Perricone MD Vitamin C Ester CCC+ Ferulic Brightening Under-Eye Cream for mature skin

Questions and answers

What the research says

• A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo.

  Polymers, 2023

• Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.

  International Journal of Biological Macromolecules, 2026

• Topical formulations containing ascorbyl tetraisopalmitate, coenzyme Q10, green tea polyphenols, and resveratrol reduced the release of inflammatory cytokines and attenuated inflammatory signs compared to untreated skin and vehicle in 25 Japanese volunteers exposed to sodium dodecyl sulfate.

  European Journal of Pharmaceutics and Biopharmaceutics, 2017

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening.

  Dermatologic Therapy, 2022

• Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo.

  The Journal of Dermatological Treatment, 2025

• Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control.

  Journal of Cosmetic Dermatology, 2008

• Topical cream containing saffron extract and avocado oil improved wrinkle grading, reduced nasolabial fold area and volume, and increased skin elasticity in twenty healthy volunteers over 12 weeks without allergic reactions.

  Journal of Cosmetic Dermatology, 2020

• Topical treatment with SSFAO 50% or avocado oil increased wound contraction, reepithelialization, collagen density, and tensile strength while showing anti-inflammatory activity compared to petroleum jelly in rats.

  Evidence-based Complementary and Alternative Medicine, 2013

• A single use of an alpha-tocopherol-enriched rinse-off product strongly increases alpha-tocopherol levels in skin barrier lipids maintained for at least 24 hours and significantly inhibits squalene photooxidation in human volunteers compared to a control product.

  Skin Pharmacology and Physiology, 2005

• The investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams showed no skin irritation and provided increased skin hydration and reduced transepidermal water loss in 76 healthy volunteers.

  Vojnosanitetski Pregled, 2016

• Topical treatment with a mixed RetinSphere - vitamin E formulation significantly decreased lipid peroxidation levels and oxidized squalene percentage, reduced interleukin-1α concentration in lesional areas, and led to clinical improvement in 18 patients with mild comedonal acne.

  Journal of the European Academy of Dermatology and Venereology, 2014

Ingredients

Water, 3-O-Ethyl Ascorbic Acid, Caprylic Capric Triglyceride, Glycerin, Dimethicone, Tetrahexyldecyl Ascorbate, Glyceryl Stearate, Cetearyl Alcohol, Sodium Acrylates Copolymer, Butylene Glycol, Persea Gratissima Oil Avocado Oil, Sodium Ascorbyl Phosphate, Sodium Tocopheryl Phosphate, Tocopheryl Acetate, Pentylene Glycol, Phenoxyethanol, Lecithin, Sodium Stearoyl Glutamate, Hydroxyphenoxy Propionic Acid, Escin, Ferulic Acid, Sodium Hydroxide, Sodium Metabisulfite, Ethylhexylglycerin, Panthenol, Tetrasodium Glutamate Diacetate, Hydroxyphenyl Propamidobenzoic Acid, Citric Acid, Astaxanthin Extract, Tocopherol, Phytic Acid, Sodium Benzoate, Ascorbyl Palmitate, Potassium Sorbate, Acetyl Tetrapeptide-5, Beta-Sitosterol, Squalene

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.