IOPE PDRN Caffeine Shot Serum for mature skin
Bio-Pdrn
Caffeine
Niacinamide
Adenosine
Lactobacillus Lysate FermentHigh
- SuperiorNormal Skin Fit
- HighEffectiveness
- HighSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your normal skin is provided by niacinamide and beta-glucan, which help repair the skin barrier and offer humectant benefits, while caffeine and niacinamide work to energize and improve skin tone.
- Adenosine and Acetyl Tetrapeptide-11 are included to effectively address your concerns about wrinkles and fine lines.
- The formulation is safe for your skin, as it contains no harsh or irritating ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.8Overall rating based on 1.5k+ reviewsBased on a very large amount of data, users consistently praise this serum for its lightweight, fast-absorbing texture and its ability to visibly reduce facial puffiness and refine skin texture. While highly effective for "de-puffing" and strengthening the moisture barrier, some users with very dry skin find it requires an additional moisturizer, and the high price point is a frequent point of contention.
Highlights
Lightweight texture Mostly Mentioned
- “absorbs like water”
- “zero stickiness”
- “sinks right in”
- “lightweight and refreshing”
Reduces puffiness Often Mentioned
- “swelling goes down quickly”
- “jawline looks tighter”
- “less puffiness in morning”
- “face looks more contoured”
Expensive product Often Mentioned
- “price gives me pause”
- “wish it were affordable”
- “rationing it due to cost”
- “price-to-amount ratio is steep”
Gentle on skin Sometimes Noted
- “no irritation on sensitive days”
- “works gently”
- “didn't experience blemishes”
- “soothing feel”
Improves skin barrier Sometimes Noted
- “skin barrier feels stronger”
- “pores look managed”
- “skin became smoother”
- “refined skin texture”
Dry skin needs more Sometimes Noted
- “not heavy-duty hydration”
- “need cream afterwards”
- “felt tightness after a few hours”
- “too light for winter”
Minor breakouts Rarely Noted
- “small breakouts on forehead”
- “tiny red bumps”
- “caused minor texture issues”
Subtle anti-aging Rarely Noted
- “haven't noticed major firmness changes”
- “results are preventative”
- “didn't see dramatic transformation”
Sources: lovi.care, oliveyoung.co.kr, sokoglam.com, hwahae.co.kr, reddit.com, yesstyle.com, and more
Questions and answers
What makes IOPE PDRN Caffeine Shot Serum a great fit for mature skin?
IOPE PDRN Caffeine Shot Serum is a great fit because adenosine and Acetyl Tetrapeptide-11 effectively target wrinkles and fine lines. In addition, niacinamide and beta-glucan help repair the skin barrier and keep skin hydrated, while caffeine and niacinamide work together to energize and improve skin tone.
International Journal of Cosmetic Science, 2018Scientific Reports, 2024
Which ingredients make this serum a good fit for mature skin?
Adenosine and Acetyl Tetrapeptide-11 are included to effectively address your concerns about wrinkles and fine lines, while niacinamide and beta-glucan help repair the skin barrier and offer moisture. In addition, caffeine and niacinamide work together to energize and improve your skin tone.
International Journal of Cosmetic Science, 2018Scientific Reports, 2024
What does Bio-PDRN do for mature skin?
Bio-PDRN helps mature skin by encouraging skin cell renewal, supporting collagen production, and improving firmness and texture. It is unlikely to cause irritation and may reduce the look of fine lines while boosting overall skin health.
What does Caffeine do for mature skin?
Caffeine helps protect mature skin against sun damage and early aging by acting as an antioxidant that fights off daily environmental stress. It may also boost blood flow and improve overall skin firmness over time.
Skin Pharmacology and Physiology, 2013Experimental Dermatology, 2024
Where does this serum go in a skincare routine for mature skin?
This treatment serum goes in your evening routine after cleansing and toning, and before moisturizing. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.
Can I use it with retinol, and in what order?
You can use this serum with retinol by applying the serum first to help repair the skin barrier and smooth fine lines, followed by your retinol. This combination is generally well tolerated, but if your skin is sensitive, you may want to alternate nights to avoid irritation.
Scientific Reports, 2024International Journal of Cosmetic Science, 2018
How often should I use this serum?
This serum is used in the evening as part of your routine for mature skin. It may be used once a day, and some versions of this type of treatment can also be used twice a day if your skin tolerates it well.
Can it clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin since it contains no harsh or irritating ingredients. It is generally safe, though minor breakouts are possible for some people.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy.
Journal of Cosmetic Dermatology, 2021Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.
International Journal of Cosmetic Science, 2018Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events.
Journal of Cosmetic Dermatology, 2019Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.
International Journal of Molecular Sciences, 2025Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.
Molecular Medicine Reports, 2023A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.
Molecules, 2022A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.
International Journal of Cosmetic Science, 2011Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.
Frontiers in Physiology, 2019Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.
AAPS PharmSciTech, 2021Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects.
Journal of Cosmetic Dermatology, 2022Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.
International Journal of Medical Sciences, 2021Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials.
Current Issues in Molecular Biology, 2022
Ingredients
Lactobacillus Lysate Ferment, Water, Propanediol, Glycerin, Niacinamide, Butylene Glycol, Caffeine, Dipropylene Glycol, 2-Hexanediol, Diethoxyethyl Succinate, Glyceryl Polymethacrylate, Polyacrylate Crosspolymer-6, Mannitol, Ethylhexylglycerin, Adenosine, Sodium Citrate, Dextrin, Theobroma Cacao Extract, Citric Acid, Disodium Edta, T-Butyl Alcohol, Arginine, Cyclodextrin, Hydroxypropyl Cyclodextrin, Maltodextrin, Xanthan Gum, Beta-Glucan, Acetyl Tetrapeptide-11, Tocopherol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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