the SAEM Gem Miracle Black Pearl O2 Bubble Mask for skin with dark spots

How to apply

Questions and answers

What the research says

• Poly-gamma-glutamic acid derived from a novel Bacillus subtilis strain dose-dependently increased skin barrier markers, hyaluronic acid synthesis, and aquaporin 3 expression in keratinocytes, and elevated filaggrin, involucrin, CD44, and aquaporin 3 expression in a reconstructed skin model compared to the control.

  International Journal of Molecular Sciences, 2025

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Micro and nanosized pearl powders increased skin cell proliferation and migration, accelerated wound closure, enhanced biomechanical strength, improved collagen deposition, and promoted angiogenesis in rats, with nanoscale pearl powder showing the highest efficiency.

  Drug Development and Industrial Pharmacy, 2019

• Topical pearl extract gel inhibited UV-irritated skin wrinkles, laxity, thickness, and dryness, upregulated antioxidant enzyme activities, decreased MDA levels, and suppressed inflammatory factors in UV-irradiated mice compared to untreated controls, with high-dose PEG showing superior effects to Vitamin E.

  Chemistry & Biodiversity, 2022

• Seawater pearl powder treatment significantly improves UV-induced photoaging and restores skin tissue structure in mice by reducing MMP-1, enhancing collagen I, inhibiting the MAPK signaling pathway, and scavenging reactive oxygen species.

  Evidence-based Complementary and Alternative Medicine, 2021

• Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo.

  Wilderness & Environmental Medicine, 2016

• A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face.

  Giornale Italiano Di Dermatologia E Venereologia, 2015

• Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation.

  Molecules, 2020

• Adjuvant topical oxygen therapy significantly increased the rate of healed wounds compared to standard wound care in patients with chronic wounds.

  International Wound Journal, 2024

• Negative pressure wound therapy combined with topical oxygen therapy increased the healing rate, reduced time from debridement to skin grafting, shortened healing time, enhanced granulation coverage, and decreased bacterial positivity compared with negative pressure wound therapy alone in patients with chronic refractory wounds.

  Advances in Wound Care, 2026

• Topical wound oxygen therapy is evaluated for its efficacy and safety in treating chronic refractory wounds among 250 high-altitude residents compared to sham oxygen therapy.

  PloS One, 2025

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

Ingredients

Water, Glycerin, Cocamidopropyl Betaine, Acrylates Copolymer, Methyl Perfluorobutyl Ether, Methyl Perfluoroisobutyl Ether, Ammonium Laureth Sulfate, Polysorbate 20, Disodium Cocoamphodiacetate, Butylene Glycol, Peg-8, Phenoxyethanol, Potassium Hydroxide, Chlorphenesin, Ppg-26-Buteth-26, Peg-40 Hydrogenated Castor Oil, Laureth-3, Sodium Sulfate, Mica, Polyhydroxystearic Acid, Hexylene Glycol, Ethylhexyl Isononanoate, Tetrasodium Edta, Isononyl Isononanoate, Iron Oxides Ci 77491, Titanium Dioxide, Sodium Cocamidopropyl Pg-Dimonium Chloride Phosphate, Sodium Benzoate, Portulaca Oleracea Extract, Sucrose Dilaurate, Hydrolyzed Pearl, Pearl Powder, Alcohol, Carica Papaya Fruit Extract, Ci 17200, Ci 19140, Alchemilla Vulgaris Leaf Extract, Achillea Millefolium Extract, Potassium Cetyl Phosphate, Primula Veris Extract, Malva Sylvestris Extract, Melissa Officinalis Leaf Extract, Peppermint Leaf Extract, Veronica Officinalis Extract, Ci 42090, Pisum Sativum Extract, Potassium Sorbate, Polyglutamic Acid, Panthenol, Caprylyl Glycol, Sorbic Acid, Camellia Sinensis Leaf Extract, Escin, P-Anisic Acid, Soy Phthalate Protein, Ruscus Aculeatus Root Extract, Hibiscus Abelmoschus Seed Extract, Acmella Oleracea Extract, Ammonium Glycyrrhizate, Disodium Edta, Oxygen, Centella Asiatica Extract, Bacillus Soybean Extract Ferment, 1,2-Hexanediol, Sodium Hydroxide, Hydrolyzed Yeast Protein, Calendula Officinalis Flower Extract, Sodium Citrate, Willow Bark Extract, Acetyl Tetrapeptide-3, Fomes Officinalis Extract Mushroom Extract, Xanthan Gum, Ethylhexylglycerin, Dextran, Peg-5 Phytosterol, Ceteth-4, Cholesterol, Glycine Soja Soybean Sterols, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.