🇸🇦Saudi Arabia

VT Cosmetics PDRN Essence 100 for acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

VT Cosmetics PDRN Essence 100

Average

  • HighCombination Skin Fit
  • AverageEffectiveness
  • ExcellentSafety

Works for acne-prone skin; other serums fit it better.

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate skin regeneration for your combination skin, as PDRN Polydeoxyribonucleotide and Sodium Hyaluronate promote skin repair and hydration, while Niacinamide helps regulate oil production.
  • General skincare benefits like hydration from Sodium Hyaluronate and soothing from Allantoin support your acne and blemishes, though targeted ingredients for direct concern resolution are absent.
  • The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Sodium Hyaluronate and Panthenol.

How to apply

  • Use your serum as part of your PM routine and start 3x/week before working up to daily use.
  • Apply this treatment after cleansing and toner, and before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • Apply the product on clean, dry skin to help manage your breakouts safely.
  • Avoid the eye area and do a patch test before your first use.

People Say

★4.8Overall rating based on 1.6k+ reviews

Based on a very large amount of data, users with dry, sensitive, and combination skin highly praise this essence for its ability to deliver a glass skin finish and deep hydration without irritation. It is widely celebrated for restoring compromised barriers and plumping fine lines. A minority of users with oily skin find the texture too heavy or tacky.

Highlights

  • Hydration and glow Mostly Mentioned
    • “Instant glass skin”
    • “deeply moisturizing”
    • “plumps fine lines”
    • “radiant finish”
  • Soothing and repair Often Mentioned
    • “Calms redness”
    • “heals breakouts”
    • “strengthens barrier”
    • “non-irritating”
  • Fragrance-free Sometimes Noted
    • “No scent”
    • “great for sensitive noses”
    • “unscented”
    • “no artificial fragrance”
  • Good texture Sometimes Noted
    • “Milky consistency”
    • “absorbs quickly”
    • “lightweight feel”
    • “layers well”
  • Sticky finish Sometimes Noted
    • “Feels sticky”
    • “tacky residue”
    • “hair sticks to face”
    • “takes time to dry”
  • Nice packaging Rarely Noted
    • “Airless pump”
    • “hygienic design”
    • “easy to dispense”
    • “cute bottle”
  • Caused breakouts Rarely Noted
    • “Caused whiteheads”
    • “clogged pores”
    • “broke me out”
    • “small bumps”
  • Expensive price Rarely Noted
    • “A bit pricey”
    • “expensive for size”
    • “waited for sale”
    • “costly”
  • Pump design Rarely Noted
    • “Pump drips”
    • “messy dispenser”
    • “squirts everywhere”
    • “hard to control”
  • Texture issues Rarely Noted
    • “Too thick”
    • “hard to spread”
    • “heavy for oily skin”
    • “feels gloopy”

Sources: lovi.care, oliveyoung.com, stylekorean.com, skinsort.com, reddit.com, yesstyle.com, and more

Questions and answers

How well does VT PDRN Essence 100 work for acne-prone skin?

VT PDRN Essence 100 works moderately well for acne-prone skin, providing gentle hydration and soothing care through ingredients like Sodium Hyaluronate and Allantoin. While it helps calm and support your skin safely without causing irritation, it lacks targeted ingredients for direct breakout resolution. Acne-prone skin typically needs products with effective ingredients like niacinamide and propolis that provide excellent skincare benefits for acne and breakouts while controlling oiliness.

American Journal of Clinical Dermatology, 2002Journal of Pharmacy & Pharmaceutical Sciences, 2015

Which ingredients make this treatment a good fit for acne-prone skin?

Pdrn Polydeoxyribonucleotide and Sodium Hyaluronate help repair your skin and keep it hydrated, while Niacinamide helps control oil. This treatment for acne-prone skin needs ingredients like propolis or zinc pca to target breakouts directly while maintaining moisture and balance without causing excess oiliness.

Journal of Pharmacy & Pharmaceutical Sciences, 2015American Journal of Clinical Dermatology, 2002

What does PDRN do for acne-prone skin?

PDRN helps calm acne-prone skin by supporting barrier recovery and improving overall skin condition. It is unlikely to clog pores and may assist with soothing irritated areas.

International Journal of Molecular Sciences, 2025Pharmaceutics, 2025

What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.

Biomedicines, 2025Drug Delivery, 2017

Where does this treatment go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps it simple and safe for your skin. It is very unlikely to cause irritation because it lacks harsh ingredients and includes soothing components. Acne-prone skin works best with a treatment that includes targeted blemish-fighting ingredients and oil-balancing components.

International Journal of Cosmetic Science, 2020

Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first and then following with your retinol. This product is unlikely to cause irritation because it contains soothing components like Sodium Hyaluronate and Panthenol.

How often should I use this treatment?

You can use this treatment in your evening routine, as this type of product is typically applied at night for simplicity and extra safety around sun exposure. For acne-prone skin, a product of this type needs targeted ingredients for direct concern resolution, along with soothing components and oil-regulating ingredients.

Can this treatment clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to cause breakouts because it has a very safe formula with soothing ingredients like panthenol and sodium hyaluronate, though a few reviewers have reported breakouts. Acne-prone skin needs products with targeted active ingredients to directly clear blemishes and regulate oil production.

American Journal of Clinical Dermatology, 2002Journal of Pharmacy & Pharmaceutical Sciences, 2015

Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine.

    Journal of Pharmacy & Pharmaceutical Sciences, 2015

  • A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.

    Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

  • Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

    American Journal of Clinical Dermatology, 2002

  • A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

    The Journal of Dermatological Treatment, 2017

  • A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

    Journal of Cosmetic Dermatology, 2025

  • Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.

    International Journal of Molecular Sciences, 2025

  • Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.

    Molecular Medicine Reports, 2023

  • A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.

    Molecules, 2022

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

    The Journal of Dermatology, 2008

  • Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

    International Journal of Molecular Sciences, 2026

  • Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

    International Journal of Molecular Sciences, 2021

Why other serums fit acne-prone skin better

Ingredients

Water, Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Allantoin, Adenosine, Betaine, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Triethanolamine

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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Prices checked 5 Nov 2026

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Saudi Arabia.

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
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