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Vitamin A and palmitoyl pentapeptide-4

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Vitamin A and palmitoyl pentapeptide-4: keep them apart

Keep them apart

Use them at different times of day by applying vitamin A at night and palmitoyl pentapeptide-4 in the morning to avoid extra skin irritation. Using both strong ingredients at the same time can cause your skin to become red, sensitive, and irritated. You can solve this by switching to a gentler strength or waiting longer between applying the two products.

Vitamin A products

Palmitoyl pentapeptide-4 products

Questions and answers

Can you use vitamin A and palmitoyl pentapeptide-4 together?

Keep vitamin A and palmitoyl pentapeptide-4 apart in your routine because combining them may increase irritation, so you should alternate usage by applying a retinoid in the PM and peptides in the AM.

Which goes first, vitamin A or palmitoyl pentapeptide-4?

Keep vitamin A and palmitoyl pentapeptide-4 apart because combined stimulation may increase irritation, so use them at different times such as applying vitamin A in the evening and peptides in the morning.

Are vitamin A and palmitoyl pentapeptide-4 good for sensitive skin?

Keep vitamin A and palmitoyl pentapeptide-4 apart because combined stimulation may increase irritation in sensitive skin. Alternate your usage by applying the retinoid in the PM and peptides in the AM.

Research on vitamin A and palmitoyl pentapeptide-4

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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