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Theramid Copper Peptide for acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Theramid Copper Peptide

Average

  • HighCombination Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for acne-prone skin; other serums fit it better.

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate benefits for combination skin, as copper tripeptide-1 and bifida lysate ferment support barrier repair and collagen stimulation, but lacks targeted ingredients for your acne, blemishes, and breakouts.
  • The presence of acetyl hexapeptide-1 and other peptides provides excellent skin repair and anti-aging benefits, though these are secondary to your primary concern of managing acne.
  • The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Use your serum as part of your PM routine and start 3x/week before working up to daily use.
  • Apply this treatment after cleansing and toner, and before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • Apply the product on clean, dry skin to help manage your breakouts safely.
  • Avoid the eye area and do a patch test before your first use.

People Say

★4.4Overall rating based on 100+ reviews

A lightweight, fast-absorbing texture is frequently praised, and a moderate number of users report a boost in skin radiance. Some users find the high silicone content problematic for layering and note that copper peptides require careful routine planning to avoid conflicts with other active ingredients.

Highlights

  • Improves firmness Often Mentioned
    • “my skin feels incredibly fed and plump”
    • “improving skin elasticity and firmness”
    • “it felt bouncier and more lifted”
    • “helps to improve signs of aging... firm, smooth, radiant, and younger-looking skin”
  • Lightweight, fast-absorbing Often Mentioned
    • “the texture is a sophisticated, lightweight gel that absorbs almost instantly without leaving a sticky residue”
    • “absorbs quickly, and doesn't leave any stickiness, which is a huge plus for those of us who prefer to layer products”
    • “it feels better on my skin... soaks in much better”
    • “light, gel-like consistency absorbs quickly without leaving a tacky residue”
  • Boosts radiance Sometimes Noted
    • “instantly gives the skin a radiant glow and freshness”
    • “my skin has gotten a lot brighter and a lot better”
    • “helps my complexion look lively”
    • “promote a more youthful glow”
  • Gentle, non-irritating Sometimes Noted
    • “incredibly gentle... I experienced zero redness or irritation”
    • “I experienced no redness or dryness, which is often a concern when introducing strong active ingredients”
    • “perfect for beginners, sensitive skin”
  • Hard to combine Sometimes Noted
    • “copper peptides are high maintenance... you really don't want to use it in with anything that has a low pH”
    • “I wouldn't recommend using it together with Niactilen”
    • “Do not use with other acids and retinol products”
  • High silicone content Rarely Noted
    • “I don't like the fact that is has so much silicone in it”
    • “makes it very difficult to rub on the skin, because it 'sticks' to first place you put it and doesn't blend well”
    • “This broke me out on my face”
  • No visible results Rarely Noted
    • “Nearly 2 months in, no result”
    • “No Effect”
    • “I have it, I can't say how effective it is”

Sources: lovi.care, peptides133.com, peptides136.com, peptides138.com, youtube.com, lyko.com, and more

Questions and answers

How well does Theramid Copper Peptide Serum work for acne-prone skin?

Theramid Copper Peptide works moderately well for acne-prone skin because its ingredients support barrier repair and collagen, though it lacks targeted acne-fighting ingredients. For a better fit, acne-prone skin needs products containing ingredients like niacinamide, propolis, and zinc PCA to manage breakouts while maintaining hydration.

Skin Research and Technology, 2026Journal of Cosmetic Dermatology, 2023

Which ingredients make this serum a good fit for acne-prone skin?

This serum works for acne-prone skin because copper tripeptide-1 and bifida lysate ferment help repair the skin barrier and calm redness. However, acne-prone skin needs a treatment with ingredients like niacinamide, zinc PCA, and propolis to directly target blemishes and control oil.

Skin Research and Technology, 2026Journal of Cosmetic Dermatology, 2023

What does Copper Tripeptide-1 do for acne-prone skin?

Copper Tripeptide-1 helps calm acne-prone skin by reducing inflammation and supporting overall skin repair. Because this is a weaker match for your skin, an ideal product of this type needs soothing ingredients and gentle hydrators to calm irritation without clogging pores.

Skin Research and Technology, 2026International Journal of Molecular Sciences, 2018

What does Acetyl Tetrapeptide-2 do for acne-prone skin?

Acetyl Tetrapeptide-2 helps improve the firmness and overall structural properties of acne-prone skin. This ingredient is unlikely to cause irritation and may support skin resilience, though acne-prone skin typically benefits most from additional soothing and blemish-clearing ingredients.

International Journal of Peptide Research and Therapeutics, 2018

Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in your evening routine after cleansing and toning, and before moisturizing. Acne-prone skin needs a product of this type that also includes targeted ingredients to clear blemishes and breakouts.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying your retinol first and following with this treatment once it absorbs. This product is unlikely to cause irritation on your skin since it lacks harsh ingredients, but acne-prone skin needs products with targeted blemish-fighting ingredients to see clear results.

How often should I use it?

Use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. Acne-prone skin works best with products that include targeted blemish-clearing ingredients and soothing agents to help manage breakouts.

Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts or purging for acne-prone skin, as it contains no harsh ingredients that trigger irritation. However, because it lacks targeted ingredients for blemishes, acne-prone skin needs a product with blemish-fighting agents and lightweight, non-clogging hydrators for the best fit.

Journal of Cosmetic Dermatology, 2023Skin Research and Technology, 2026

Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.

    Skin Research and Technology, 2026

  • Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.

    Journal of Cosmetic Dermatology, 2023

  • Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.

    Archives of Facial Plastic Surgery, 2006

  • A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.

    Cureus, 2024

  • Copper applied transdermally as a tripeptide on human skin ex vivo permeated the tissue and was retained in amounts potentially effective for treating inflammatory diseases.

    Inflammation Research, 2010

  • Treatment of immortalized human keratinocytes with Acetyl Tetrapeptide-2 increased cell stiffness across its concentration range, while Acetyl Hexapeptide-50 increased stiffness at 0.05 µg/ml but decreased it at 0.5 and 5 µg/ml compared to untreated controls.

    International Journal of Peptide Research and Therapeutics, 2018

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

Why other serums fit acne-prone skin better

Ingredients

Water, Propanediol, Cyclopentasiloxane, Dimethicone, Betaine, Copper Tripeptide-1, Bifida Lysate Ferment, Cyclohexasiloxane, Glycerin, Sodium Chloride, Polyglyceryl-4 Isostearate, Sodium Hyaluronate, Acetyl Tetrapeptide-2, Trifluoroacetyl Tripeptide-2, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-11, Sh-Polypeptide-9, Acetyl Hexapeptide-1, Bacillus Folic Acid Extract Ferment Filtrate, Cetyl Peg Ppg-10 1 Dimethicone, Hexyl Laurate, Peg Ppg-18 18 Dimethicone, Lecithin, Acetyl Glutamine, Caprylyl Glycol, Butylene Glycol, Dextran, Disodium Edta, Acetic Acid, Lactic Acid, 1,2-Hexanediol, Sodium Benzoate, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play