NEOCUTIS Bio Serum Firm for acne-prone skin
Rejuvenating Growth Factor
Peptides
Sodium Hyaluronate
Acetyl Glucosamine
Aminopropyl Ascorbyl Phosphate
Average
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for acne-prone skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate hydration and antioxidant benefits for your combination skin, with ingredients like Sodium Hyaluronate and Aminopropyl Ascorbyl Phosphate providing humectant and protective actions, respectively.
- The peptides present, such as Tetrapeptide-21 and Palmitoyl Tripeptide-1 Acetate, contribute to firming and plumping effects, which are secondary to your primary concern of acne, blemishes, and breakouts.
- The product is safe for your combination skin, as it contains no harsh ingredients and includes soothing components like Glycerin.
How to apply
- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.6Overall rating based on 500+ reviewsUsers frequently report significant improvements in skin texture and hydration, with many experiencing smoother skin and a reduction in fine lines and increased firmness within the first week. The product is also often praised for its hydrating and plumping effects, leaving skin with a dewy glow and appearing more radiant. While a substantial number of users find the anti-aging results to be worth the cost, the high price point is a commonly mentioned drawback.
Highlights
High price Mostly Mentioned
- “Pricey for amount”
- “Little on the pricey side”
- “Expensive growth factor serum”
Hydrating and Plumping Often Mentioned
- “Very hydrating”
- “Plumps my skin as advertised”
- “Big drink of water for my dry skin”
Improves Skin Texture Often Mentioned
- “Saw improved smoothness”
- “Skin texture has improved”
- “Makes my skin feel very smooth”
Reduces Fine Lines Often Mentioned
- “Diminishes the appearance of fine lines”
- “Softens wrinkles”
- “Less visible/apparent right away”
Fast Results Sometimes Noted
- “Saw results immediately”
- “Results in less than a week”
- “Fast results!”
Gentle on Skin Sometimes Noted
- “No issues with sensitive skin”
- “Does not cause irritation”
- “Soothing sensation”
Irritation/Reactions Rarely Noted
- “Burns when I apply it”
- “Acne came back”
- “Insaaane allergic reaction”
Lack of Results Rarely Noted
- “Not seen any difference”
- “Just garden variety humectants”
- “Results are temporary”
Product Pilling Rarely Noted
- “Causes pilling when I put anything on top”
- “Pilling”
Sources: lovi.care, lovelyskin.com, neocutis.com, dermavenue.com, reddit.com, youtube.com, and more
Questions and answers
How well does Bio Serum Firm work for acne-prone skin?
This product works for acne-prone skin, though other treatments fit it better. It offers moderate hydration and firming benefits, but acne-prone skin needs a product with ingredients like niacinamide and propolis or zinc PCA to target breakouts and control oiliness without irritation.
Which ingredients make this serum a good fit for acne-prone skin?
This serum works for acne-prone skin because it contains glycerin, which provides soothing hydration without feeling heavy. Acne-prone skin needs products with ingredients like niacinamide, zinc PCA, and propolis to target breakouts while controlling excess oil and keeping the skin balanced.
What does Growth Factor do for acne-prone skin?
Growth factor helps calm angry breakouts and visibly improves acne scars. Studies show it may reduce both red spots and clogged pores while soothing irritated skin.
What do Peptides do for acne-prone skin?
Peptides help calm acne-prone skin by reducing redness and soothing inflammation while supporting the skin barrier. Certain advanced peptide formulas also work to target acne-causing bacteria and help balance oil production.
Biochemical Pharmacology, 2025Bioresources and Bioprocessing, 2026
Where does this serum go in a skincare routine for acne-prone skin?
This serum goes in your evening routine as a treatment step after cleansing and before moisturizing. Acne-prone skin works best with products that clear breakouts and balance oil production while keeping pores clear.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first and following it with your retinol once it absorbs. This product is safe for your skin and helps soothe discomfort, though acne-prone skin ultimately needs targeted blemish-clearing ingredients and lightweight hydration to best manage breakouts.
How often should I use this serum?
This serum works best in your evening routine, applied once a day or a few times a week depending on how your skin feels. Because this product is an average fit for acne-prone skin, a product of this type for this skin needs targeted blemish-clearing ingredients like salicylic acid or benzoyl peroxide to properly address breakouts.
Can this serum clog pores, cause breakouts or purging for acne-prone skin?
This serum is unlikely to cause breakouts or purging for acne-prone skin, as it contains no harsh ingredients and includes soothing components like glycerin. However, because it focuses more on firming and plumping than clearing blemishes, acne-prone skin works best with products that offer targeted blemish control and oil-balancing ingredients.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.
Drug Delivery, 2017Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.
International Journal of Cosmetic Science, 2026A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide.
Journal of Cosmetic Dermatology, 2007N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers.
Advanced Pharmaceutical Bulletin, 2016Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants.
Journal of Cosmetic and Laser Therapy, 2019Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022
Why other serums fit acne-prone skin better
Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris.
The Journal of Clinical and Aesthetic Dermatology, 2020A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.
Clinical Pharmacology, 2018Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Glycerin, Caprylic Capric Triglyceride, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium Edta, Sodium Hydroxide, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.