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Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for mature skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer

High

  • HighNormal Skin Fit
  • HighEffectiveness
  • HighSafety

A great choice for mature skin; a few moisturizers fit it even better.

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Highly suitable for your normal skin, the Palmitoyl Glycine and S-Palmitoylglutathione offer antioxidant activity and barrier repair benefits, supporting rejuvenation for your wrinkles and fine lines.
  • Glycerin and Ribose provide excellent moisturizing, enhancing skin elasticity and contributing to a smoother appearance.
  • The formula is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
  • Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
  • Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
  • Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
  • Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.

People Say

★4.5Overall rating based on 500+ reviews

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

Highlights

  • Deeply hydrating Mostly Mentioned
    • “Keeps skin hydrated all day.”
    • “Great for dry patches.”
    • “Feels very moisturizing.”
  • Fast absorbing Often Mentioned
    • “Absorbs fast, not greasy.”
    • “No residue feel afterwards.”
    • “Absorbs quickly without stickiness.”
  • Pleasant texture Often Mentioned
    • “Light, velvety texture.”
    • “Not too heavy, not too light.”
    • “Creamy, not greasy.”
  • Expensive price Often Mentioned
    • “On the steep side.”
    • “More expensive side.”
    • “Price is quite high.”
  • Improves radiance Sometimes Noted
    • “Produces a radiant glow.”
    • “Skin looks healthier.”
    • “Imparts a beautiful radiance.”
  • Limited wrinkle results Sometimes Noted
    • “Haven't noticed much difference.”
    • “Not as good as advertised.”
    • “Deep lines remain.”
  • Strong fragrance Rarely Noted
    • “Fragrance too strong.”
    • “Concerned about fragrance.”
    • “Experienced minor irritation.”

Sources: lovi.care, perriconemd.com, mecca.com.au, macys.com, nordstrom.com, ipsy.com, and more

Questions and answers

What makes Perricone MD Rejuvenating Moisturizer a great fit for mature skin?

This moisturizer is a great fit for mature skin because its palmitoyl glycine and S-palmitoylglutathione help fight wrinkles and fine lines, while glycerin and ribose boost moisture and smoothness. It is very safe for your skin, with no risk of irritation from harsh ingredients.

International Journal of Cosmetic Science, 2010

Which ingredients make this cream a good fit for mature skin?

Palmitoyl Glycine and S-Palmitoylglutathione make this cream a great fit for mature skin by offering antioxidant activity and barrier repair benefits that help smooth wrinkles and fine lines. Additionally, Glycerin and Ribose provide deep moisture that enhances skin elasticity and contributes to an overall smoother appearance.

International Journal of Cosmetic Science, 2010Clinical, Cosmetic and Investigational Dermatology, 2017

What does Acyl-Glutathione do for mature skin?

Acyl-Glutathione helps mature skin by smoothing fine wrinkles and keeping the skin hydrated while providing strong antioxidant protection. Topical application of glutathione-based products is safe and may improve skin quality and brightness.

The Journal of Clinical and Aesthetic Dermatology, 2025Giornale Italiano Di Dermatologia E Venereologia, 2019

What does Vitamin C do for mature skin?

Vitamin C helps smooth out wrinkles, fade dark spots, and calm redness on mature skin. It also boosts collagen production to make skin firmer and protects against everyday environmental stress.

The Journal of Clinical and Aesthetic Dermatology, 2017Dermatologic Surgery, 2002

Where does this cream go in a skincare routine for mature skin?

This cream goes as the moisturizer step in your morning routine and your evening routine. Using a daily moisturizer helps improve skin hydration and barrier function.

The Journal of Dermatological Treatment, 2022Clinical, Cosmetic and Investigational Dermatology, 2017

Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying it after your retinol treatment to help keep your skin calm and moisturized. This approach supports your skin barrier and is unlikely to cause irritation.

Cutis, 2006

How often should I use this cream?

You can use this moisturizing treatment twice a day to help smooth fine lines and keep your mature skin well hydrated. Daily use of rich moisturizers significantly improves skin moisture, elasticity, and overall barrier function.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for mature skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts for mature skin. Its formula avoids harsh ingredients and has a safe profile that minimizes the risk of irritation.

Can I use this cream around the eyes or on my body?

You can safely use this moisturizing treatment on your face and around the eyes, though applying it to the entire body may be impractical due to its size and formulation for facial use. The product's gentle ingredients and lack of harsh irritants help smooth lines in delicate areas like the periorbital region while keeping your skin calm and comfortable.

European Journal of Pharmaceutics and Biopharmaceutics, 2014Polymers, 2023

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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