Bioderma Hydrabio Serum for mature skin
Aquagenium Patent
Sodium Hyaluronate
Niacinamide
Glycerin
Laminaria Ochroleuca Extract
Average
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for mature skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate moisturizing for your normal skin due to glycerin and sodium hyaluronate, which hydrate and plump effectively.
- While beneficial for general skincare, these ingredients are not specifically targeted to address your concerns with wrinkles and fine lines.
- The product is safe for your normal skin, with no risks of irritation from harsh ingredients.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
People Say
★4.7Overall rating based on 3.4k+ reviewsBased on a very large amount of data, users consistently praise this serum for its lightweight, gel-like texture that delivers deep hydration without leaving a sticky residue, making it ideal for dehydrated and sensitive skin. While most find it plumps and smooths the complexion effectively, those with extremely dry skin often note it works best when layered under a richer moisturizer rather than as a standalone solution.
Highlights
Lightweight & fast-absorbing Mostly Mentioned
- “absorbs instantly”
- “weightless feel”
- “no sticky residue”
- “sinks right in”
Deep hydration Often Mentioned
- “plumps fine lines”
- “skin feels bouncy”
- “instant moisture boost”
- “glowy complexion”
Excellent makeup base Sometimes Noted
- “foundation sits perfectly”
- “no pilling under makeup”
- “smooths texture”
- “great primer”
Sensitive skin friendly Sometimes Noted
- “no stinging”
- “calms redness”
- “didn't break me out”
Fragrance presence Sometimes Noted
- “scent is too strong”
- “wish it was fragrance-free”
- “smells like perfume”
- “irritated my nose”
Price vs. size Sometimes Noted
- “finished too quickly”
- “expensive for the amount”
- “wish bottle was bigger”
- “pricey per ounce”
Availability issues Rarely Noted
- “hard to find in stock”
- “sold out often”
- “had to order online”
- “not in US drugstores”
Not enough for dry skin Rarely Noted
- “need a cream on top”
- “too light for winter”
- “skin still felt dry later”
- “needs layering”
Sources: lovi.care, dermstore.com, lookfantastic.com, boots.com, influenster.com, makeupalley.com, and more
Questions and answers
How well does Bioderma Hydrabio Serum work for mature skin?
Bioderma Hydrabio Serum works moderately well for mature skin, offering basic hydration through glycerin and sodium hyaluronate while being very safe and gentle, though it lacks specific ingredients to target wrinkles and fine lines. A product of this type for mature skin needs potent anti-aging ingredients, peptides, antioxidants, and rich nourishing components to effectively smooth lines and maintain a healthy moisture balance.
Which ingredients make this serum a good fit for mature skin?
Glycerin and sodium hyaluronate make this serum a good fit by hydrating and plumping mature skin. To best fit mature skin, this type of product also needs potent anti-aging ingredients like peptides and antioxidants to smooth wrinkles and fine lines.
What does Aquagenium Patent do for mature skin?
Aquagenium Patent helps mature skin by targeting hydration and improving water retention to keep the skin feeling soft and smooth. Because it supports the skin's natural moisture balance, it is unlikely to cause irritation and may help reduce the look of fine lines over time. This type of skin needs ingredients that enhance moisture-binding proteins and antioxidants to stay firm and plump.
What does Hyaluronic Acid do for mature skin?
Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Journal of Drugs in Dermatology, 2011Skin Research and Technology, 2024
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and adds extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first to hydrate your skin, followed by your retinol product. This helps keep your skin comfortable, though mature skin addressing wrinkles and fine lines also needs ingredients like peptides, retinoids, or antioxidants for better anti-aging results.
How often should I use this serum?
You can use this treatment in the evening as part of your routine. Daily application helps keep your skin hydrated and is unlikely to cause irritation.
Health Science Reports, 2021Journal of Cosmetic Dermatology, 2020
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin. It has a safe profile with no harsh ingredients that typically cause irritation.
Can I use this serum around the eyes or on my body?
You can safely use this moisturizing treatment around the eyes and on the body because it is gentle and free of harsh ingredients, though its hydration benefits are better suited for general use rather than firming or smoothing fine lines.
Is this serum fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.
Antioxidants, 2021Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012
Why other moisturizers fit mature skin better
Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.
International Journal of Medical Sciences, 2021Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement.
Nanomaterials, 2024Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.
Journal of Cosmetic Dermatology, 2026
Ingredients
Water, Glycerin, Xylitol, Sodium Polyacrylate, Mannitol, Rhamnose, Fructooligosaccharides, Laminaria Ochroleuca Extract, Niacinamide, Pyrus Malus Fruit Extract, Dimethicone, Cyclopentasiloxane, Trideceth-6, Peg Ppg-18 18 Dimethicone, Sodium Hyaluronate, Hexyldecanol, Caprylic Capric Triglyceride, Disodium Edta, Chlorphenesin, Phenoxyethanol, Parfum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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