numbuzin 5 Glutathione Vitamin Concentrated Serum for skin with dark spots
Glutathione
Niacinamide
3-O-Ethyl Ascorbic Acid
Tranexamic Acid
Alpha-ArbutinHigh
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
A great choice for skin with dark spots; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your normal skin, this serum effectively targets pigmentation concerns with key ingredients like Tranexamic Acid and Alpha-Arbutin, which work to visibly brighten and even out skin tone.
- Niacinamide and Panthenol further support your skin barrier and provide essential hydration, enhancing the overall efficacy for your complexion.
- The formulation is safe for your skin, containing no harsh or irritating ingredients.
How to apply
- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
People Say
★4.7Overall rating based on 2.0k+ reviewsBased on a very large amount of data, users with dullness, hyperpigmentation, and sensitive skin frequently praise this serum for its ability to fade acne scars and even out skin tone without causing irritation. The majority report a "glass skin" glow and rapid absorption, while a small minority experienced breakouts or found the brightening effects too slow to appear.
Highlights
Fades dark spots Mostly Mentioned
- “Acne marks faded noticeably”
- “Helps with pigmentation issues”
- “Sunspots have faded”
- “Clear up hyperpigmentation”
- “Reduces appearance of spots”
Gentle on skin Often Mentioned
- “No irritation”
- “Great for sensitive skin”
- “Gentle yet effective”
- “No stinging”
- “Soothing ingredients”
Lightweight texture Often Mentioned
- “Absorbs instantly”
- “Non-sticky formula”
- “Lightweight milky texture”
- “Sinks in quickly”
- “Does not feel heavy”
Hydrating glow Sometimes Noted
- “Natural glass-skin glow”
- “Leaves skin soft”
- “Very hydrating”
- “Restores natural glow”
- “Dewy finish”
Caused breakouts Rarely Noted
- “Caused tiny bumps”
- “More acne on my skin”
- “Triggered whiteheads”
- “Broke me out”
- “Clogged my pores”
Packaging issues Rarely Noted
- “Dropper is messy”
- “Hard to get last drops”
- “Bottle leaks slightly”
Slow results Rarely Noted
- “Did nothing to brighten”
- “No big improvement”
- “Takes a long time”
- “Saw no difference”
- “Overhyped results”
Tacky finish Rarely Noted
- “Left a slightly tacky feeling”
- “Sticky residue”
- “Felt heavy initially”
- “Greasy after application”
Sources: lovi.care, oliveyoung.com, iherb.com, stylevana.com, yesstyle.com, reddit.com, and more
Questions and answers
What makes numbuzin 5 Serum a great fit for skin with dark spots?
This serum is a great fit because it uses key ingredients like Tranexamic Acid and Alpha-Arbutin to visibly brighten and even out skin tone. Niacinamide and Panthenol further support your skin barrier and provide essential hydration to help improve your complexion.
Which ingredients make this serum a good fit for skin with dark spots?
This serum is a great fit for skin with dark spots because it features Tranexamic Acid and Alpha-Arbutin to visibly brighten and even out your skin tone. Niacinamide and Panthenol further support your skin barrier and provide essential hydration to enhance your complexion.
What does Glutathione do for skin with dark spots?
Glutathione helps brighten skin with dark spots and evens out skin color. Topical and oral use may reduce dark patches and protect against environmental stress with a good safety profile.
Journal of Cosmetic Dermatology, 2019International Journal of Dermatology, 2025
What does Niacinamide do for skin with dark spots?
Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Where does this serum go in a skincare routine for skin with dark spots?
This serum goes in your evening routine as a treatment step after cleansing and toning, and before your moisturizer. Using treatments in the evening helps keep things simple and provides extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first and following it with your retinol. Because this formula is gentle and free of harsh ingredients, it is unlikely to irritate your skin when combined.
How often should I use this serum?
You can use this serum in your evening routine, and some people also use it in the morning or twice a day. It has a great fit for skin with dark spots, and its formulation is safe and free of harsh or irritating ingredients.
Can this serum clog pores, cause breakouts or purging for skin with dark spots?
This serum is unlikely to cause breakouts, as very few reviewers report this issue and the formula contains no harsh ingredients. It helps brighten dark spots while supporting your skin barrier without clogging pores.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Behenyl alcohol is a fatty alcohol, which soften the skin.
What the research says
Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations.
Heliyon, 2023A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.
Journal of Cosmetic Dermatology, 2025A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability.
Journal of Cosmetic Science, 2020Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants.
Journal of Cosmetic Dermatology, 2025Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation.
Biomaterials Science, 2023
Ingredients
Vaccinium Vitis-Idaea Fruit Extract, Butylene Glycol, Niacinamide, Panthenol, Tranexamic Acid, Water, 1,2-Hexanediol, Neopentyl Glycol Dicaprate, Caprylic Capric Triglyceride, Sorbitol, Bifida Ferment Filtrate, Chondrus Crispus Extract, Butyrospermum Parkii Butter, Saccharum Officinarum Extract, Alpha-Arbutin, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Tremella Fuciformis Extract, Pentylene Glycol, Glycerin, 3-O-Ethyl Ascorbic Acid, Alpha Bisabolol, Tromethamine, Ethylhexylglycerin, Adenosine, Hydrogenated Lecithin, Allantoin, Glutathione, Ceramide Np, Beta-Glucan, Dipotassium Glycyrrhizate, Tocopherol, L Ascorbic Acid, Ascorbyl Glucoside, Tocopheryl Acetate, Hydroxypropyl Cyclodextrin, Ubiquinone, Alpha Lipoic Acid, Potassium Hydroxide, Behenyl Alcohol, Carbomer, Xanthan Gum, Disodium Edta
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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