Protease and palmitoyl pentapeptide-4
Keep them apart
Use them at different times of day, applying the protease first and the peptide later, because they cancel each other out. Protease breaks down the peptide, making it completely useless on your skin. You can space them out by using one in the morning and the other at night.
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Questions and answers
Can you use protease and palmitoyl pentapeptide-4 together?
Keep protease and palmitoyl pentapeptide-4 apart because proteolytic enzymes may degrade peptide bonds and render the active peptide inactive. Avoid combining them in the same routine.
Which goes first, protease or palmitoyl pentapeptide-4?
Keep protease and palmitoyl pentapeptide-4 apart because enzymes can degrade peptide bonds and render the peptides inactive. You should avoid combining proteolytic enzymes with peptides in the same routine.
Are protease and palmitoyl pentapeptide-4 good for sensitive skin?
No, you should keep protease and palmitoyl pentapeptide-4 apart because enzymes can degrade peptide bonds and render the peptides inactive. It is best to avoid combining enzymatic ingredients with peptide-containing products in the same routine.
Research on protease and palmitoyl pentapeptide-4
Behind this pairing advice
Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sof铆a Perea P茅rez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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