O Hui The First Geniture Essence for skin with dark spots

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Questions and answers

What the research says

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone.

  The New England Journal of Medicine, 1989

• Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba.

  Lasers in Surgery and Medicine, 2020

• Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars.

  The Journal of Clinical and Aesthetic Dermatology, 2022

• Partially purified paeoniflorin protected human keratinocytes and mouse skin from UV-induced DNA damage and reduced facial wrinkles in human volunteers.

  Journal of Cosmetic Science, 2006

• Paeonia suffruticosa callus extract downregulated inflammatory factors, alleviated DNA damage, and increased total collagen content in in vitro and in vivo evaluations.

  International Journal of Cosmetic Science, 2025

• Topical application of Paeonia lactiflora root extract and paeoniflorin significantly decreases melanin content by 23% to 30% in reconstructed pigmented human epidermis compared to vehicle control.

  International Journal of Cosmetic Science, 2016

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

Ingredients

Water, Glycerin, Dipropylene Glycol, Neopentyl Glycol Dicaprate, Cyclopentasiloxane, Squalane, 1,2-Hexanediol, Panthenol, Polyglyceryl-3 Methylglucose Distearate, Glyceryl Stearate, Butyrospermum Parkii Butter Shea Butter, Ceteareth-6 Olivate, Dipentaerythrityl Hexa C5-9 Acid Esters, Peg-100 Stearate, Methyl Glucose Sesquistearate, Cetearyl Alcohol, Stearic Acid, Perfluorononylethyl Stearyl Dimethicone, Dimethicone, Butylene Glycol, Carbomer, Tromethamine, Hydrogenated Lecithin, Xanthan Gum, Caprylic Capric Triglyceride, Mica, Titanium Dioxide Ci 77891, Hydroxyethylcellulose, Sodium Hyaluronate, Arachidyl Alcohol, Trisodium Edta, Paeonia Suffruticosa Branch Leaf Extract Flower, Behenyl Alcohol, Phytosteryl Isostearyl Cetyl Stearyl Behenyl Dimer Dilinoleate, Peg-8 Caprylic Capric Glycerides, Iron Oxides Ci 77491, Arachidyl Glucoside, Polysorbate 20, Ceramide Np, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Cholesterol, Glycoproteins, Paeonol, Oligopeptide-1, Oligopeptide-2, Oligopeptide-3, Oligopeptide-6, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Oligopeptide-4

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.