APLB Glutathione Niacinamide Sunscreen for skin with dark spots

How to apply

Questions and answers

What the research says

• Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.

  Journal of the European Academy of Dermatology and Venereology, 2024

• Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy.

  Journal of Cosmetic Dermatology, 2021

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

• Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.

  Drug Delivery, 2017

• Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.

  The Journal of Clinical and Aesthetic Dermatology, 2025

• RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation.

  American Journal of Surgery, 2005

• Combining high-intensity focused ultrasound with a topical agent containing glutathione and hyaluronic acid significantly improves skin quality, fine wrinkles, hyperpigmentation, hydration, and brightness in female volunteers compared to the topical agent alone.

  The Journal of Dermatological Treatment, 2024

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

Ingredients

Water, Ethylhexyl Methoxycinnamate, Butylene Glycol, Ethylhexyl Salicylate, Octocrylene, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Butyl Methoxydibenzoylmethane, Dipropylene Glycol, Squalane, C14-22 Alcohols, 1,2-Hexanediol, Polyglyceryl-2 Stearate, Propanediol, Hydroxyacetophenone, Glyceryl Stearate, Stearyl Alcohol, C12-20 Alkyl Glucoside, Tromethamine, Carbomer, Melaleuca Alternifolia Tree Extract, Hippophae Rhamnoides Fruit Extract, Vitis Vinifera Fruit Extract Grape Fruit Extract, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Uncaria Sinensis Extract, Glycerin, Adenosine, Disodium Edta, Rice Bran Extract, Hydrogenated Phosphatidylcholine, Caprylic Capric Triglyceride, Sodium Hyaluronate, Glucose, Hydrolyzed Collagen, Sucrose Stearate, Glutathione, Cyclodextrin, Cetearyl Alcohol, Caprylyl Glycol, Beta-Glucan, Caprylhydroxamic Acid, Ethylhexylglycerin, Asiatic Acid, Asiaticoside, Madecassic Acid, Madecassoside, Tropolone, Potassium Hyaluronate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.