Natura Bissé C+C Vitamin Complex for sensitive skin
Ascorbic Acid
Vitamin E
Rosa Canina Oil Fruit
Hydrolyzed CollagenLow
- HighNormal Skin Fit
- AverageEffectiveness
- Low RiskSafety
A weak match for sensitive skin; the serums alongside fit it better.
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate skin brightening for your normal skin due to Sodium Ascorbyl Phosphate and Tocopheryl Acetate, which provide antioxidant activity and support barrier repair. While these ingredients offer general skincare benefits, they are not specifically targeted to address your redness and irritation.
- The formula is generally safe for your sensitive skin as it lacks harsh or prohibited ingredients, ensuring no risks of irritation.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.5Overall rating based on 100+ reviewsBased on limited data, users consistently praise this serum for its potent brightening abilities, noting that it effectively revitalizes dull, tired-looking skin and improves overall radiance. The lightweight, fast-absorbing texture is a hit, though some users with sensitive skin caution against potential irritation due to the high concentration of Vitamin C and strong citrus fragrance.
Highlights
Brightens dull skin Often Mentioned
- “Instant glow”
- “revitalizes complexion”
- “looks less tired”
- “radiant finish”
High price Often Mentioned
- “Very expensive”
- “pricey investment”
- “luxury cost”
- “wallet hurting”
Lightweight texture Sometimes Noted
- “Absorbs immediately”
- “non-greasy”
- “silky feel”
- “light fluid”
Pleasant scent Sometimes Noted
- “Fresh citrus smell”
- “smells like oranges”
- “uplifting fragrance”
- “energizing scent”
Potential irritation Sometimes Noted
- “Stung slightly”
- “redness on application”
- “too strong for sensitive skin”
- “tingling sensation”
Firming effect Rarely Noted
- “Skin feels tighter”
- “improves elasticity”
- “plumper look”
- “smoother texture”
Availability issues Rarely Noted
- “Hard to find”
- “often out of stock”
- “discontinued in some stores”
- “confusing product name”
Strong fragrance Rarely Noted
- “Scent is overpowering”
- “too much perfume”
- “fragrance lingers”
- “smell is intense”
Sources: lovi.care, nordstrom.com, dermstore.com, bloomingdales.com, influenster.com, whatsinmyjar.com, and more
Questions and answers
Why is Natura Bissé C+C Vitamin Complex a weak match for sensitive skin?
Natura Bisse C+C Vitamin Complex is a weak match for sensitive skin because it lacks specific ingredients to target redness and irritation. A treatment for this skin needs soothing ingredients like niacinamide and snail secretion filtrate to calm redness while supporting skin health safely.
Scientific Reports, 2025Journal of Cosmetic Dermatology, 2021
Which ingredients make this serum a poor fit for sensitive skin?
This serum is a weak match for sensitive skin because its ingredients target general brightening rather than calming redness and irritation. To fit this skin type well, a treatment needs soothing components like niacinamide and snail secretion filtrate.
What does Vitamin C do for sensitive skin?
Vitamin C helps brighten skin, smooth out fine lines, and fade dark spots. Clinical studies show it is generally safe and well-tolerated when improving overall skin quality.
Journal of Cosmetic Dermatology, 2020Journal of Cosmetic Dermatology, 2023
What does Vitamin E do for sensitive skin?
Vitamin E helps calm sensitive skin by reducing redness, swelling, and irritation while strengthening the skin barrier against everyday environmental stress. Regular use is unlikely to cause trouble and may improve overall comfort.
Archives of Biochemistry and Biophysics, 1992Scanning Microscopy, 1993
Where does it go in a skincare routine for sensitive skin?
This treatment goes in the evening routine for sensitive skin, applied after the soothing toner and before the moisturizer. While this product is generally safe and unlikely to cause irritation, it is a weak match because it does not target redness and irritation, so sensitive skin needs calming ingredients like centella asiatica and soothing plant extracts.
Can I use this serum with retinol, and in what order?
You can use this treatment alongside retinol by applying the vitamin C serum in the morning and saving your retinol for your evening routine. This timing helps you get the antioxidant benefits of Ascorbic Acid and Vitamin E safely while keeping redness and irritation less likely.
How often should I use it?
This treatment is best used in the evening once a week for sensitive skin, and people who tolerate it well and see good results can carefully use it more often. Because this product is a weak match for sensitive skin, a treatment of this type needs soothing and calming ingredients like centella asiatica, green tea, or aloe vera to help manage redness and irritation.
Can this serum clog pores, cause breakouts or purging for sensitive skin?
This treatment is unlikely to clog pores or cause breakouts for sensitive skin because its ingredients have a safe profile without harsh elements, though a product of this type needs calming agents and soothing botanical extracts to properly comfort sensitive skin.
Is it fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum, limonene, and linalool).
What the research says
Co-encapsulation of alpha-tocopherol and alpha-tocopheryl acetate in nanostructured lipid carrier gel formulations significantly enhanced moisture retention up to 68% and improved skin elasticity in human volunteers compared to a solution gel.
Scientific Reports, 2025Transdermal emulgel preparations containing 5% ascorbic acid and sodium ascorbyl phosphate both effectively reduced wrinkle depth and enhanced skin elasticity in human volunteers with no statistically significant difference between them.
Journal of Cosmetic Dermatology, 2021Vitamin E in O/W and W/O emulsions significantly increased stratum corneum hydration and enhanced water-binding capacity, with an optimum concentration of 5%.
Arzneimittel-Forschung, 1998Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use.
Journal of Cosmetic Dermatology, 2022Topical treatments containing rosehip extract may reduce the size and erythema of postsurgical scars through macrophage polarization and inflammatory cytokine inhibition, though current clinical evidence remains insufficient to recommend its routine use.
Journal of Cosmetic Dermatology, 2024Sunflower and rosehip oil nanoemulsions prepared with a mix of phospholipids and synthetic emulsifiers permeated intact skin to the dermis and showed a more prominent healing effect in a human organotypic skin explant culture wound model compared to nanoemulsions prepared only with phospholipids.
Pharmaceutics, 2023A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro.
Pharmaceutics, 2023Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023
Why other serums fit sensitive skin better
Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.
European Journal of Pharmaceutics and Biopharmaceutics, 2016
Ingredients
Water, Sodium Ascorbyl Phosphate, Sodium Acrylates Copolymer, Propanediol, Glycerin, Hydrogenated Polyisobutene, Rosa Canina Oil Fruit, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Citric Acid, Tocopheryl Acetate, Anogeissus Leiocarpus Bark Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Hydrolyzed Collagen, Sodium Chondroitin Sulfate, Prunus Amygdalus Dulcis Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Polysorbate 60, Sorbitan Stearate, Disodium Edta, Tocopherol, Potassium Sorbate, Phenoxyethanol, Parfum, Limonene, Linalool, Citrus Nobilis Oil Mandarin Orange Oil, Citrus Aurantium Dulcis Oil, Amyl Cinnamal, Yellow 5 Ci 19140
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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