VT Cosmetics PDRN Essence 100 for oily skin
Pdrn Polydeoxyribonucleotide
Sodium Hyaluronate
Niacinamide
AdenosineAverage
- HighOily Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for oily skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your oily skin, with niacinamide helping to regulate sebum and sodium hyaluronate providing hydration, though it does not directly address concerns about oily shine.
- The inclusion of PDRN and panthenol supports skin regeneration and barrier resilience, which are generally beneficial for maintaining healthy skin.
- The product is safe for your oily skin, as it contains soothing ingredients like sodium hyaluronate and glycerin and lacks harsh or prohibited substances.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
People Say
★4.8Overall rating based on 1.6k+ reviewsBased on a very large amount of data, users with dry, sensitive, and combination skin highly praise this essence for its ability to deliver a glass skin finish and deep hydration without irritation. It is widely celebrated for restoring compromised barriers and plumping fine lines. A minority of users with oily skin find the texture too heavy or tacky.
Highlights
Hydration and glow Mostly Mentioned
- “Instant glass skin”
- “deeply moisturizing”
- “plumps fine lines”
- “radiant finish”
Soothing and repair Often Mentioned
- “Calms redness”
- “heals breakouts”
- “strengthens barrier”
- “non-irritating”
Fragrance-free Sometimes Noted
- “No scent”
- “great for sensitive noses”
- “unscented”
- “no artificial fragrance”
Good texture Sometimes Noted
- “Milky consistency”
- “absorbs quickly”
- “lightweight feel”
- “layers well”
Sticky finish Sometimes Noted
- “Feels sticky”
- “tacky residue”
- “hair sticks to face”
- “takes time to dry”
Nice packaging Rarely Noted
- “Airless pump”
- “hygienic design”
- “easy to dispense”
- “cute bottle”
Caused breakouts Rarely Noted
- “Caused whiteheads”
- “clogged pores”
- “broke me out”
- “small bumps”
Expensive price Rarely Noted
- “A bit pricey”
- “expensive for size”
- “waited for sale”
- “costly”
Pump design Rarely Noted
- “Pump drips”
- “messy dispenser”
- “squirts everywhere”
- “hard to control”
Texture issues Rarely Noted
- “Too thick”
- “hard to spread”
- “heavy for oily skin”
- “feels gloopy”
Sources: lovi.care, oliveyoung.com, stylekorean.com, skinsort.com, reddit.com, yesstyle.com, and more
Questions and answers
How well does VT PDRN Essence 100 work for oily skin?
This essence works well enough for oily skin by offering moderate hydration and barrier support, though it does not directly target oily shine. To best manage oily skin, a treatment of this type needs ingredients like niacinamide and zinc PCA to control excess oil and large pores while keeping the skin balanced.
American Journal of Clinical Dermatology, 2002The Journal of Dermatological Treatment, 2017
Which ingredients make this treatment a good fit for oily skin?
Niacinamide helps regulate sebum, while sodium hyaluronate and glycerin provide comfortable hydration for your oily skin. Treatments of this type that fit oily skin best need ingredients like zinc pca and ferulic acid to manage oily shine and enlarged pores.
What does PDRN do for oily skin?
PDRN helps calm and repair oily skin by supporting skin cell growth and collagen production. This ingredient is unlikely to clog pores while working to improve the overall texture and healing of your skin.
What does Hyaluronic Acid do for oily skin?
Hyaluronic acid helps oily skin by reducing extra oil and sebum production without causing irritation. Clinical studies show it successfully balances oil levels while keeping the skin comfortable.
Where does this treatment go in a skincare routine for oily skin?
This treatment goes in the evening routine for your oily skin, applied after cleansing and before moisturizing. Oily skin works best with products that provide lightweight hydration and help control shine.
Can I use this treatment with retinol, and in what order?
You can use this treatment with retinol, applying the treatment before your moisturizer in your evening routine. This product is unlikely to cause irritation on oily skin, but an oily skin routine also needs lightweight, oil-balancing ingredients like niacinamide to help manage shine.
How often should I use this treatment?
You can use this treatment in your evening routine. Oily skin works best with products that help control extra oil while keeping the skin hydrated.
Can this treatment clog pores, cause breakouts or purging for oily skin?
This treatment is unlikely to cause breakouts for oily skin, as it contains soothing ingredients like sodium hyaluronate and glycerin without harsh substances, though reviews show a low chance of causing breakouts and a moderate chance of a sticky finish. Oily skin prone to clogged pores needs lightweight, oil-free hydration and pore-clearing ingredients like salicylic acid to keep skin clear.
Is this treatment fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.
Journal of Cosmetic Dermatology, 2025A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects.
International Journal of Molecular Sciences, 2025Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes.
Molecular Medicine Reports, 2023A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model.
Molecules, 2022Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021
Why other serums fit oily skin better
Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Allantoin, Adenosine, Betaine, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Triethanolamine
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.