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Protease and palmitoyl pentapeptide-4

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Protease and palmitoyl pentapeptide-4: keep them apart

Keep them apart

Use them at different times of day, applying the protease first and the peptide later, because they cancel each other out. Protease breaks down the peptide, making it completely useless on your skin. You can space them out by using one in the morning and the other at night.

Protease products

Palmitoyl pentapeptide-4 products

Questions and answers

Can you use protease and palmitoyl pentapeptide-4 together?

Keep protease and palmitoyl pentapeptide-4 apart because proteolytic enzymes may degrade peptide bonds and render the active peptide inactive. Avoid combining them in the same routine.

Which goes first, protease or palmitoyl pentapeptide-4?

Keep protease and palmitoyl pentapeptide-4 apart because enzymes can degrade peptide bonds and render the peptides inactive. You should avoid combining proteolytic enzymes with peptides in the same routine.

Are protease and palmitoyl pentapeptide-4 good for sensitive skin?

No, you should keep protease and palmitoyl pentapeptide-4 apart because enzymes can degrade peptide bonds and render the peptides inactive. It is best to avoid combining enzymatic ingredients with peptide-containing products in the same routine.

Research on protease and palmitoyl pentapeptide-4

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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