Acetyl hexapeptide-3 and zinc sulfate

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Keep them apart

Use them at different times of day, applying the peptide first, because they cancel each other out. Zinc blocks the peptide from working, meaning the shopper gets no anti-aging benefits. The shopper can use zinc in the morning and peptides at night.

Acetyl hexapeptide-3 products

The Ordinary Multi-Peptide + Copper Peptides 1% Serum €27.95
The Ordinary Multi-Peptide + HA Serum €16.90
Medik8 Liquid Peptides €102.00
La Mer The Treatment Lotion €79.90
Rhode Peptide Glazing Fluid
The Ordinary Argireline Solution 10% €8.96
Good Molecules Super Peptide Serum €23.20
Clinique Smart Clinical Repair Wrinkle Correcting Serum €71.30
La Mer The Renewal Oil €189.00
Estée Lauder Micro Essence Treatment Lotion €109.00
The INKEY List Collagen Peptide Serum
La Mer The Eye Concentrate €124.58

Zinc sulfate products

Bioderma Sébium Gel moussant €21.34
Vichy Normaderm Phytosolution €17.25

Questions and answers

Can you use acetyl hexapeptide-3 and zinc sulfate together?

Keep acetyl hexapeptide-3 and zinc sulfate apart in your routine because zinc sulfate is an unchelated metal ion that may complex with peptides and reduce their biological activity.

Which goes first, acetyl hexapeptide-3 or zinc sulfate?

Keep acetyl hexapeptide-3 and zinc sulfate apart in your routine because zinc sulfate is an unchelated metal ion that may bind with the peptide and reduce its activity. Apply them at different times of the day to ensure each ingredient works effectively.

Are acetyl hexapeptide-3 and zinc sulfate good for sensitive skin?

Keep acetyl hexapeptide-3 and zinc sulfate apart in your routine because zinc sulfate may reduce the activity of acetyl hexapeptide-3. Lovi rates this combination as Average for all skin types.

Research on acetyl hexapeptide-3 and zinc sulfate

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-3 · Annals of Dermatology, 2019
The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

Nadia Kapleva, MS

Co-founder, Medical Director

Cosmetic chemist, cosmetologist, aesthetic products developer
Alexey Shagraev, PhD

Co-founder, CEO and CTO

PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
Dr. Sofía Perea Pérez, MD, MSc

Medical Board

Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
Aishani Shah, MD

Medical Board

Specialist dermatologist, MBBS, MD, IFAAD
Asya Zubkova, MS

Medical Board

Cosmetic chemist, SCS, IFSCC member
Hanna Kurets, MD

Medical Board, Medical Advisor

Dermatology MD
Elina Nazarenko, MD

Medical Board

Dermatology and diagnostic consultant
Victoria Derkova, MS

Medical Board

Cosmetic chemist, cosmetic development technologist

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