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Olay Regenerist Regenerating Serum for oily acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Olay Regenerist Regenerating Serum

High

  • HighOily Skin Fit
  • HighEffectiveness
  • HighSafety

A great choice for oily acne-prone skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers high suitability for your oily skin due to niacinamide's seboregulation and humectant properties, complemented by glycerin for hydration, though its primary benefits are supportive rather than directly targeting acne and blemishes.
  • The presence of palmitoyl pentapeptide-4 and niacinamide aids in smoothing texture and minimizing fine lines, providing general skincare advantages.
  • The formula is safe for your oily skin, with no risks of irritation from harsh or prohibited ingredients.

How to apply

  • Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
  • Apply your serum after cleansing and toning, but before putting on your moisturizer.
  • Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
  • Apply the serum on clean, dry skin to help manage your blemishes safely.
  • Do a patch test before your first use and avoid the delicate eye area.

People Say

★4.5Overall rating based on 1.0k+ reviews

Based on a very large amount of data, users love this serum's lightweight, silky texture that absorbs quickly, making it ideal for layering. Many report softer, hydrated skin and a reduction in fine lines, contributing to a smoother appearance. A small number of users experienced breakouts or found the texture sticky.

Highlights

  • Effective hydration Mostly Mentioned
    • “My skin feels so hydrated and plump.”
    • “It's very moisturizing without being heavy.”
    • “Leaves my skin feeling soft.”
  • Silky texture Mostly Mentioned
    • “Absorbs so quickly!”
    • “Feels like silk on my skin.”
    • “Doesn't feel greasy at all.”
  • Convenient packaging Sometimes Noted
    • “The pump dispenser is hygienic and easy to use.”
    • “Great for travel, doesn't leak.”
    • “Easy to get the right amount of product.”
  • Fragrance-free option Sometimes Noted
    • “No strong scent, which is great for my sensitive skin.”
    • “I didn't react to the fragrance.”
    • “Good for people who dislike perfumed products.”
  • Visible results Sometimes Noted
    • “I've noticed a difference in my fine lines.”
    • “My skin looks brighter and healthier.”
    • “It gives a nice glow.”
  • Ingredient concerns Rarely Noted
    • “Contains parabens which I try to avoid.”
    • “Has silicones that feel heavy.”
    • “Worried about the preservatives.”
  • Packaging flaws Rarely Noted
    • “The pump stopped working after a week.”
    • “Couldn't get all the product out.”
    • “The bottle is hard to use up.”
  • Skin reactions Rarely Noted
    • “Broke me out in cystic acne.”
    • “Caused a rash all over my face.”
    • “I got small bumps after using it.”
  • Texture issues Rarely Noted
    • “Felt sticky on my skin.”
    • “Pilled when I applied makeup over it.”
    • “Left a tacky residue.”
  • Value for money Rarely Noted
    • “It's quite expensive for the amount you get.”
    • “I went through the bottle too fast.”
    • “Not great value for a drugstore serum.”

Sources: lovi.care, walmart.com, target.com, ulta.com, faceserum.com, youtube.com, and more

Questions and answers

What makes Olay Regenerist Regenerating Serum a great fit for oily acne-prone skin?

Olay Regenerist Regenerating Serum is a great fit for your oily acne-prone skin because niacinamide helps balance oil, while glycerin provides lightweight hydration without clogging pores. The formula also smooths texture with peptides and is very safe, as it avoids harsh ingredients that might cause irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017Journal of Cosmetic Dermatology, 2021

Which ingredients make this serum a good fit for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because niacinamide helps balance oil while glycerin delivers hydration without heaviness. Palmitoyl pentapeptide-4 and niacinamide also smooth your texture and soften fine lines, and the formula is unlikely to cause irritation.

Journal of Cosmetic Dermatology, 2021Clinical, Cosmetic and Investigational Dermatology, 2017

What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.

Journal of Cosmetic and Laser Therapy, 2006Journal of Cosmetic Dermatology, 2024

What does Palmitoyl Pentapeptide-4 do for oily acne-prone skin?

Palmitoyl Pentapeptide-4 helps smooth fine lines and improves the look of aging skin, but it is not specifically formulated to treat acne. For oily, acne-prone skin, a product of this type needs added ingredients that clear pores and calm redness.

International Journal of Cosmetic Science, 2005

Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in your evening routine, applied after cleansing and toning and before your moisturizer. Putting it in the evening keeps things simple and helps protect your skin from the sun.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to keep your skin hydrated while it adjusts to the retinol. This formula is safe for oily skin and is unlikely to cause irritation.

How often should I use this serum?

You can use this treatment in your evening routine, as treatments with active ingredients are typically placed at night for simplicity and extra safety around sun exposure. Some serums can also be used in the morning or twice a day if your skin tolerates them well.

Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for your oily acne-prone skin because it has a safe formula with a low risk of skin reactions. It also contains ingredients like tocopheryl acetate that help keep skin clear and balanced.

Contemporary Clinical Trials Communications, 2021

Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects.

    International Journal of Cosmetic Science, 2005

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

    Scientific Reports, 2024

  • Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

    Contemporary Clinical Trials Communications, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

    Journal of Cosmetic and Laser Therapy, 2006

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

  • Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

    Journal of Cosmetic Dermatology, 2025

  • Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

    Journal of Cosmetic Dermatology, 2024

  • A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use.

    Journal of Cosmetic Dermatology, 2022

  • Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.

    Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016

  • A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.

    Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

  • An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.

    Aesthetic Plastic Surgery, 2018

Ingredients

Water, Dimethicone, Glycerin, Niacinamide, Dimethicone Crosspolymer, Polymethylsilsesquioxane, Panthenol, Polyethylene, Palmitoyl Pentapeptide-4, Sodium Peg-7 Olive Carboxylate Oil, Tocopheryl Acetate, Allantoin, Camellia Sinensis Leaf Extract, Dimethiconol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Dmdm Hydantoin, Iodopropynyl Butylcarbamate, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, C13-14 Isoparaffin, Aminomethyl Propanol, Laureth-4, Laureth-7, Disodium Edta

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play