Sulwhasoo Timetreasure Renovating Cream for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use.

  Journal of Cosmetic Dermatology, 2022

• A xanthan gum and alginate-based bioadhesive film loaded with pycnogenol provides sustained drug release within 24 hours, achieves a safe maximum concentration of ~ 0.2 mg/mL for keratinocytes, and absorbs simulated wound fluid, demonstrating suitability for topical wound treatment.

  Pharmaceutics, 2021

• Topical treatment with Pinus brutia bark extract cream significantly accelerated incision wound healing in albino rats, demonstrating a 35% decrease in MDA and a 46.8% increase in SOD activity compared to the control group.

  Die Pharmazie, 2013

• Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

  Rejuvenation Research, 2015

• A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

  Journal of Ginseng Research, 2022

• A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

  Journal of Toxicology and Environmental Health. Part A, 2020

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism.

  BioFactors, 2008

• Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects.

  Colloids and Surfaces. B, Biointerfaces, 2023

• Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects.

  Antioxidants, 2021

• Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism.

  Evidence-based Complementary and Alternative Medicine, 2015

• Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo.

  Experimental Dermatology, 2015

• Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide.

  Advanced Science, 2025

Why other moisturizers fit skin with dark spots better

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

• Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.

  International Journal of Medical Sciences, 2021

Ingredients

Pinus Sylvestris Bark Extract, Water, Glycerin, Butylene Glycol, Cyclopentasiloxane, Dimethicone, Limnanthes Alba Seed Oil, Pentaerythrityl Tetraisostearate, Peg-10 Dimethicone, Trisiloxane, Pentaerythrityl Tetraethylhexanoate, Angelica Acutiloba Root Extract, Artemisia Vulgaris Extract, Cnidium Officinale Root Extract, Peg-30 Dipolyhydroxystearate, Diisostearyl Malate, Disteardimonium Hectorite, Panax Ginseng Root Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Ophiopogon Japonicus Root Extract, Paeonia Albiflora Root Extract, Nelumbo Nucifera Seed Extract, Polygonatum Officinale Root Extract Rhizome, Lilium Tigrinum Stem Extract Flower Leaf, Rehmannia Glutinosa Root Extract, Chrysanthemum Morifolium Flower Extract, Paeonia Suffruticosa Root Extract, Citrus Unshiu Peel Extract, Adenophora Stricta Root Extract, Lycium Chinense Root Extract, Coix Lacryma-Jobi Ma-Yuen Seed Extract, Angelica Tenuissima Root Extract, Honey, Prunus Mume Fruit Extract, Sesamum Indicum Seed Extract, Pinus Koraiensis Seed Extract, Chaenomeles Sinensis Fruit Extract, Rosa Multiflora Fruit Extract, Pinus Sylvestris Leaf Extract, Camellia Sinensis Leaf Extract, Sodium Hyaluronate, Beta-Glucan, Hydrolyzed Ginseng Saponins Enzyme Treated Red Ginseng Saponins, Oldenlandia Diffusa Extract, Perilla Ocymoides Seed Extract, Portulaca Oleracea Extract, Theobroma Cacao Extract, Dimethiconol, Magnesium Sulfate, Propanediol, Pantethine, Cetyl Peg Ppg-10 1 Dimethicone, Alcohol, Boron Nitride, Hexyldecyl Myristoyl Methylaminopropionate, Peg-30 Hydrogenated Castor Oil, Polyquaternium-51, Methoxy Peg-114 Polyepsilon Caprolactone, Dextrin, Tocopheryl Acetate, Ethylhexylglycerin, Caprylic Capric Triglyceride, Calcium Pantetheine Sulfonate, Ammonium Acryloyldimethyltaurate Vp Copolymer, Behenyl Alcohol, Sodium Ascorbyl Phosphate, Polyglyceryl-10 Pentastearate, Cetearyl Alcohol, Sodium Stearoyl Lactylate, Cetearyl Glucoside, Cyclomethicone, Salicylic Acid, Ubiquinone, Silica Silylate, Hydrogenated Lecithin, Hydrolyzed Rice Protein, Caprylyl Glycol, Glyceryl Caprylate, Disodium Edta, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.