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Vitamin C and hexapeptide

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Vitamin C and hexapeptide: depends on the strength

Depends on the strength

Apply vitamin C in the morning and hexapeptide at night because mixing them reduces their effectiveness. They cancel each other out so your skin misses out on the full benefits. You can use them at different times of day or wait a few minutes between applications.

Microneedle-Mediated Delivery of Copper Peptide Through Skin

Vitamin C products

Hexapeptide products

Questions and answers

Can you use vitamin C and hexapeptide together?

Whether you can use vitamin C and hexapeptide together depends on the strength. You should avoid or separate traditional vitamin C and copper-containing hexapeptides in the same routine, while pH-tolerant peptide derivatives may pair well with vitamin C.

Which goes first, vitamin C or hexapeptide?

You should use vitamin C and hexapeptides in separate routines depending on the strength, because combining them can cause copper complexes to oxidize and reduce the peptide's effectiveness. Alternatively, you can use pH-tolerant peptide derivatives that pair well with vitamin C.

Are vitamin C and hexapeptide good for sensitive skin?

Using vitamin C and hexapeptides together depends on the strength of the ingredients, as pure L-ascorbic acid and copper peptides should be avoided or separated in your routine. However, pH-tolerant peptide derivatives pair well with vitamin C and may benefit mature and sensitive skin.

Research on vitamin C and hexapeptide

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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