MEDIHEAL Madecassoside Essential Mask for mature skin

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What the research says

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Facial masks containing low-temperature extracted Portulaca oleracea protect sensitive skin from photothermal stimulation and improve skin barrier function during photorejuvenation.

  Cutaneous and Ocular Toxicology, 2025

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.

  Clinical Pharmacology, 2018

• Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief.

  Plastic and Reconstructive Surgery, 2018

• Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo.

  Journal of Alternative and Complementary Medicine, 2010

• Topical CE Ferulic plus resveratrol BE serum following ablative fractional CO2 laser treatment reduced erythema index (308.9 vs. 325.3), shortened complete scabbing detachment time (6.0 vs. 6.5 days), decreased melanin index (-7.4% vs. +0.2%), and improved skin hydration compared to normal saline in 51 Chinese patients.

  Journal of the European Academy of Dermatology and Venereology, 2024

• Topical treatment with a combination of pyridine-2, 4-dicarboxylic acid diethyl ester and resveratrol significantly increased hair density in 79 Caucasian female subjects starting from 1.5 months compared to baseline.

  International Journal of Cosmetic Science, 2020

• A nighttime topical antioxidant containing resveratrol, baicalin, and vitamin E significantly improved fine lines, wrinkles, firmness, elasticity, laxity, hyperpigmentation, radiance, roughness, and dermal thickness in subjects with mild to moderately photodamaged skin over 12 weeks.

  Journal of Drugs in Dermatology, 2014

Ingredients

Water, Niacinamide, Propanediol, Dipropylene Glycol, 1,2-Hexanediol, Hydroxyacetophenone, Trehalose, Glycerin, Sodium Acrylic Acid Ma Copolymer, Butylene Glycol, Disodium Edta, Carbomer, Arginine, Octyldodeceth-16, Xanthan Gum, Caprylyl Glycol, Glycine, Glutamic Acid, Centella Asiatica Extract, Madecassoside, Aspartic Acid, Anthemis Nobilis Flower Extract, Portulaca Oleracea Extract, Gluconolactone, Sodium Polyacrylate, Sodium Chloride, Resveratrol, Centella Asiatica Stem Extract Flower Leaf, Centella Asiatica Leaf Extract, Centella Asiatica Root Extract, Saccharomyces Ferment, Histidine, Serine, Alanine, Threonine, Proline, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Asiaticoside, Magnesium Chloride, Calcium Chloride, Aloe Barbadensis Leaf Juice, Asiatic Acid, Madecassic Acid

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.