SkinMedica TNS Advanced+ Serum for dry skin
Human Fibroblast Conditioned Media
Collagen Peptides
Trifluoroacetyl Tripeptide-2
Glycerin
Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract
High
- HighDry Skin Fit
- AverageEffectiveness
- HighSafety
A great choice for dry skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your dry skin due to the presence of Shea Ethyl Esters Butter and Glycerin, which provide emollient and humectant actions respectively, addressing dryness and flakiness.
- The serum offers excellent skin rejuvenation with Human Fibroblast Conditioned Media and Trifluoroacetyl Tripeptide-2, improving skin texture and reducing fine lines, while Lactococcus Lysate Ferment and Whey Protein further support skin health.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of prohibited or harsh ingredients.
How to apply
- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.5Overall rating based on 5.2k+ reviewsBased on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.
Highlights
Improves fine lines Mostly Mentioned
- “can make the world of difference in your fine lines and wrinkles”
- “deeper lines around my mouth lessened significantly”
- “notice an improvement in fines lines”
- “creases in my forehead became more shallow”
Very expensive price Mostly Mentioned
- “The price tag is steep”
- “Expensive but fast results!”
- “The price is ridiculous”
- “A lot of money for a flawed product”
Firms sagging skin Often Mentioned
- “my skin had much more elasticity”
- “feels firmer, stays well hydrated”
- “preventing/restoring sagging skin”
- “plumps and firms with zero irritation”
Smoothes skin texture Often Mentioned
- “My skin looks smoother”
- “enhanced skin texture and tone”
- “overall glow to my skin”
- “visibly softer skin and improved texture”
Faulty pump dispenser Often Mentioned
- “One of the pumps failed on me”
- “The pumps did not work properly”
- “faulty pump & other issues”
- “dual pump failure issue”
Safe for sensitive skin Sometimes Noted
- “anti aging treatment that works for sensitive skin”
- “enhanced my skin without causing irritation”
- “plumps and firms with zero irritation”
- “Safe for sensitive skin”
Uneven product dispensing Sometimes Noted
- “serum ran out before the cream that you mix it with”
- “never know whether I'm getting enough from each side”
- “only have the clear serum but not the white one coming out”
- “They didn't dispense evenly”
Sources: lovi.care, dermapproved.com, lovelyskin.com, ellemesmedspa.com, walmart.com, theskinspot.com, and more
Questions and answers
What makes SkinMedica TNS Advanced+ Serum a great fit for dry skin?
SkinMedica TNS Advanced+ Serum is a great fit for dry skin because it contains shea ethyl esters butter and glycerin, which help smooth away dryness and flakiness. It also features human fibroblast conditioned media and peptides to rejuvenate skin texture and reduce fine lines without any risk of irritation.
Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Surgery, 2024
Which ingredients make this serum a good fit for dry skin?
This serum is a great fit for dry skin thanks to shea ethyl esters butter and glycerin, which soften dry patches and hold moisture in the skin. It is very unlikely to cause irritation and helps improve skin texture.
What does Human Fibroblast Conditioned Media do for dry skin?
Human Fibroblast Conditioned Media helps reduce signs of aging and supports skin recovery. For dry skin, this type of product needs added hydrating ingredients and rich emollients to keep the skin soft and smooth.
Dermatologic Surgery, 2024Photodermatology, Photoimmunology & Photomedicine, 2016
What do Collagen Peptides do for dry skin?
Collagen peptides help improve dry skin by boosting hydration and keeping skin soft and smooth over time. Taking them daily helps lock in moisture and supports your skin barrier so it holds onto water better.
Where does this serum go in a skincare routine for dry skin?
This serum goes in your evening routine after cleansing and before moisturizing, following Lovi routines for simpler application and extra safety around sun exposure. It is unlikely to irritate dry skin because it lacks harsh ingredients.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first in your evening routine, letting it absorb before you put on your retinol. This approach helps nourish your dry skin while keeping the risk of irritation low because the formula is gentle.
How often should I use this serum?
SkinMedica TNS Advanced+ Serum is a great fit for your dry skin and is best used in the evening as part of your routine. Glycerin and shea ethyl esters butter help address dryness and flakiness while keeping the skin safe from irritation.
Can this serum clog pores, cause breakouts or purging for dry skin?
This serum is a great fit and is unlikely to cause breakouts or clog pores on dry skin because it is free of harsh or heavy ingredients that typically block pores. Its gentle formula hydrates and smooths your skin safely without irritation.
Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Surgery, 2024
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of human fibroblast conditioned media and its derived growth factors and exosomes significantly reduces signs of skin aging and stimulates skin recovery and quality after in-office cosmetic procedures.
Dermatologic Surgery, 2024A porous functionally graded scaffold based on κ-carrageenan, arginine, and whey protein isolate was designed and developed for the management of chronic skin wounds, with cell migration, adhesion, and proliferation evaluated in vitro on fibroblasts and wound healing potential studied in vivo on a murine model.
International Journal of Pharmaceutics, 2024A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic.
Journal of Cosmetic Dermatology, 2021Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls.
Frontiers in Medicine, 2024Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls.
Journal of Agricultural and Food Chemistry, 2020The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012
Ingredients
Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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