DRMTLGY Peptide Night Cream for acne-prone skin
Peptides
Ceramides
Shea Butter
Tocopherol Vitamin E
Allantoin
Average
- AverageCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for acne-prone skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your combination skin, as ceramides and peptides enhance barrier resilience and glycerin provides hydration, but it lacks targeted ingredients for your acne and blemishes.
- Shea butter offers emollient actions, which are supportive for acne-prone skin, but the formula does not provide sufficient ingredients for optimal oil control.
- The safety profile is excellent, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
People Say
★4.9Overall rating based on 2.4k+ reviewsBased on a very large amount of data, this fragrance-free night cream is highly regarded for its rich yet non-greasy texture, providing deep hydration and plumping effects. Users frequently report improvements in skin texture, reduced fine lines, and a strengthened moisture barrier, making it suitable for sensitive and aging skin types. Some users find the jar packaging unhygienic, and a few with very dry skin may require additional moisture, while others note it can be too heavy for daytime use. Availability can also be a concern due to frequent sell-outs.
Highlights
Deep hydration Mostly Mentioned
- “quenches skin's thirst”
- “woke up glowing”
- “no more dry patches”
Gentle formula Often Mentioned
- “no irritation”
- “fragrance-free”
Non-greasy texture Often Mentioned
- “soaks right in”
- “fluffy texture”
- “lightweight but rich”
Anti-aging benefits Sometimes Noted
- “softens fine lines”
- “skin looks younger”
- “improves skin elasticity”
Value for money Sometimes Noted
- “better than high-end”
- “great price point”
- “affordable luxury”
Jar packaging Sometimes Noted
- “wish it had a pump”
- “don't like dipping fingers”
- “prefer airless dispenser”
Availability issues Rarely Noted
- “shipping takes time”
- “only available online”
- “sold out frequently”
Not rich enough Rarely Noted
- “need to layer oil”
- “not enough for winter”
- “dried out by morning”
Too heavy for day Rarely Noted
- “too thick for day”
- “shiny under makeup”
- “strictly a night cream”
Sources: lovi.care, drmtlgy.com, amazon.com, reddit.com, youtube.com, makeupalley.com, and more
Questions and answers
How well does DRMTLGY Peptide Night Cream work for acne-prone skin?
This cream works moderately for acne-prone skin because it hydrates and strengthens the skin barrier with glycerin and ceramides, but it lacks targeted ingredients for breakouts and oil control. Acne-prone skin needs a moisturizing treatment that provides effective ingredients for blemishes and breakouts alongside soothing agents and hydration.
Which ingredients make this cream a good fit for acne-prone skin?
Ceramides, peptides, and glycerin make this cream a good fit by strengthening the skin barrier and providing hydration, while shea butter offers softening benefits. However, because acne-prone skin needs more, this type of product also requires targeted ingredients for oil control and blemishes.
What do Peptides do for acne-prone skin?
Peptides help calm acne-prone skin by reducing redness and soothing inflammation while supporting the skin barrier. Certain advanced peptide formulas also work to target acne-causing bacteria and help balance oil production.
Biochemical Pharmacology, 2025Bioresources and Bioprocessing, 2026
What do Ceramides do for acne-prone skin?
Ceramides help acne-prone skin by restoring a damaged water barrier, reducing dryness and redness from acne treatments, and lowering inflammation. Because acne-prone skin often lacks these key fats, products for this skin type need ceramides to soothe irritation and keep the barrier strong.
Journal of Drugs in Dermatology, 2023Archives of Dermatological Research, 1995
Where does it go in a skincare routine for acne-prone skin?
This product goes in the evening routine as a moisturizing treatment after your cleanser and toner. For acne-prone skin, this cream works well enough, but it lacks targeted ingredients for blemishes, so this skin needs added blemish-fighting ingredients and oil-control components.
Can I use this cream with retinol, and in what order?
You can use this cream with retinol by applying your retinol first and following it with this moisturizer. This helps keep your skin soft while managing dryness, though acne-prone skin needs a product that also provides targeted oil control and blemish-fighting ingredients.
How often should I use it?
You can use this moisturizing treatment twice daily to help keep your skin hydrated and support your skin barrier. This product is unlikely to irritate your skin, though acne-prone skin needs a product with targeted ingredients for blemishes and oil control.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for acne-prone skin?
This cream is unlikely to cause irritation or breakouts since it lacks harsh ingredients, but it does not provide enough oil control for acne-prone skin. Acne-prone skin works best with products that offer targeted blemish control and oil-balancing ingredients.
Can I use it around the eyes or on my body?
This cream is safe to use around the eyes and on the body, as it has a very gentle formula with no harsh ingredients. However, because the skin around the eyes is very thin and body skin is thicker, you may want to choose products specifically designed for those areas to get the best results.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.
Lasers in Medical Science, 2025A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.
International Journal of Cosmetic Science, 2025Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.
Aesthetic Plastic Surgery, 2018
Why other moisturizers fit acne-prone skin better
Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.
Journal of Cosmetic Dermatology, 2022
Ingredients
Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter Shea Butter, Caprylic Capric Triglyceride, Cetyl Alcohol, Dimethicone, Peg-100 Stearate, Ceramide Eop, Ceramide Ap, Palmitoyl Tetrapeptide-7, Ceramide Np, Palmitoyl Tripeptide-1, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Allantoin, Phytosphingosine, Cholesterol, Tridecane, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Glycol Distearate, Ethylhexylglycerin, Potassium Cetyl Phosphate, Carbomer, Sodium Hydroxide, Disodium Edta, Sodium Lauroyl Lactylate, Polysorbate 20, Dextran, Xanthan Gum, Phenoxyethanol, Magnesium Chloride
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.