Medicube Zero Pore Pad for mature skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport.

  Biomaterials Advances, 2022

• Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability.

  Journal of Cosmetic Dermatology, 2024

• Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin.

  Cutis, 2004

• Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties.

  Journal of the American Academy of Dermatology, 1992

• A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins.

  The Journal of Clinical and Aesthetic Dermatology, 2020

• Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients.

  CMAJ, 2010

• A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase.

  BioMed Research International, 2020

• Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy.

  Journal of Cosmetic Dermatology, 2024

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides.

  Medicina Cutanea Ibero-latino-americana, 1986

• Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models.

  Metabolites, 2021

• Topical application of 10% evening primrose oil (EPO) and Lioxasol creams resulted in increased cell proliferative activity in the skin of female pigs compared to untreated skin, with EPO producing a more pronounced increase in basal layer labelling index and Lioxasol causing a more immediate increase in papillary dermis labelled cells.

  Cell Proliferation, 1997

• A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation.

  Journal of Cosmetic Dermatology, 2019

• Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil.

  Nanomaterials, 2022

• A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline.

  Journal of Cosmetic Dermatology, 2010

Why other toners fit mature skin better

• Topical Tasmannia lanceolata extract reduced skin roughness, increased firmness, dermal density, and thickness of stabilized stretch marks compared to placebo in 29 women over 8 weeks, alongside increased pro-collagen I, elastin, and TGF-beta concentrations in ex vivo human skin explants.

  Journal of Cosmetic Dermatology, 2021

• Topical application of a cream containing 4% Saussurea lappa extract significantly improved skin roughness, scaliness, wrinkles, and smoothness in healthy human subjects after 30, 60, and 90 days of continuous use compared to baseline.

  Pakistan Journal of Pharmaceutical Sciences, 2017

• A cosmetic cream containing Harungana madagascariensis plant extract induces similar anti-aging effects to a retinol-containing cream on 46 human subjects, improving wrinkles, ptosis, color homogeneity, smoothness, plumpness, firmness, and elasticity.

  Clinical, Cosmetic and Investigational Dermatology, 2023

Ingredients

Water, Methylpropanediol, Tromethamine, Lactic Acid, Ethanol, 1,2-Hexanediol, Butylene Glycol, Glycerin, Oenothera Biennis Flower Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Pueraria Lobata Root Extract, Salicylic Acid, Vitis Vinifera Fruit Extract Grape Fruit Extract, Citrus Aurantifolia Fruit Extract, Lemon Fruit Extract, Pyrus Malus Fruit Extract, Citrus Aurantium Dulcis Fruit Extract, Centella Asiatica Extract, Willow Bark Extract, Origanum Vulgare Leaf Extract, Chamaecyparis Obtusa Leaf Extract, Lactobacillus Soybean Extract Ferment, Cinnamomum Cassia Bark Extract, Scutellaria Baicalensis Root Extract, Portulaca Oleracea Extract, Sodium Hyaluronate, Betaine Salicylate, Lemon Peel Oil, Bergamot Oil Fruit, Eucalyptus Globulus Oil Leaf, Rosmarinus Officinalis Oil Leaf Rosemary Oil Leaf, Lavandula Angustifolia Oil Lavender Oil, Citrus Aurantium Dulcis Peel Oil, Grapefruit Peel Oil, Betaine, Allantoin, Trehalose, Glycereth-26, Polyglyceryl-10 Laurate, Polyglyceryl-10 Myristate, Ammonium Acryloyldimethyltaurate Vp Copolymer, Disodium Edta, Ethyl Hexanediol, Ethylhexylglycerin, Citral, Isoeugenol, Cinnamal, Geraniol, Linalool, Citronellol, Limonene

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.