Perricone MD Deep Crease Serum for sensitive skin
Acyl-Glutathione- S-Palmitoylglutathione
Tetrahexyldecyl Ascorbate
Palmitoyl Tripeptide-5
Acetyl Hexapeptide-8
Average
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This product offers moderate benefits for your normal skin, with S-Palmitoylglutathione and Tetrahexyldecyl Ascorbate providing antioxidant activity and supporting collagen synthesis to address fine lines and wrinkles.
- Glycerin and Squalane offer general hydration and soothing effects that can support your redness and irritation, though they are not specifically targeted for these concerns.
- The safety profile is excellent, with no risks of irritation for your sensitive skin due to the absence of harsh ingredients and the presence of soothing components.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.5Overall rating based on 800+ reviewsUsers in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.
Highlights
Lightweight texture Mostly Mentioned
- “Absorbs quickly”
- “not sticky or greasy”
- “feels silky and smooth”
Hydrating formula Often Mentioned
- “Skin drinks it up”
- “leaves skin feeling plump”
- “adds a boost of moisture”
Softens deep lines Often Mentioned
- “Deeper lines look softer”
- “smile lines appear less pronounced”
- “frown lines look less visible”
High price point Often Mentioned
- “Price is quite premium”
- “barrier for some”
- “expensive investment”
Improves firmness Sometimes Noted
- “Skin feeling firmer”
- “noticeable improvement in bounce”
- “more lifted look”
Dropper issues Sometimes Noted
- “Difficult to pick up product”
- “dropper doesn't work well”
- “inconsistent dispensing”
Gradual results Sometimes Noted
- “Not an overnight miracle”
- “results are subtle”
- “haven't seen 11s improve yet”
Fragrance sensitivity Rarely Noted
- “Rose scent may not be ideal”
- “not for those with fragrance allergies”
Sources: lovi.care, perriconemd.com, dermstore.com, ulta.com, youtube.com, reddit.com, and more
Questions and answers
How well does Perricone MD Deep Crease Serum work for sensitive skin?
This product works for sensitive skin, though other products fit it better because they target redness and irritation more effectively. Treatments that fit this skin well need soothing ingredients like niacinamide and snail secretion filtrate to calm redness while supporting skin health.
Which ingredients make this serum a good fit for sensitive skin?
Glycerin and squalane help provide general hydration and soothing effects that can support sensitive skin, while an absence of harsh ingredients helps maintain a very safe profile. To best fit sensitive skin, treatments of this type need soothing components and ingredients that specifically target redness and irritation.
What does Acyl-Glutathione do for sensitive skin?
Acyl-glutathione helps protect sensitive skin by reducing oxidative stress and fighting environmental damage, though a product for this skin type also needs soothing ingredients to calm irritation and strengthen the skin barrier.
Journal of the European Academy of Dermatology and Venereology, 2024Journal of Cosmetic Dermatology, 2026
What does Palmitoyl Glutathione do for sensitive skin?
Palmitoyl glutathione helps keep sensitive skin calm and smooth by supporting its natural antioxidant defenses and moisture balance. This type of ingredient may improve skin texture and reduce irritation, though results vary depending on the product's overall formula.
Where does it go in a skincare routine for sensitive skin?
This treatment goes in the evening routine after your toner and before your moisturizer. It is unlikely to cause irritation for your sensitive skin because it lacks harsh ingredients and contains soothing components, though a product for this skin also needs gentle hydrating and calming ingredients.
Can I use this serum with retinol, and in what order?
Perricone MD Deep Crease Serum may be used alongside retinol by applying it in your evening routine after cleansing and toning, and before moisturizing. This product is unlikely to irritate sensitive skin because it lacks harsh ingredients and includes soothing components. However, sensitive skin needs a treatment with higher amounts of calming agents and gentle hydrators to manage redness and irritation effectively.
How often should I use it?
This treatment is used in the evening once a day, and sensitive skin needs a product with gentle antioxidants, hydrating glycerin, and soothing ingredients like squalane to help address fine lines while keeping redness calm.
European Journal of Pharmaceutics and Biopharmaceutics, 2017
Can this serum clog pores, cause breakouts or purging for sensitive skin?
This serum is unlikely to clog pores or cause breakouts on sensitive skin, as it has an excellent safety profile and contains no harsh ingredients. To care for sensitive skin best, a treatment product of this type needs calming agents and gentle hydrators like glycerin and squalane to keep the skin comfortable without triggering irritation.
Is it fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).
What the research says
A 3-in-1 anti-aging topical night serum-in-oil applied once daily decreased wrinkles by 11%, increased skin firmness by 8%, reduced redness by 70%, and improved overall skin quality and complexion in 103 female subjects over 28 to 84 days compared to baseline.
Journal of Cosmetic Dermatology, 2019Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Topical formulations containing ascorbyl tetraisopalmitate, coenzyme Q10, green tea polyphenols, and resveratrol reduced the release of inflammatory cytokines and attenuated inflammatory signs compared to untreated skin and vehicle in 25 Japanese volunteers exposed to sodium dodecyl sulfate.
European Journal of Pharmaceutics and Biopharmaceutics, 2017Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects.
Colloids and Surfaces. B, Biointerfaces, 2025Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017
Ingredients
Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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