AXIS-Y Spot The Difference Blemish Treatment for oily acne-prone skin
Niacinamide
Salicylic Acid Bha
Glycolic Acid Aha
4-Terpineol
Ceramide NpHigh
- HighOily Skin Fit
- HighEffectiveness
- HighSafety
A great choice for oily acne-prone skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your oily skin, this treatment effectively addresses blemishes and breakouts with salicylic acid and glycolic acid, which decongest pores and offer moderate exfoliation. Niacinamide further aids in regulating oil production and reducing inflammation, complementing the actions of Centella Asiatica Extract and Beta-Glucan.
- The formula includes beneficial ingredients like rosemary oil and tea tree leaf extract, which provide additional anti-inflammatory and antimicrobial support for acne-prone skin.
- This product is safe for your skin, as it contains soothing agents and avoids harsh or irritating components.
How to apply
- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
People Say
★4.6Overall rating based on 800+ reviewsUsers with acne-prone, oily, and sensitive skin praise this lightweight gel for effectively reducing redness and calming active breakouts without drying out the skin. While many experience fast results and appreciate the hydrating ceramide capsules, some find the bottle size too small and note that it may take time to see significant changes on stubborn blemishes.
Highlights
Gentle & non-drying Mostly Mentioned
- “hydrating ceramide capsules”
- “doesn't dry skin”
- “soothing sensation”
- “no irritation”
Effective acne relief Often Mentioned
- “reduces pimple size”
- “calms active breakouts”
- “flattens bumps”
- “clears blemishes overnight”
Lightweight texture Often Mentioned
- “absorbs quickly”
- “non-sticky gel”
- “layers well”
- “lightweight formula”
Small product size Often Mentioned
- “tiny bottle”
- “finished quickly”
- “wish it was bigger”
- “small quantity”
Good for sensitive skin Sometimes Noted
- “no irritation”
- “gentle formula”
- “suitable for sensitive skin”
- “calms redness”
Slow results Sometimes Noted
- “not an overnight fix”
- “took a few days”
- “didn't see difference”
- “slow progress”
Absorption issues Rarely Noted
- “takes time to absorb”
- “leaves wet layer”
- “sticky if overapplied”
- “capsules take time to melt”
Scent/applicator Rarely Noted
- “mild tea tree scent”
- “dropper is small”
- “hard to dispense”
- “herbal smell”
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Questions and answers
What makes AXIS-Y Spot The Difference Blemish Treatment a great fit for oily acne-prone skin?
This treatment is a great fit because it uses salicylic acid and glycolic acid to clear out pores and gently exfoliate oily skin. Niacinamide helps balance oil and calm redness, while tea tree leaf extract and soothing plant extracts provide extra support for acne-prone skin.
Indian Journal of Dermatology, Venereology and Leprology, 2007Archives of Dermatological Research, 2022
Which ingredients make this treatment a good fit for oily acne-prone skin?
Salicylic acid and glycolic acid help clear out clogged pores and gently exfoliate oily skin. Niacinamide helps control oil and calm redness, while tea tree leaf extract and Centella Asiatica extract provide extra soothing and antimicrobial support for breakouts.
Indian Journal of Dermatology, Venereology and Leprology, 2007Indian Journal of Pharmaceutical Sciences, 2016
What does Niacinamide do for oily acne-prone skin?
Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Journal of Cosmetic and Laser Therapy, 2006Journal of Cosmetic Dermatology, 2024
What does Salicylic Acid do for oily acne-prone skin?
Salicylic acid helps clear breakouts and keeps oily skin balanced by reducing oil levels and calming inflammation. It is well suited for oily, acne-prone skin because it targets pimples while helping keep the skin hydrated and protected.
Journal of Cosmetic Dermatology, 2025Experimental Dermatology, 2019
Where does this treatment go in a skincare routine for oily acne-prone skin?
This treatment goes in your evening routine, applied after cleansing and before moisturizing. While it is placed in the evening for simplicity and extra safety around sun exposure, some treatments can also be used in the morning or twice a day.
Can I use this treatment with retinol, and in what order?
You can use this treatment alongside retinol, but applying them in the same routine may be too harsh for your skin, so alternate nights or use one in the morning and the other at night. This helps prevent excessive irritation while still targeting breakouts effectively.
How often should I use this treatment?
Use this treatment in the evening as part of your routine. Start by using it once a week, and if your oily skin handles it well, you can carefully use it more often.
Indian Journal of Dermatology, Venereology and Leprology, 2007Archives of Dermatological Research, 2022
Can this treatment clog pores, cause breakouts or purging for oily acne-prone skin?
This treatment is a great fit for your oily acne-prone skin because it uses salicylic acid and glycolic acid to clear out pores and manage breakouts without clogging them. It helps calm angry skin and is unlikely to cause irritation.
Is this treatment fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.
Indian Journal of Pharmaceutical Sciences, 2016A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase.
BioMed Research International, 2020Topical 5% tea tree oil gel significantly improved total acne lesions and acne severity index compared to placebo in 60 patients with mild to moderate acne vulgaris, showing 3.55 times and 5.75 times greater efficacy respectively.
Indian Journal of Dermatology, Venereology and Leprology, 2007Tea tree oil nanoemulsion containing adapalene gel demonstrated significantly greater reductions in total, inflammatory, and non-inflammatory acne lesions as well as acne severity index compared to adapalene marketed gel in 100 patients with acne vulgaris over 12 weeks.
Archives of Dermatological Research, 2022Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients.
CMAJ, 2010Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy.
Journal of Cosmetic Dermatology, 2024Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients.
Journal of the American Academy of Dermatology, 2010Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks.
International Journal of Dermatology, 2000Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone.
Dermatologic Surgery, 2017A foam formulation of 2% 4-terpineol killed common ocular microorganisms within 60 seconds and at 14 and 28 days without causing skin or ocular irritation in human subjects.
BMJ Open Ophthalmology, 2018Topical tea tree oil and terpinen-4-ol produce good clinical outcomes in the management of Demodex blepharitis.
Cornea, 2022Topical treatment with Australian tea tree oil and terpinen-4-ol effectively moderates human demodicosis by lowering mite counts, relieving symptoms, and modulating the inflammatory immune response.
Parasitology, 2018
Ingredients
Water, Glycerin, Propanediol, 1,2-Hexanediol, Glycereth-26, Niacinamide, Caprylic Capric Triglyceride, Aloe Barbadensis Leaf Extract, Althaea Rosea Flower Extract, Laminaria Japonica Extract, Eclipta Prostrata Leaf Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Camellia Sinensis Leaf Extract, Monarda Didyma Leaf Extract, Hydrangea Macrophylla Leaf Extract, Mentha Aquatica Extract, Sasa Quelpaertensis Extract, Melaleuca Alternifolia Tree Leaf Extract, Melia Azadirachta Leaf Extract, Eclipta Prostrata Extract, Camphor Leaf Extract, Cryptomeria Japonica Leaf Extract, Pinus Pinaster Bud Extract Bark, Rosmarinus Officinalis Oil Leaf Rosemary Oil Leaf, Hydrogenated Lecithin, Chamaecyparis Obtusa Water, Trehalose, Octyldodeceth-16, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, C12-14 Pareth-12, Butylene Glycol, Xanthan Gum, Disodium Edta, Ceramide Np, Fructooligosaccharides, Beta-Glucan, Hydrolyzed Hyaluronic Acid, 4-Terpineol, Glycyrrhiza Glabra Root Rhizome Licorice Root Rhizome, Moringa Oleifera Seed Oil, Glycolic Acid, Salicylic Acid, Ethylhexylglycerin
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Specialist dermatologist, MBBS, MD, IFAAD
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Elina Nazarenko, MD
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Dermatology and diagnostic consultant
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Victoria Derkova, MS
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Cosmetic chemist, cosmetic development technologist
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