Medicube Zero Exosome Shot for dry sensitive skin
Lacto Exosome
Niacinamide
Betaine Salicylate
Adenosine
Hydrolyzed Sponge
Average
- AverageDry Skin Fit
- AverageEffectiveness
- HighSafety
Works for dry sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your dry skin, as glycerin and panthenol provide humectant action, while niacinamide and gluconolactone help even skin tone and smooth texture.
- While the formula offers general skincare benefits, it lacks specialized ingredients like ceramides or hyaluronic acid in concentrations that would optimally support your dry or flaky skin and sensitivity.
- The product is safe for your dry and sensitive skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
People Say
★4.7Overall rating based on 100+ reviewsUsers describe this ampoule as a potent texturizing treatment that delivers a glass skin finish by minimizing pores and smoothing roughness. While highly effective for many in tightening pores and boosting radiance, the sensation is polarizing, often described as a prickly or tingling feeling that can be intense for sensitive skin.
Highlights
Smoother texture Mostly Mentioned
- “bumpy texture is finally smooth”
- “skin feels silky smooth”
- “makeup glides on easier”
- “glass-like skin”
Prickly sensation Mostly Mentioned
- “feels like fiberglass”
- “stinging all over”
- “uncomfortable prickly feel”
- “like tiny needles poking”
Pore minimization Often Mentioned
- “black dots on my nose have all but disappeared”
- “pores are the smallest they've ever been”
- “immediate and certain pore tightening”
- “pores looked teeny tiny”
Radiance and glow Often Mentioned
- “radiates with a healthy glow”
- “skin looked noticeably brighter”
- “complexion looks clearer”
Enhanced absorption Sometimes Noted
- “makes all my serums work better”
- “acts as a pathway to enhance absorption”
- “products sink in deeper”
Skin irritation Sometimes Noted
- “led to redness and breakouts”
- “left me feeling raw”
- “too intense for sensitive skin”
- “caused irritation”
Lack of results Rarely Noted
- “skin looking the exact same”
- “didn't really work for me”
- “not sure what exactly this is doing”
Unpleasant texture Rarely Noted
- “sticky after-feel”
- “heavy on sensitive skin”
- “feels a bit tacky”
Sources: lovi.care, stylekorean.com, skinsort.com, medicube.us, instyle.com, newbeauty.com, and more
Questions and answers
How well does the Zero Exosome Shot work for dry sensitive skin?
The MEDICUBE Zero Exosome Shot works reasonably well for dry sensitive skin, as glycerin and panthenol pull in moisture while niacinamide helps smooth texture. It is safe for sensitive skin, but a product of this type needs specialized ingredients like ceramides or hyaluronic acid to properly target dryness and flakiness.
The British Journal of Dermatology, 2002American Journal of Clinical Dermatology, 2002
Which ingredients make this serum a good fit for dry sensitive skin?
Glycerin and panthenol make this serum a good fit because they draw moisture into dry skin and help calm irritation. Niacinamide and gluconolactone also help even out skin tone and smooth texture safely.
American Journal of Clinical Dermatology, 2002The Journal of Dermatological Treatment, 2017
What does Lacto Exosome do for dry sensitive skin?
Lacto Exosome helps strengthen dry sensitive skin by supporting the skin barrier so it holds onto moisture better. It does this by boosting key proteins that keep the skin smooth and resilient.
What does Niacinamide do for dry sensitive skin?
Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Journal of Cosmetic Dermatology, 2004International Journal of Pharmaceutics, 2013
Where does this serum go in a skincare routine for dry sensitive skin?
This treatment goes in your evening routine after your soothing toner and before your moisturizer. A dry skin routine needs rich hydrators like ceramides or hyaluronic acid to properly support and comfort dry or flaky skin.
Can I use this serum with retinol, and in what order?
This treatment is safe for your dry and sensitive skin, but since it lacks strong moisture-locking ingredients, this skin type needs added ceramides or hyaluronic acid to stay comfortable alongside strong products like retinol.
How often should I use this serum?
Start by using this treatment once a week in your evening routine, and if your skin tolerates it well without irritation, you may carefully use it more often. This product works for your dry sensitive skin, but to truly support dryness and flakiness, a product of this type needs rich moisturizing ingredients like ceramides or hyaluronic acid.
Can this serum clog pores, cause breakouts or purging for dry sensitive skin?
This treatment is unlikely to clog pores or cause breakouts for your dry sensitive skin, as its safe formula lacks harsh ingredients. However, to truly comfort dry or flaky skin, a product of this type needs rich moisture-locking ingredients and barrier-repairing ceramides or hyaluronic acid.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017Lactobacillus-derived exosome therapy combined with microneedling reduced acne severity, post-inflammatory hyperpigmentation, and atrophic scarring in three patients, with high satisfaction and minimal adverse effects.
The Journal of Craniofacial Surgery, 2025Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021A nano-encapsulated spicule system delivering Wharton's Jelly MSC secretome enhanced transdermal penetration, promoted cell proliferation and collagen synthesis in vitro, and reduced wrinkles and pigmentation in clinical evaluation.
International Journal of Molecular Sciences, 2025Deer antler velvet extract formulated in sponge spicule micro-blend cream applied to healthy humans for 14 days enhanced macromolecule skin permeation by 1.94-fold, decreased melanin content and erythema, and increased skin elasticity and hydration without causing irritation.
Biological & Pharmaceutical Bulletin, 2019Marine sponge spicules enhanced the skin delivery of human umbilical cord-derived mesenchymal stem cell exosomes by a factor of 5.87 and combined with them produced significant anti-photoaging effects in mice compared to exosomes alone.
International Journal of Nanomedicine, 2020
Why other serums fit dry sensitive skin better
Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks.
Journal of Cosmetic Dermatology, 2022Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.
European Journal of Pharmaceutics and Biopharmaceutics, 2016In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle.
Skin Pharmacology and Physiology, 2026
Ingredients
Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, Hydrolyzed Sponge, C12-14 Alketh-12, Hydrogenated Polydecene, Ethylhexylglycerin, Adenosine, Caprylyl Capryl Glucoside, Disodium Edta, Panthenol, Calcium Silicate, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Ulmus Davidiana Root Extract, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.