Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol · American Journal of Clinical Dermatology, 2002Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Tocopherol · Journal of Cosmetic Dermatology, 2020Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
Chamomile extract · International Journal of Molecular Medicine, 2016Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation
Papain · The Journal of Investigative Dermatology, 2015Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Aloe barbadensis leaf powder · Clinical Pharmacology, 2018The topical effect of grape seed extract 2% cream on surgery wound healing
Palmitoyl grape seed extract · Global Journal of Health Science, 2014Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np · International Journal of Dermatology, 2008Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Tocopherol · Journal of Cosmetic Dermatology, 2020Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy
Vitis vinifera juice grape juice, Resveratrol, Grape extract · Molecules, 2023Role of Resveratrol in Regulating Cutaneous Functions
Vitis vinifera juice grape juice · Evidence-based Complementary and Alternative Medicine, 2020Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin
Centella asiatica leaf extract · Experimental Dermatology, 2008α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis
Palmitoyl grapevine shoot extract · Theranostics, 2018The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021Resveratrol as a factor preventing skin aging and affecting its regeneration
Vitis vinifera juice grape juice · Postepy Dermatologii I Alergologii, 2022Oleanolic Acid Protects the Skin from Particulate Matter-Induced Aging
Oleanolic acid · Biomolecules & Therapeutics, 2021Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging
Bentonite · Carbohydrate Polymers, 2017Development of Polymeric Micelles of Oleanolic Acid and Evaluation of Their Clinical Efficacy
Oleanolic acid · Nanoscale Research Letters, 2020Evaluation of dermatological effects of cosmetic formulations containing Saccharomyces cerevisiae extract and vitamins
Vinolevure · Food and Chemical Toxicology, 2008Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid · BioMed Research International, 2020Formulation and evaluation on human skin of a water-in-oil emulsion containing Muscat hamburg black grape seed extract
Palmitoyl grape seed extract, Grape seed oil · International Journal of Cosmetic Science, 2015Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study
Glycolic acid · Journal of Cosmetic Dermatology, 2019A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol · The Journal of Dermatological Treatment, 2017Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation
Parfum · Pharmaceuticals, 2023Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine · International Journal of Cosmetic Science, 2018Hydroxypropyl methylcellulose hydrogel of berberine chloride-loaded escinosomes: Dermal absorption and biocompatibility
Enantia chlorantha bark extract · International Journal of Biological Macromolecules, 2020The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy
Centella asiatica leaf extract · Molecules, 2023Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function
Rosmarinus officinalis oil leaf rosemary oil leaf · International Journal of Molecular Sciences, 2022Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid · Journal of Cosmetic Dermatology, 2024Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications
Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
Ceramide np · Skin Pharmacology and Physiology, 2022Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin
Acetyl dipeptide-1 cetyl ester · Journal of the European Academy of Dermatology and Venereology, 2016Pentacyclic triterpenes from Terminalia arjuna show multiple benefits on aged and dry skin
Terminalia arjuna extract · Skin Pharmacology and Physiology, 2014A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid · Journal of Drugs in Dermatology, 2023Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial
Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Citric acid · Journal of Cosmetic Dermatology, 2021Oleanolic Acid Nanofibers Attenuated Particulate Matter-Induced Oxidative Stress in Keratinocytes
Oleanolic acid · Antioxidants, 2021Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin
Butylene glycol · Journal of Cosmetic Dermatology, 2019Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine · Journal of Cosmetic Dermatology, 2019Development of grape seed extract based formulations by using non-invasive biophysical technique and its impact on skin aging
Grape seed oil · Pakistan Journal of Pharmaceutical Sciences, 2021Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment
Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil
Rosa damascena oil flower · Acta Pharmaceutica, 2013Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres
Papain · Giornale Italiano Di Dermatologia E Venereologia, 2015Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis
Vinolevure · Journal of Clinical Medicine, 2023Dyspigmentation, skin physiology, and a novel approach to skin lightening
Vinolevure · Journal of Cosmetic Dermatology, 2013Clinical study of Asian skin changes after application of a sunscreen formulation containing grape seed extract
Palmitoyl grape seed extract · Journal of Cosmetic Dermatology, 2022Topical Almond Oil for Prevention of Pressure Injuries: A Single-Blinded Comparison Study
Prunus amygdalus dulcis oil · Journal of Wound, Ostomy, and Continence Nursing, 2020Anti-inflammatory and skin-hydrating properties of a dietary supplement and topical formulations containing oligomeric proanthocyanidins
Grape seed oil · Skin Pharmacology and Physiology, 2007Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol · Journal of Cosmetic Dermatology, 2025Genotoxicity of micro- and nano-particles of kaolin in human primary dermal keratinocytes and fibroblasts
Purifying clay · Genes and Environment, 2020Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine · International Journal of Molecular Sciences, 2026Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride · Life, 2023Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Citric acid · Journal of Drugs in Dermatology, 2013Dirt-binding particles consisting of hydrogenated castor oil beads constitute a nonirritating alternative for abrasive cleaning of recalcitrant oily skin contamination in a three-step programme of occupational skin protection
Castor oil · The British Journal of Dermatology, 2010Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin
Melissa officinalis oil · Photodermatology, Photoimmunology & Photomedicine, 2025A method for maintaining the clinical results of 4% hydroquinone and 0.025% tretinoin with a cosmeceutical formulation
Vinolevure · Journal of Drugs in Dermatology, 2015Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021The effect of different formulations of equivalent active ingredients on the performance of two topical wound treatment products
Castor oil · Ostomy/wound Management, 2004The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial
Bentonite · Journal of Cosmetic Dermatology, 2025Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Butyrospermum parkii butter extract shea butter extract, Shea butter extract, Saccharide isomerate · Lasers in Medical Science, 2025Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking
Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study
Saccharide isomerate · The Journal of Dermatological Treatment, 2025Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population
Saccharide isomerate · Journal of Cosmetic Dermatology, 2023The harnessing potential of carboxymethyl beta glucan: A driver of skin repair
Sodium carboxymethyl betaglucan · International Journal of Cosmetic Science, 2026