COSRX Centella Blemish Cream for acne-prone skin

How to apply

Questions and answers

What the research says

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris.

  The Journal of Clinical and Aesthetic Dermatology, 2020

• Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles selectively inhibited C. acnes, outperformed erythromycin in preclinical acne models, and safely reduced acne lesions and redness in a clinical trial.

  Journal of Controlled Release, 2025

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Topical herbal treatments including lemon balm, olive leaf extract, propolis, and sage-rhubarb cream reduce pain, swelling, lesion size, and healing time in patients with herpes labialis compared with placebo or acyclovir.

  Journal of Integrative and Complementary Medicine, 2025

• Topical oleuropein formulations reduced erythema, transepidermal water loss, and blood flow by approximately 22%, 35%, and 30% in healthy volunteers with UVB-induced erythema.

  International Journal of Cosmetic Science, 2008

• An oil-in-serum formulation containing olive extract standardized in hydroxytyrosol improved skin barrier function and significantly reduced hyperpigmentation in participants with post-inflammatory hyperpigmentation after 45 days of application.

  AAPS PharmSciTech, 2026

Ingredients

Centella Asiatica Leaf Water, Butylene Glycol, Glycerin, Helianthus Annuus Seed Oil Sunflower Seed Oil, Zinc Oxide, Dimethicone, Betaine, 1,2-Hexanediol, Viola Tricolor Extract, Palm Oil, Palm Kernel Oil, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Centella Asiatica Extract, Zinc Pca, Xanthan Gum, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Melaleuca Alternifolia Tree Oil Leaf, Scutellaria Baicalensis Root Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.