely praised for smoothing texture and soothing sensitive skin, results regarding blemish fading are mixed and take longer to appear.
Highlights
Deep hydration Mostly Mentioned
- “skin feels bouncier”
- “deeply moisturized from within”
- “plump and radiant”
- “eliminated deep dryness”
Radiant glow Mostly Mentioned
- “glass skin glow”
- “healthy dewy look”
- “complexion looks clearer”
- “natural inner glow”
Fast absorption Often Mentioned
- “absorbs quickly”
- “no greasy residue”
- “lightweight formula”
- “glides onto skin beautifully”
Noticeable fragrance Sometimes Noted
- “strong rosy scent”
- “smell isn't my thing”
- “wish it was fragrance-free”
- “scent is polarizing”
Small volume Sometimes Noted
- “runs out quickly”
- “30ml is too small”
- “pricey for the size”
- “wish they offered a larger version”
Soothing and gentle Sometimes Noted
- “no irritation”
- “calmed redness”
- “good for sensitive skin”
- “gentle and soothing”
Minor breakouts Rarely Noted
- “small pimple appeared”
- “caused blemishes on chin”
- “broke me out slightly”
- “congestion on forehead”
Slight stickiness Rarely Noted
- “tacky film”
- “slight sticky feeling”
- “residue left behind”
- “hair sticks to face”
Sources: lovi.care, oliveyoung.com, yesstyle.com, hwahae.co.kr, amazon.co.uk, youtube.com, and more
Questions and answers
How well does medicube PDRN Pink Peptide Ampoule work for dry skin?
This product is an average fit for dry skin, providing essential hydration through hyaluronic acid and salmon collagen complex, though it is not specialized for flakiness. To work best for dry skin, a product of this type needs richer hydrating ingredients like multiple forms of hyaluronic acid, ceramides, and pro vitamin B5 to effectively support the skin barrier and lock in moisture.
Which ingredients make this serum a good fit for dry skin?
Hyaluronic Acid and Salmon Collagen Complex make this serum a good fit for dry skin because they provide essential hydration and softness. To work best for dry skin, this type of product needs ingredients that enhance moisture retention and support the skin barrier, such as ceramides, multiple forms of hyaluronic acid, and nourishing extracts.
What does Salmon Pdrn do for dry skin?
Salmon PDRN helps dry skin by improving skin barrier function and hydration. It supports tissue repair and recovery, making it useful for restoring a smooth and healthy feel.
Frontiers in Pharmacology, 2017Journal of Cosmetic Dermatology, 2025
What does Salmon Collagen do for dry skin?
Salmon collagen helps boost skin moisture and keeps dry skin feeling soft and smooth. Studies show that taking collagen peptides regularly may improve hydration and help reduce dryness over a period of weeks.
Journal of Cosmetic Dermatology, 2015Journal of the Science of Food and Agriculture, 2016
Where does this serum go in a skincare routine for dry skin?
This treatment goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. A dry skin routine like this works best when it also includes a specialized rich cream or oil to tackle flakiness and lock in lasting moisture.
Can I use this serum with retinol, and in what order?
You can use this moisturizing treatment with retinol by applying the treatment before your retinol product to help keep your dry skin hydrated. This product is safe to use with other actives because it contains gentle, hydrating ingredients like Hyaluronic Acid, though dry skin generally needs richer ingredients to properly soothe flakiness.
How often should I use this serum?
You can use this treatment in your evening routine, as this ampoule fits your dry skin moderately well. Because it lacks specialized flakiness care, dry skin of this type needs richer hydrating ingredients and skin-softening oils to feel completely smooth and comfortable.
Health Science Reports, 2021Journal of Cosmetic Dermatology, 2020
Can this serum clog pores, cause breakouts or purging for dry skin?
This serum is unlikely to clog pores or cause breakouts on dry skin, as its formula contains no harsh or irritating ingredients. However, because it offers only moderate hydration, dry skin often needs richer ingredients like ceramides and heavier butters to truly stay soft and comfortable.
Can I use this serum around the eyes or on my body?
You can use this moisturizing treatment around the eyes and on your body since its gentle formula is safe and unlikely to cause irritation. Because the skin around the eyes and on certain body areas is particularly thin, this product's hydrating and nourishing ingredients help support and protect it well.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Topical treatment with coenzyme Q10 formulas replenishes Q10 levels in the skin surface and deeper epidermis, augments cellular energy metabolism, and reduces free radicals while increasing antioxidant capacity in stressed skin.
BioFactors, 2015Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism.
BioFactors, 2008Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.
International Journal of Molecular Sciences, 2025Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.
Molecular Medicine Reports, 2023A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.
Molecules, 2022Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine sponge collagen extract formulations increased skin lipids significantly while having no noticeable influence on skin surface pH and only slightly increasing skin hydration.
European Journal of Pharmaceutics and Biopharmaceutics, 2002Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects.
Colloids and Surfaces. B, Biointerfaces, 2023Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects.
Antioxidants, 2021Topical application of CoQ10-formulated products reduces the depth of cutaneous wrinkles and replenishes skin antioxidant levels by stimulating cutaneous energy metabolism and providing antioxidant effects in aging and stressed skin.
The Journal of Clinical and Aesthetic Dermatology, 2024
Why other moisturizers fit dry skin better
Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.
Arzneimittel-Forschung, 2000A formulation containing glycerol (5%) and xylitol (5%) applied twice daily for 14 days increased skin hydration, filaggrin protein quantity, interdigitation index, and biomechanical properties, and decreased transepidermal water loss compared to untreated and vehicle-treated skin in twelve volunteers with dry skin.
Acta Dermato-venereologica, 2017Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002
Ingredients
Salmon Pdrn, Salmon Collagen Complex, Ubiquinone, Ocimum Tenuiflorum, Hyaluronic Acid, Niacinamide, Curcuma Longa Root Extract, Adenosine, Ocimum Sanctum Leaf Extract, Peptide Complex, Rose Pdrn Extract Rosa Damascena Sodium Dna Extract
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.