Medicube Triple Collagen Serum for oily acne-prone skin
Triple Collagen Complex
Sodium Hyaluronate
Niacinamide
AdenosineAverage
- AverageOily Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for oily acne-prone skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate hydration and firming benefits for your oily skin, as glycerin and niacinamide help regulate oil production and retain moisture, but the multiple collagen and hyaluronic acid derivatives are not directly targeted at your acne, blemishes, and breakouts.
- While the formula is generally safe and free from harsh irritants, it lacks sufficient mattifying or oil-controlling agents to fully address your concerns about oiliness or shiny skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.
How to apply
- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
People Say
★4.8Overall rating based on 200+ reviewsUsers frequently report this serum provides deep hydration, leading to a plumped, radiant complexion often described as 'glass skin'. It is well-loved for its smooth, non-greasy texture and effectiveness in diminishing fine lines, making it a great base for makeup. Some users find the fragrance to be strong and occasionally encounter issues with the packaging.
Highlights
Deep hydration Mostly Mentioned
- “Keeps skin hydrated even in depths of winter”
- “Skin feels nice and smooth”
- “Provides deep hydration.”
Glow and radiance Often Mentioned
- “Gives me glass skin”
- “Leaves a radiant glow”
- “Skin looks healthy and glowy.”
Good texture Sometimes Noted
- “Absorbs well without feeling sticky”
- “Silky texture”
- “Thick consistency but easy to apply.”
Plumping and anti-aging Sometimes Noted
- “Skin looks plumper”
- “Fine lines are diminished”
- “Improves skin elasticity.”
Packaging issues Sometimes Noted
- “Challenging to remove the cap”
- “Often taking the pump along with it”
- “Struggled to close it properly.”
Strong fragrance Sometimes Noted
- “Smells just a little bit cheap”
- “Contains fragrance”
- “Scent is a bit much.”
Makeup compatibility Rarely Noted
- “Layers beautifully under makeup”
- “Prevents makeup from looking cakey”
- “Perfect base for makeup.”
Skin sensitivity Rarely Noted
- “Caused small red bumps”
- “Feel a bit tingly”
- “Broke me out.”
Slightly sticky Rarely Noted
- “A bit sticky”
- “Can be a bit heavy”
- “Leaves a slight tack/film.”
Small quantity Rarely Noted
- “Amount is less than expected”
- “Use it up rather quickly”
- “Small bottle.”
Sources: lovi.care, iherb.com, yesstyle.com, olivekollection.com, beautybay.com, hikoco.co.nz, and more
Questions and answers
How well does Medicube Triple Collagen Serum work for oily acne-prone skin?
Medicube Triple Collagen Serum works moderately well for your oily acne-prone skin, offering moisture and firmness while helping manage oil, but it does not directly target your breakouts. Treatments that fit this skin better need ingredients like niacinamide, Vitamin C, and propolis to actively control oil and clear blemishes without causing breakouts.
Clinical, Cosmetic and Investigational Dermatology, 2017Scientific Reports, 2024
Which ingredients make this serum a good fit for oily acne-prone skin?
Glycerin and niacinamide make this serum a moderate fit for oily acne-prone skin by helping regulate oil production and retain moisture. A treatment for this skin needs ingredients like niacinamide, propolis, or Vitamin C, along with strong oil-controlling agents and soothing extracts to address blemishes and excess shine.
Clinical, Cosmetic and Investigational Dermatology, 2017Scientific Reports, 2024
What does Triple Collagen do for oily acne-prone skin?
Triple Collagen is not a good fit for oily acne-prone skin because heavy, rich ingredients of this type can clog pores and worsen breakouts. Oily acne-prone skin needs lightweight, oil-free hydration and ingredients like niacinamide that help calm redness and control excess shine without weighing the skin down.
What does Hyaluronic Acid do for oily acne-prone skin?
Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
The Journal of Investigative Dermatology, 2017Journal of Cosmetic Dermatology, 2022
Where does this serum go in a skincare routine for oily acne-prone skin?
This treatment goes in the evening routine after cleansing and toning, and before moisturizing. A product of this type needs blemish-clearing ingredients and oil-controlling agents to truly fit oily acne-prone skin.
Can I use this serum with retinol, and in what order?
Yes, you can use this serum with retinol by applying it after your retinol treatment to help keep your skin comfortable and hydrated. The formula has a safe and gentle profile that is unlikely to cause irritation when combined with active ingredients.
How often should I use this serum?
You can use this treatment in your evening routine for simplicity and extra safety around sun exposure. Oily acne-prone skin needs a product of this type that also includes strong oil-controlling and acne-fighting ingredients.
Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?
This serum is unlikely to cause purging or irritate your oily acne-prone skin, as it is free from harsh ingredients and contains soothing components. However, because it lacks strong oil-controlling agents and focuses mostly on hydration and firmness, an oily skin type typically needs ingredients like salicylic acid, zinc, or clay to properly manage breakouts and shine.
Is this serum fragrance-free and alcohol-free?
It contains fragrance (linalool and limonene) and drying alcohol (alcohol denat).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.
Journal of Pharmacy & Pharmaceutical Sciences, 2015Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.
Antioxidants, 2021Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021
Why other serums fit oily acne-prone skin better
A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.
Clinical Pharmacology, 2018Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 1,2-Hexanediol, Trehalose, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Atelocollagen, Desamido Collagen, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Cyclopentasiloxane, Hydroxypropyltrimonium Hyaluronate, Cyclohexasiloxane, Dimethicone, Benzyl Benzoate, Linalool, Limonene
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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