DRMTLGY Peptide Night Cream for dry sensitive skin
Peptides
Ceramides
Shea Butter
Tocopherol Vitamin E
Allantoin
Superior
- SuperiorDry Skin Fit
- SuperiorEffectiveness
- ExcellentSafety
One of the best moisturizers for dry sensitive skin.
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your dry and sensitive skin as multiple peptides like Palmitoyl Tetrapeptide-7 and Palmitoyl Tripeptide-1, along with ceramides, are present in high concentrations to enhance barrier resilience and hydration, effectively addressing dryness and flakiness.
- Glycerin and shea butter further support humectant and emollient actions, providing deep nourishment and comfort for dry skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.
How to apply
- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
People Say
★4.9Overall rating based on 2.4k+ reviewsBased on a very large amount of data, this fragrance-free night cream is highly regarded for its rich yet non-greasy texture, providing deep hydration and plumping effects. Users frequently report improvements in skin texture, reduced fine lines, and a strengthened moisture barrier, making it suitable for sensitive and aging skin types. Some users find the jar packaging unhygienic, and a few with very dry skin may require additional moisture, while others note it can be too heavy for daytime use. Availability can also be a concern due to frequent sell-outs.
Highlights
Deep hydration Mostly Mentioned
- “quenches skin's thirst”
- “woke up glowing”
- “no more dry patches”
Gentle formula Often Mentioned
- “no irritation”
- “fragrance-free”
Non-greasy texture Often Mentioned
- “soaks right in”
- “fluffy texture”
- “lightweight but rich”
Anti-aging benefits Sometimes Noted
- “softens fine lines”
- “skin looks younger”
- “improves skin elasticity”
Value for money Sometimes Noted
- “better than high-end”
- “great price point”
- “affordable luxury”
Jar packaging Sometimes Noted
- “wish it had a pump”
- “don't like dipping fingers”
- “prefer airless dispenser”
Availability issues Rarely Noted
- “shipping takes time”
- “only available online”
- “sold out frequently”
Not rich enough Rarely Noted
- “need to layer oil”
- “not enough for winter”
- “dried out by morning”
Too heavy for day Rarely Noted
- “too thick for day”
- “shiny under makeup”
- “strictly a night cream”
Sources: lovi.care, drmtlgy.com, amazon.com, reddit.com, youtube.com, makeupalley.com, and more
Questions and answers
What makes DRMTLGY Peptide Night Cream one of the best fits for dry sensitive skin?
This cream is an exceptional fit for dry sensitive skin because it uses high concentrations of peptides and ceramides to repair your moisture barrier and stop flakiness. Glycerin and shea butter add deep nourishment to leave your skin feeling soft and comfortable. It is also very safe for your skin, as it avoids harsh ingredients and includes soothing components.
Which ingredients make this cream a good fit for dry sensitive skin?
Peptides and ceramides make this cream a great fit for dry sensitive skin by strengthening your moisture barrier and easing flakiness. Shea butter and glycerin add deep nourishment, while soothing ingredients like allantoin help keep your skin calm and comfortable.
What do Peptides do for dry sensitive skin?
Peptides help hydrate dry sensitive skin while smoothing the look of fine lines and keeping the surface calm. They may also improve skin elasticity, though some types need enhanced delivery systems to deeply penetrate the skin barrier.
Advanced Science, 2025International Journal of Molecular Sciences, 2025
What do Ceramides do for dry sensitive skin?
Ceramides help strengthen dry, sensitive skin by locking in moisture and repairing the outer barrier, which makes skin feel softer and less irritated. This type of care helps prevent dryness and keeps skin calm and comfortable.
The British Journal of Dermatology, 2022Journal of Cosmetic Dermatology, 2025
Where does this cream go in a skincare routine for dry sensitive skin?
This cream goes in the evening routine as a treatment step, applied after your toner and before your moisturizer. It is unlikely to cause irritation and helps improve hydration and barrier strength for dry skin.
Can I use this cream with retinol, and in what order?
Yes, you can use this cream with retinol, and applying it either before or after retinol helps calm the skin and reduce dryness. The ceramides and soothing ingredients in this cream support the skin barrier while you use retinoids, making irritation less likely.
How often should I use this cream?
You can use this moisturizing treatment daily in your evening routine to deeply nourish and soften dry, sensitive skin. Applying it regularly helps strengthen your skin barrier and is unlikely to cause irritation.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for dry sensitive skin?
This cream is unlikely to clog pores or cause breakouts for your dry sensitive skin. Its formulation focuses on nourishing and soothing ingredients that hydrate without harsh components, keeping your skin calm and comfortable.
Can I use this cream around the eyes or on my body?
Yes, you can use this moisturizing treatment around your eyes and on your body because its gentle formula is safe and well-tolerated by sensitive skin. The cream is unlikely to cause irritation while deeply nourishing dry areas, making it suitable for delicate facial zones and broader skin.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.
What the research says
A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Application of Body Lotion for 5 weeks on cosmetic dry skin improved barrier properties, increased levels of cholesterol, ceramides, and long-chain fatty acids, increased beneficial skin bacteria, and enhanced microbiome functional potential compared to baseline.
Scientific Reports, 2022A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.
Lasers in Medical Science, 2025A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.
International Journal of Cosmetic Science, 2025Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.
Aesthetic Plastic Surgery, 2018
Ingredients
Water, Glyceryl Stearate, Propanediol, C12-15 Alkyl Benzoate, Glycerin, Isopropyl Palmitate, Undecane, Butyrospermum Parkii Butter Shea Butter, Caprylic Capric Triglyceride, Cetyl Alcohol, Dimethicone, Peg-100 Stearate, Ceramide Eop, Ceramide Ap, Palmitoyl Tetrapeptide-7, Ceramide Np, Palmitoyl Tripeptide-1, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-5, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Allantoin, Phytosphingosine, Cholesterol, Tridecane, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Glycol Distearate, Ethylhexylglycerin, Potassium Cetyl Phosphate, Carbomer, Sodium Hydroxide, Disodium Edta, Sodium Lauroyl Lactylate, Polysorbate 20, Dextran, Xanthan Gum, Phenoxyethanol, Magnesium Chloride
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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