MISSHA Time Revolution Night Repair Ampoule for acne-prone skin
Bifida Lysate Ferment
Niacinamide
Retinol
Copper Tripeptide-1
Ubiquinone
Average
- AverageCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for acne-prone skin; other serums fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- International Journal of Cosmetic Science, 2017
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for combination skin, as Bifida Lysate Ferment and Niacinamide help with barrier repair and oil regulation, while Glycerin and Sea Water provide general hydration supportive for acne, blemishes, and breakouts.
- The presence of retinol and adenosine offers excellent treatment for minimizing fine lines and wrinkles, addressing anti-aging concerns.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.7Overall rating based on 4.1k+ reviewsBased on a very large amount of data, this anti-aging overnight treatment is highly regarded for its ability to deeply hydrate, plump, and brighten the skin, significantly improving texture and reducing fine lines, particularly for those with dry, mature, or dull complexions. While generally well-tolerated, a moderate number of users with sensitive or acne-prone skin reported experiencing breakouts or irritation, and a small number noted a sticky or oily feel and a noticeable herbal scent.
Highlights
Deeply hydrates skin Mostly Mentioned
- “It left my skin super hydrated, absorbed into the skin quite quickly.”
- “My skin feels noticeably more hydrated compared to when I skip it.”
- “It provided great hydration for my dry skin.”
- “This serum is very moisturizing with a non sticky texture!”
Brightens and adds glow Often Mentioned
- “I wake up with glowing skin.”
- “My complexion looks noticeably brighter and clearer with regular use.”
- “Giving the skin a radiant glow.”
- “Delivers real results, improved texture, brighter tone, and a consistent morning-after glow.”
Improves skin texture Often Mentioned
- “My skin texture became noticeably smoother and more supple.”
- “My skin immediately felt softer and smoother to the touch.”
- “Consistent, measurable improvements in texture, tone, and radiance.”
- “Making skin feel smoother, softer, and highly moisturized.”
Affordable luxury dupe Sometimes Noted
- “Often compared to Estee Lauder Advanced Night Repair at a fraction of the price.”
- “This product does what more expensive products do for a lot less money.”
- “Compared it favorably to the Estee Lauder Night Repair Serum but at a more affordable price point.”
- “Achieving roughly 80% of similar results at about 25% of the price.”
May cause breakouts Sometimes Noted
- “Suddenly I started getting deep breakouts, which was disappointing.”
- “Unfortunately I developed some blemishes after using it.”
- “My cheeks kept breaking out and it stung.”
- “I'm not sure why, but I think I'm getting deep breakouts now.”
Feels sticky or oily Rarely Noted
- “It's excessively oily. There's a limit to how much oil a product should have.”
- “Doesn't absorb completely, leaving an oily residue on the surface.”
- “Minor concerns about its stickiness and absorption time.”
- “The high oil content makes it a bit overwhelming for continuous use.”
Noticeable herbal scent Rarely Noted
- “There's a faint scent, slightly floral, slightly medicinal.”
- “It contains fragrant essentials oils such as lavender, bergamot and orange oil.”
- “Possibility of skin irritation from the added essential oils.”
- “There is a very light scent but I can't really pinpoint what it is exactly.”
Sources: lovi.care, iherb.com, target.com, sokoglam.com, hwahae.com, misshaus.com, and more
Questions and answers
How well does MISSHA Time Revolution Night Repair work for acne-prone skin?
This treatment is an average fit for acne-prone skin, as it contains niacinamide and ferments that help balance oil and support skin recovery, though other products fit this skin type better. To work best for acne-prone skin, a treatment of this type needs targeted ingredients like niacinamide, zinc PCA, propolis, or antioxidants that manage breakouts and keep skin balanced without causing excess oiliness or dryness.
Which ingredients make this serum a good fit for acne-prone skin?
Bifida Lysate Ferment and Niacinamide help with barrier repair and oil regulation, while Glycerin and Sea Water provide general hydration. Acne-prone skin needs ingredients like niacinamide and propolis that provide excellent skincare benefits for acne and breakouts, while ensuring no risk of irritation.
What does Bifida Ferment Lysate do for acne-prone skin?
Bifida Ferment Lysate helps acne-prone skin by calming redness and keeping the skin barrier strong. This ingredient may also support the skin's defenses against irritation, making it less likely to flare up.
Journal of Cosmetic Dermatology, 2023Experimental Dermatology, 2010
What does Niacinamide do for acne-prone skin?
Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Where does this serum go in a skincare routine for acne-prone skin?
This treatment goes in the evening routine after cleansing and before moisturizing, applied as part of your nighttime steps. To best support acne-prone skin, a product of this type needs barrier-repairing ingredients like bifida lysate ferment and niacinamide along with hydrating elements like glycerin and sea water.
Can I use this serum with AHA, and in what order?
You can use this treatment alongside an AHA, but because it contains retinol, it may increase the likelihood of dryness or irritation on acne-prone skin. Apply the AHA first on clean skin, let it absorb, and then follow with this treatment to keep your routine balanced. Acne-prone skin generally needs soothing ingredients like niacinamide and gentle hydrators to calm potential irritation from strong active combinations.
How often should I use this serum?
This treatment is used in the evening routine. Acne-prone skin works best with products that offer soothing ferment ingredients, gentle barrier support, and lightweight hydration to help keep blemishes calm and clear.
Can this serum clog pores, cause breakouts or purging for acne-prone skin?
This serum may cause breakouts for acne-prone skin, as some reviewers note this issue. To better fit acne-prone skin, a product of this type needs soothing ingredients like niacinamide and lightweight hydrators that balance oil without heavy oils.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.
Archives of Dermatological Research, 2017Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.
Archives of Facial Plastic Surgery, 2006A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.
Cureus, 2024The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.
Skin Research and Technology, 2026Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism.
BioFactors, 2008Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects.
Colloids and Surfaces. B, Biointerfaces, 2023Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects.
Antioxidants, 2021
Ingredients
Water, Bifida Lysate Ferment, Glycereth-26, Juniperus Chinensis Xylem Extract, Sorbus Commixta Extract, Bis-Peg-18 Methyl Ether Dimethyl Silane, Butylene Glycol, Glycerin, Niacinamide, Betaine, Leuconostoc Radish Ferment Filtrate, Cyclopentasiloxane, Ethyl Hexanediol, Dimethicone, Grifola Frondosa Extract Ferment Filtrate Maitake Extract Ferment Filtrate Ophioglossum Vulgatum Extract Ferment Filtrate, Peg-11 Methyl Ether Dimethicone, Peg-40 Hydrogenated Castor Oil, Ppg-26-Buteth-26, Polysorbate 20, Carbomer, Glyceryl Caprylate, Triethanolamine, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Dimethicone Vinyl Dimethicone Crosspolymer, Hydrolyzed Rice Extract, Lactobacillus Rice Ferment Filtrate, Portulaca Oleracea Extract, Sea Water, Sodium Hyaluronate, Octyldodecanol, Carthamus Tinctorius Oleosomes, Acacia Arabica Bark Extract Stem, Hydrolyzed Extensin, Adenosine, Xanthan Gum, Aronia Arbutifolia Extract, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Blueberry Fruit Extract, Dipropylene Glycol, Echium Plantagineum Seed Oil, Tocopheryl Acetate, Cyclomethicone, Hydrogenated Lecithin, Disodium Edta, Ascorbyl Tetraisopalmitate, Dextrin, Lactobacillus Ferment, Lactococcus Lysate Ferment, Laminaria Digitata Extract, Manilkara Multinervis Leaf Extract, Theobroma Cacao Seed Extract, Lauryl Methacrylate Glycol Dimethacrylate Crosspolymer, Saccharomyces Ferment Filtrate, Lactobacillus Soybean Extract Ferment, Glyceryl Polyacrylate, Saccharomyces Viscum Album Extract Ferment Mistletoe Extract Ferment, Yeast Extract Ferment, Pogostemon Cablin Oil, Dimethiconol, Cardiospermum Halicacabum Vine Extract Flower Leaf, Helianthus Annuus Seed Oil Sunflower Seed Oil, Pseudoalteromonas Extract Ferment, Alpha-Glucan Oligosaccharide, Limnanthes Alba Seed Oil, Hydrolyzed Wheat Protein, Beta-Sitosterol, Panthenol, Hydrolyzed Soy Protein, Propylene Glycol, Cholesterol, Ceteth-24, Choleth-24, Glyceryl Arachidonate, Glyceryl Linoleate, Glyceryl Linolenate, Ubiquinone, Hydroxypropyltrimonium Maltodextrin Crosspolymer, Cetyl Phosphate, Caprylic Capric Triglyceride, Macadamia Ternifolia Seed Oil, Retinol, Lecithin, Phenoxyethanol, Cucumis Melo Fruit Extract, Amaranthus Caudatus Seed Extract, Biotin, Brassica Campestris Sterols, Peg-5 Rapeseed Sterol, Sodium Ascorbyl Phosphate, Tripeptide-10 Citrulline, Acetyl Hexapeptide-8, Bht, Ceteth-3, Ceteth-5, Copper Tripeptide-1, Silica, Tripeptide-1
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Dr. Sofía Perea Pérez, MD, MSc
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Elina Nazarenko, MD
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Victoria Derkova, MS
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