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Azclear vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Azclear and Sesderma are carefully balanced skincare lines known for their advanced serums, soothing formulas, and targeted active ingredients. Azclear suits sensitive, acne-prone, and reactive skin types best, featuring its Medicated Lotion, while Sesderma suits sensitive, hyperpigmented, and aging skin types best, featuring its Azelac RU Serum. Both brands offer thoughtful formulations that work to gently nurture and balance the complexion, but they differ in their specific botanical extracts and active compounds designed to refine skin texture and promote radiance.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Azclear and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Azclear vs Sesderma products

Azclear vs Sesderma serums and treatments

Questions and answers

Azclear or Sesderma: which is better?

Azclear Medicated Lotion has a High fit for oily acne-prone skin, while Sesderma Azelac RU Serum has a High fit for acne-prone skin, skin with dark spots, and combination skin. Azclear lists no fragrance in its ingredients, whereas Sesderma includes fragrance in its serum.

Pharmaceutics, 2021

What is the difference between Azclear and Sesderma?

Azclear products on this page have no fragrance, whereas the Sesderma product includes fragrance. For oily acne-prone skin, Azclear achieves a High Lovi fit level while Sesderma has an Average fit level.

Which is more affordable, Azclear or Sesderma?

The provided page facts do not contain pricing information, so it is not possible to determine whether Azclear or Sesderma is more affordable based on this page.

Which causes fewer breakouts, Azclear or Sesderma?

Azclear Medicated Lotion achieves a High Lovi fit for oily acne-prone skin, while Sesderma Azelac RU Serum reaches a High fit for acne-prone skin. Both brands on this page help manage breakouts.

Pharmaceutics, 2021

When were Azclear and Sesderma founded, and who owns them?

Azclear was founded in 2010 and is owned by Ego Pharmaceuticals, while Sesderma was founded in 1989 in Spain and is owned by Grupo Sesderma since 2026.

Do Azclear products contain fragrance compared to Sesderma products?

Every product on this page by Azclear lists no fragrance in its ingredients, whereas the Azelac RU Serum by Sesderma includes fragrance.

Which brand offers a serum better suited for skin with dark spots?

For skin with dark spots, Sesderma offers a better-suited serum because its Azelac RU Serum has a High Lovi fit level compared to the Average fit of Azclear Medicated Lotion. Additionally, Azclear lists no fragrance in its products, while Sesderma includes fragrance in its serum.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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