Obagi Kinetin+ Hydrating Cream for acne-prone skin

How to apply

Questions and answers

What the research says

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• Kinetin treatment increased involucrin and keratin 1 mRNA expression in HaCaT cells and improved skin moisture and transepidermal water loss while decreasing skin texture roughness in subjects using kinetin-containing cream compared to baseline.

  Annals of Dermatology, 2017

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• Topical combination of kinetin and niacinamide exerts synergistic anti-aging effects with significant reductions in spot, pore, wrinkle, and evenness counts, alongside increased hydration and decreased erythema in Taiwanese subjects compared to placebo.

  Journal of Cosmetic Dermatology, 2007

• Cosmetic formulations containing a liposomal dispersion of magnesium ascorbyl phosphate, alpha-lipoic acid, and kinetin provided photoprotection against UV damage in hairless mouse skin and enhanced stratum corneum and deeper layer skin moisture in human volunteers after four weeks of daily applications.

  Photochemistry and Photobiology, 2012

• Topical 0.1% kinetin cream applied twice daily for 12 weeks resulted in slight but statistically significant improvements in overall skin condition, texture, color, and wrinkles among 100 Thai subjects with facial photo-damage compared to baseline.

  Indian Journal of Dermatology, Venereology and Leprology, 2015

• N6-benzyladenine and kinetin stimulated antioxidative enzyme activity, reduced glutathione, and thiol group content while decreasing membrane phospholipid peroxidation and malondialdehyde production in human skin fibroblasts in vitro.

  Molecular and Cellular Biochemistry, 2016

• Pretreatment with trans-Zeatin significantly inhibits UVB-induced MMP-1 expression, c-Jun activation, and MAPK phosphorylation in cultured human skin fibroblasts compared to UVB irradiation alone.

  International Journal of Molecular Medicine, 2009

• Long-term treatment with zeatin in human skin fibroblasts undergoing aging in vitro prevented cell enlargement, reduced intracellular debris, prevented actin polymerization, and enhanced stress tolerance without increasing maximum proliferative capacity.

  Rejuvenation Research, 2005

• Trans-Zeatin treatment attenuates ultraviolet-induced aquaporin-3 loss, delayed wound healing, and decreased water permeability in cultured human skin keratinocytes through the inhibition of MEK/ERK activation.

  International Journal of Molecular Medicine, 2010

• A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.

  Clinical Pharmacology, 2018

• Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief.

  Plastic and Reconstructive Surgery, 2018

• Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo.

  Journal of Alternative and Complementary Medicine, 2010

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical application of a 0.1% copper-zinc malonate-containing cream significantly enhanced elastin biosynthesis and induced elastic fibre regeneration in photoaged facial skin of 21 female patients after 6 weeks of treatment compared to baseline.

  Experimental Dermatology, 2009

• A betaine-based deep eutectic solvent successfully enhanced the transdermal delivery of elastin peptide, which improved skin barrier repair, reduced melanin secretion and deposition, and stimulated the secretion of procollagen I and elastin.

  Biomaterials Advances, 2024

• Bioactive recombinant humanized elastin (RHE) gel effectively restores skin elasticity, reverses UV-induced damage and oxidative stress, and promotes extracellular matrix remodeling in zebrafish and aged mice models compared to commercial vitamin E and recombinant humanized collagen gels.

  Materials Today. Bio, 2025

Why other moisturizers fit acne-prone skin better

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.

  Journal of Cosmetic Dermatology, 2022

Ingredients

Water, Glyceryl Stearate, Propylene Glycol, Octyldodecyl Myristate, Stearic Acid, Cetyl Alcohol, Peg-12 Glyceryl Dimyristate, Stearyl Alcohol, Lactobacillus Ferment, Glycine Soja Soybean Sterols, Phenoxyethanol, Laureth-23, Dimethicone, Carbomer, Tocopheryl Acetate, Ethoxydiglycol, Sodium Hydroxide, Ethylhexylglycerin, Kinetin, Zeatin, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Disodium Edta, Panthenol, Citric Acid, Ascorbic Acid, Hydrolyzed Elastin, Water-Soluble Collagen, Aloe Barbadensis Leaf Juice, Hydrochloric Acid

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.