Perricone MD Deep Crease Serum for oily skin
Acyl-Glutathione- S-Palmitoylglutathione
Tetrahexyldecyl Ascorbate
Palmitoyl Tripeptide-5
Acetyl Hexapeptide-8
Average
- AverageOily Skin Fit
- AverageEffectiveness
- HighSafety
Works for oily skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for oily skin as Squalane and Macadamia Ternifolia Seed Oil provide emollient action, but it lacks sufficient ingredients for optimal oil control to address your oily shine.
- The presence of Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8 offers excellent wrinkle reduction for treating fine lines and wrinkles, which is a supportive benefit for your skin.
- The safety profile is good, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
People Say
★4.5Overall rating based on 800+ reviewsUsers in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.
Highlights
Lightweight texture Mostly Mentioned
- “Absorbs quickly”
- “not sticky or greasy”
- “feels silky and smooth”
Hydrating formula Often Mentioned
- “Skin drinks it up”
- “leaves skin feeling plump”
- “adds a boost of moisture”
Softens deep lines Often Mentioned
- “Deeper lines look softer”
- “smile lines appear less pronounced”
- “frown lines look less visible”
High price point Often Mentioned
- “Price is quite premium”
- “barrier for some”
- “expensive investment”
Improves firmness Sometimes Noted
- “Skin feeling firmer”
- “noticeable improvement in bounce”
- “more lifted look”
Dropper issues Sometimes Noted
- “Difficult to pick up product”
- “dropper doesn't work well”
- “inconsistent dispensing”
Gradual results Sometimes Noted
- “Not an overnight miracle”
- “results are subtle”
- “haven't seen 11s improve yet”
Fragrance sensitivity Rarely Noted
- “Rose scent may not be ideal”
- “not for those with fragrance allergies”
Sources: lovi.care, perriconemd.com, dermstore.com, ulta.com, youtube.com, reddit.com, and more
Questions and answers
How well does Perricone MD Deep Crease Serum work for oily skin?
Perricone MD Deep Crease Serum offers moderate suitability for your oily skin because while it helps smooth out fine lines and wrinkles, it lacks enough ingredients to control oily shine. To work best for oily skin, a treatment of this type needs effective ingredients like niacinamide to manage excess oil and reduce enlarged pores while keeping the skin comfortable.
American Journal of Clinical Dermatology, 2013Annals of Dermatology, 2019
Which ingredients make this serum a good fit for oily skin?
Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8 make this serum a good fit for oily skin by helping reduce fine lines and wrinkles. Because this product offers only a moderate fit for oily skin, a product of this type needs ingredients like niacinamide, ferulic acid, and zinc PCA to control excess oil and manage shine.
American Journal of Clinical Dermatology, 2013Annals of Dermatology, 2019
What does Acyl-Glutathione do for oily skin?
Acyl-Glutathione is unlikely to be the best fit for oily skin, as this skin type needs balancing ingredients and lightweight hydrators to control shine and keep pores clear without feeling heavy.
What does Palmitoyl Glutathione do for oily skin?
Palmitoyl glutathione helps keep oily skin looking smooth and clear while improving its overall moisture. This ingredient is unlikely to cause irritation and may support a balanced, healthy complexion.
Where does this serum go in a skincare routine for oily skin?
This treatment goes in the evening routine after cleansing and before moisturizing, for simplicity and extra safety around sun exposure. It works for oily skin, though this skin type needs oil-control ingredients to better manage oily shine.
Can I use this serum with retinol, and in what order?
You can use this treatment with retinol by applying your retinol first and following it with this serum, or by using retinol at night and this serum in the morning. This routine helps you smooth fine lines while minimizing the likelihood of skin discomfort. To best suit oily skin, this type of product also needs ingredients that control oil and reduce shine.
American Journal of Clinical Dermatology, 2013Annals of Dermatology, 2019
How often should I use this serum?
You can use this treatment in the evening as part of your nightly routine. This product offers moderate suitability for oily skin, but to properly manage oily shine, this skin type needs oil-controlling ingredients.
Can this serum clog pores, cause breakouts or purging for oily skin?
This serum is unlikely to cause breakouts or purging for oily skin due to a good safety profile with no harsh ingredients. However, because it contains macadamia seed oil, an oily skin type needs a product with strong oil-controlling and balancing ingredients to properly manage shine.
Is this serum fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).
What the research says
Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects.
Colloids and Surfaces. B, Biointerfaces, 2025Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013
Why other serums fit oily skin better
A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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