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Soolantra Cream for sensitive skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Soolantra Cream

High

  • HighNormal Skin Fit
  • HighEffectiveness
  • HighSafety

A great choice for sensitive skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Highly suitable for your normal skin, this cream effectively addresses redness and irritation with ivermectin, which targets inflammation, while glycerin and dimethicone maintain skin hydration and smoothness.
  • The formulation is designed to be gentle, ensuring no risks of irritation for your sensitive skin due to the absence of harsh ingredients.
  • This product offers excellent treatment for reducing acne lesions and blemishes.

How to apply

  • Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
  • Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
  • Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
  • Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
  • Always do a patch test before your first use and avoid getting the serum too close to your eyes .

People Say

★4.1Overall rating based on 500+ reviews

A notable portion of users experience an initial worsening of their skin, including breakouts and irritation, during the first few weeks of use before seeing improvements, indicating a need for patience.

Highlights

  • Clears pustules Mostly Mentioned
    • “Cleared all lumps and bumps”
    • “Pustules diminishing after 3 weeks”
    • “Acne-type bumps completely gone”
    • “No new pustules formed”
  • Life-changing results Often Mentioned
    • “Regained my self-confidence”
    • “Best thing I have ever tried”
    • “Miracle cream for my face”
    • “Wish I found this years ago”
  • Reduces redness Often Mentioned
    • “Calming redness significantly”
    • “Redness reduced by 90%”
    • “Skin tone is finally even”
    • “Helps with persistent flushing”
  • Initial flare-up Often Mentioned
    • “Got worse before getting better”
    • “Terrible breakout in first week”
    • “Face erupted with whiteheads initially”
    • “Skin looked awful for two weeks”
  • Improves texture Sometimes Noted
    • “Skin feels baby soft”
    • “Smoother than it has ever been”
    • “Eliminated scabby, peeling skin”
    • “Rough patches smoothed out”
  • High cost Sometimes Noted
    • “Very expensive without insurance”
    • “Price is too high”
    • “Insurance declined coverage”
    • “Cost is a major downside”
  • Slow onset Sometimes Noted
    • “Took 3 months to see results”
    • “Requires patience, not overnight”
    • “Slow process to clear skin”
    • “Didn't work until week 12”
  • Burning or itching Rarely Noted
    • “Mild burning upon application”
    • “Skin felt itchy and irritated”
    • “Stinging sensation for first few days”
    • “Face hurt when touched”

Sources: lovi.care, drugs.com, webmd.com, theindependentpharmacy.co.uk, doctorfox.co.uk, and more

Questions and answers

What makes Soolantra Cream a great fit for sensitive skin?

Soolantra Cream is a great fit for sensitive skin because it is a gentle treatment that effectively calms redness and irritation using ivermectin, while glycerin and dimethicone keep the skin hydrated and smooth. The formulation is carefully designed without harsh ingredients, meaning it is unlikely to cause irritation on your sensitive skin.

Gels, 2023

Which ingredients make this cream a good fit for sensitive skin?

This cream is a great fit for sensitive skin because it uses ivermectin to calm redness and irritation while glycerin and dimethicone keep your skin smooth and hydrated. The gentle formula avoids harsh ingredients, so it is unlikely to cause irritation.

Gels, 2023

What does Glycerin do for sensitive skin?

Glycerin helps keep sensitive skin soft and deeply hydrated while supporting the skin barrier. It is unlikely to cause irritation and may protect against dryness and roughness.

The British Journal of Dermatology, 2008Acta Dermato-venereologica, 1999

Where does this cream go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your cleansing and toning steps, and before your moisturizer. Putting it in the evening helps keep your routine simple and adds extra safety around sun exposure.

Can I use this cream with retinol, and in what order?

You can use this cream with retinol, but it is best to apply retinol and this treatment on alternating nights or space them out to keep your sensitive skin calm and smooth.

How often should I use this cream?

You should use this cream in the evening as part of your routine. It is a great fit for your sensitive skin because it calms redness and irritation while keeping your face soft and smooth without harsh ingredients.

Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to clog pores or cause breakouts for your sensitive skin because it is designed to be gentle without harsh ingredients. However, you may experience an initial flare-up when you first start using it.

Gels, 2023

Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol, stearyl alcohol, and oleyl alcohol are fatty alcohols, which soften the skin.

What the research says

  • Pranoprofen-loaded nanostructured lipid carriers dispersed in Carbomer 940 and Sepigel 305 gels provided sustained drug release and demonstrated anti-inflammatory efficacy in animal models without causing skin irritation or altering biophysical properties in humans.

    Gels, 2023

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups.

    Military Medicine, 2024

  • A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate.

    Skin Research and Technology, 2000

  • Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms.

    Clinical and Experimental Dermatology, 2007

  • Topical chloramphenicol-betamethasone combined with sodium hyaluronate/trehalose/carbomer gel compared to chloramphenicol-betamethasone alone reduced most subjective symptoms at 1 week but increased blurred vision at 4 weeks following strabismus surgery in 31 patients, with no significant differences in conjunctival inflammation between treatments.

    Journal of Ocular Pharmacology and Therapeutics, 2019

  • Incorporating nanoemulsions into hydrogels with increasing Carbopol 934 proportions from 1% to 3% progressively decreased the percutaneous flux rates of terbinafine and citral, increased drug accumulation in the stratum corneum while decreasing it in the epidermis/dermis compared to nanoemulsions alone, and shifted delivery routes from skin appendages to intercellular paths.

    International Journal of Nanomedicine, 2016

  • Topical liquiritin carbomer gel treatment restored skin barrier function, increased barrier proteins and antioxidant enzymes, and decreased inflammatory cytokines and oxidative stress in a mouse model of glucocorticoid-induced skin inflammation.

    Pharmaceutics, 2024

  • A soap-free cleansing lotion containing cetyl alcohol and sodium cocoyl apple amino acids reduced skin surface impurities and improved skin hydration, barrier function, and skin tone in 27 healthy adult subjects over 30 days.

    Cureus, 2025

Ingredients

Ivermectin, Glycerin, Isopropyl Palmitate, Carbomer, Dimethicone, Disodium Edta, Citric Acid, Cetyl Alcohol, Stearyl Alcohol, Sorbitan Stearate, Methyl Parahydroxybenzoate, Propyl Parahydroxybenzoate, Phenoxyethanol, Propylene Glycol, Oleyl Alcohol, Sodium Hydroxide, Water

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

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QR code: get the Lovi app
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