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Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for dry sensitive skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer

High

  • SuperiorDry Skin Fit
  • HighEffectiveness
  • HighSafety

A great choice for dry sensitive skin; a few moisturizers fit it even better.

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Excellent suitability for your dry skin is provided by glycerin, linum usitatissimum seed oil, and macadamia ternifolia seed oil, which offer deep moisturization and nourishment through humectant and emollient actions.
  • The presence of S-palmitoylglutathione and ribose further enhances skin elasticity and provides general skincare benefits, supporting your dry or flaky skin.
  • The product is safe for your dry and sensitive skin, as it contains no harsh or prohibited ingredients that could cause irritation.

How to apply

  • Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
  • Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
  • Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
  • Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
  • Do a patch test before your first use. Avoid the eye area to prevent any irritation.

People Say

★4.5Overall rating based on 500+ reviews

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

Highlights

  • Deeply hydrating Mostly Mentioned
    • “Keeps skin hydrated all day.”
    • “Great for dry patches.”
    • “Feels very moisturizing.”
  • Fast absorbing Often Mentioned
    • “Absorbs fast, not greasy.”
    • “No residue feel afterwards.”
    • “Absorbs quickly without stickiness.”
  • Pleasant texture Often Mentioned
    • “Light, velvety texture.”
    • “Not too heavy, not too light.”
    • “Creamy, not greasy.”
  • Expensive price Often Mentioned
    • “On the steep side.”
    • “More expensive side.”
    • “Price is quite high.”
  • Improves radiance Sometimes Noted
    • “Produces a radiant glow.”
    • “Skin looks healthier.”
    • “Imparts a beautiful radiance.”
  • Limited wrinkle results Sometimes Noted
    • “Haven't noticed much difference.”
    • “Not as good as advertised.”
    • “Deep lines remain.”
  • Strong fragrance Rarely Noted
    • “Fragrance too strong.”
    • “Concerned about fragrance.”
    • “Experienced minor irritation.”

Sources: lovi.care, perriconemd.com, mecca.com.au, macys.com, nordstrom.com, ipsy.com, and more

Questions and answers

What makes Perricone MD Rejuvenating Moisturizer a great fit for dry sensitive skin?

This moisturizer is a great fit because glycerin and plant seed oils provide deep moisture and nourishment, while soothing ingredients help improve skin feel without causing irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for dry sensitive skin?

Glycerin, linseed oil, and macadamia oil make this cream a great fit by deeply quenching and nourishing dry skin. S-palmitoylglutathione and ribose further improve skin smoothness and support flaky areas safely without causing irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

What does Acyl-Glutathione do for dry sensitive skin?

Acyl-Glutathione helps protect dry sensitive skin against environmental and oxidative stress while improving overall moisture and smoothness. It is unlikely to cause irritation and supports a calm, healthy look.

Journal of the European Academy of Dermatology and Venereology, 2024Clinical, Cosmetic and Investigational Dermatology, 2014

What does Vitamin C do for dry sensitive skin?

Vitamin C helps make dry, sensitive skin feel softer and calmer while improving firmness and reducing redness. Studies show that gentle forms of vitamin C can improve skin hydration and elasticity safely without causing irritation.

Antioxidants, 2024Journal of Cosmetic Dermatology, 2019

Where does this cream go in a skincare routine for dry sensitive skin?

This moisturizing treatment goes in the evening routine after your toner and before your moisturizer. It is a great fit for dry sensitive skin because it provides deep moisturization and nourishment while containing no harsh ingredients that could cause irritation.

The Journal of Dermatological Treatment, 2022

Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the retinol first, letting it absorb, and then following with this moisturizer to help keep your dry skin calm and hydrated. This approach is unlikely to cause irritation because the product contains no harsh ingredients and features nourishing oils that support your skin barrier.

Cutis, 2006

How often should I use this cream?

You can use this moisturizing treatment in your evening routine, applying it once a day to support your dry and sensitive skin. Daily application helps improve skin hydration, smoothness, and overall barrier comfort over time.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for dry sensitive skin?

This cream is unlikely to clog pores or cause breakouts for dry sensitive skin because it is free of harsh or prohibited ingredients that typically trigger irritation. It helps keep skin soft and comfortable without causing congestion.

Can I use this cream around the eyes or on my body?

You can safely use this moisturizing treatment around the eyes and on the body because it contains gentle ingredients that suit sensitive skin. It is unlikely to cause irritation and helps improve skin texture and moisture in delicate areas.

Clinical, Cosmetic and Investigational Dermatology, 2017

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

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