AXIS-Y Complete No-Stress Physical Sunscreen for oily skin

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Questions and answers

What the research says

• Microfine titanium dioxide does not penetrate human skin when formulated in an oil-in-water emulsion with the pigment dispersed in the aqueous phase, compared to oily dispersions and liposomal encapsulation which allow deeper skin penetration.

  International Journal of Cosmetic Science, 2000

• Topical application of micronised titanium dioxide results in no dermal absorption, with the particles being deposited solely on the outermost surface of the stratum corneum.

  Skin Pharmacology and Applied Skin Physiology, 2001

• Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles selectively inhibited C. acnes, outperformed erythromycin in preclinical acne models, and safely reduced acne lesions and redness in a clinical trial.

  Journal of Controlled Release, 2025

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Topical application of Calendula officinalis extract cream significantly improved skin hydration and firmness (reflected in significant changes in R0 and R6 parameters) in 21 healthy human volunteers compared to a base cream.

  Acta Poloniae Pharmaceutica, 2011

• Treatment with standardized extract of Calendula officinalis L. led to a shorter epithelization time and faster healing speed compared to mineral oil in patients with acute skin loss wounds of the hand and fingers healing by secondary intention.

  Tissue Barriers, 2022

• Topical administration of Calendula provides weak evidence of effectiveness in acute and chronic wounds compared to standard treatments based on a narrative review of available trials.

  Wounds, 2008

• Artemisia princeps-derived nanovesicles accelerate cell proliferation, decrease senescence-associated beta-galactosidase activity, inhibit MMP-1 activity more effectively than EGCG, and increase procollagen type I expression in human dermal cells and skin models.

  Journal of Extracellular Biology, 2025

• Artemisia annua aqueous extract increased the itching threshold, inhibited TSLP expression, and promoted FLG mRNA expression in in vitro and in vivo models.

  Journal of Ethnopharmacology, 2024

• Artemisia Capillaris Thunb. extract protects human HaCaT keratinocytes from UVB-induced apoptosis and inflammation by suppressing the cGAS/STING signaling pathway.

  Journal of Photochemistry and Photobiology. B, Biology, 2024

Ingredients

Water, Zinc Oxide, Propylyheptyl Caprylate, Butyloctyl Salicylate, Propanediol, Titanium Dioxide, Butylene Glycol Dicaprylate Dicaprate, Dicaprylyl Ether, Caprylyl Methicone, Polyglyceryl-4 Diisostearate Polyhydroxystearate Sebacate, Disiloxane, Niacinamide, Trimethylsiloxysilicate, Calendula Officinalis Flower Extract, Camellia Sinensis Leaf Extract, Artemisia Capillaris Flower Extract, Vitis Vinifera Seed Extract Grape Seed Extract, Juniperus Virginiana Oil, Cedrus Atlantica Oil Bark, Amyris Balsamifera Oil Bark, Pogostemon Cablin Oil, Chamomilla Recutita Flower Water Matricaria Flower Water, Disteardimonium Hectorite, Magnesium Sulfate, Stearic Acid, Aluminum Hydroxide, Triethoxycaprylylsilane, Methyl Methacrylate Crosspolymer, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, 1,2-Hexanediol, Vinyl Dimethicone Methicone Silsesquioxane Crosspolymer, Polymethylsilsesquioxane, Glyceryl Caprylate, Caprylyl Glycol, Ethylhexylglycerin, Adenosine, Copaifera Officinalis Resin, Tocopherol, Squalane, Allantoin, Glycerin, Palmitoyl Tripeptide-5

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.