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Mandelic acid and hexapeptide-9

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Mandelic acid and hexapeptide-9: keep them apart

Keep them apart

Apply mandelic acid and hexapeptide-9 at different times of day because the acid destroys the peptide's firmness benefits. Mandelic acid makes your skin too acidic, which breaks down hexapeptide-9 and stops it from smoothing fine lines. You can use one in the morning and the other at night to get the best results from both.

Mandelic acid products

Hexapeptide-9 products

Questions and answers

Can you use mandelic acid and hexapeptide-9 together?

No, you should keep mandelic acid and hexapeptide-9 apart in your routine because the acidic environment of mandelic acid can destabilize peptide bonds and reduce their effectiveness. Instead, use them in separate steps or routines, such as applying mandelic acid in the morning and hexapeptide-9 at night.

Which goes first, mandelic acid or hexapeptide-9?

Keep mandelic acid and hexapeptide-9 apart by using them in separate routines, such as AM and PM, because the low pH of mandelic acid may break down peptide bonds and reduce the effectiveness of hexapeptide-9.

Are mandelic acid and hexapeptide-9 good for sensitive skin?

Mandelic acid and hexapeptide-9 should be kept apart in your routine because the acidic environment of the acid may destabilize the peptide bonds. Use them in separate steps or different routines like AM and PM separation.

Research on mandelic acid and hexapeptide-9

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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