Eighth Day Regenerative Serum for combination skin
Peptide-Rich Plasma
Sodium Hyaluronate
Niacinamide
Acetyl Glutamine
Manuka Honey
Average
- HighCombination Skin Fit
- AverageEffectiveness
- Low RiskSafety
Works for combination skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This serum offers excellent skin treatment for your combination skin, as multiple peptides like Sh-Oligopeptide-2 and Palmitoyl Tripeptide-5 support skin restoration and firmness, while niacinamide aids in barrier repair.
- Glycerin and Sodium Hyaluronate provide essential hydration to manage oily shine, though the inclusion of Glycolic Acid presents a moderate risk of irritation for your skin.
- The product is generally safe for your skin, with a low potential for adverse reactions.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.5Overall rating based on 300+ reviewsThis serum is highly praised for its "Peptide-Rich Plasma" technology, which users credit for rapidly improving skin texture, firmness, and radiance. While many describe it as a "holy grail" for anti-aging and hydration, a subset of users feel the high price tag is not justified by the results, which can be subtle for some.
Highlights
High price Mostly Mentioned
- “Very expensive ($325+)”
- “hefty price tag”
- “hard to justify”
- “investment skincare”
- “wallet-draining”
Fast absorption Often Mentioned
- “Lightweight, non-sticky, sinks in immediately, satin finish, layers well”
Visible anti-aging Often Mentioned
- “Smoother fine lines, plumper skin, increased firmness, brighter complexion, "instant glow."”
High-tech ingredients Sometimes Noted
- “Peptide-Rich Plasma, bio-identical actives, stem cell technology, clean formula, fragrance-free”
Hydration Sometimes Noted
- “Deeply hydrating, restores moisture barrier, skin feels bouncy, eliminates dryness”
Lack of results Sometimes Noted
- “No visible difference”
- “didn't work for me”
- “overhyped”
- “saw no change”
- “cheaper alternatives work better”
Packaging Rarely Noted
- “Sleek black bottle, airless pump, luxurious design, dispenses perfect amount”
Availability issues Rarely Noted
- “Frequently sold out”
- “hard to find”
- “waitlists”
- “stock issues”
No acne benefit Rarely Noted
- “Did not help breakouts”
- “didn't reduce acne”
- “neutral on blemishes”
Texture complaints Rarely Noted
- “Slightly tacky for some”
- “hard to spread (rare)”
- “leaves a film”
- “requires quick application”
Sources: lovi.care, nordstrom.com, violetgrey.com, editorialist.com, whowhatwear.com, reddit.com, and more
Questions and answers
How well does Eighth Day Regenerative Serum work for combination skin?
This serum works well for combination skin, as multiple peptides and niacinamide support firmness and help repair the skin barrier while sodium hyaluronate and glycerin provide hydration to manage oily shine. However, it is an average fit because the inclusion of glycolic acid presents a moderate risk of irritation. A product of this type needs effective ingredients like niacinamide, propolis, and zinc PCA that regulate oiliness, enhance radiance, and provide adequate hydration without any risk of irritation or unsuitability.
Clinical, Cosmetic and Investigational Dermatology, 2017Colloids and Surfaces. B, Biointerfaces, 2025
Which ingredients make this serum a good fit for combination skin?
This serum works well for combination skin because it contains peptides like palmitoyl tripeptide-5 that support firmness, alongside niacinamide, glycerin, and sodium hyaluronate which provide essential hydration and help manage oily shine. To be a better fit for this skin type, a product like this needs ingredients such as niacinamide, propolis, or zinc PCA that regulate oiliness and boost radiance without any risk of irritation.
Clinical, Cosmetic and Investigational Dermatology, 2017Colloids and Surfaces. B, Biointerfaces, 2025
What does Peptide-Rich Plasma do for combination skin?
Platelet-rich plasma helps improve skin elasticity and overall facial appearance when used for combination skin. To work best for this skin type, a product of this type needs nourishing growth factors and hydrating ingredients that balance oily and dry areas without clogging pores.
What does Hyaluronic Acid do for combination skin?
Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Dermatology and Therapy, 2021Journal of Drugs in Dermatology, 2011
Where does it go in a skincare routine for combination skin?
This treatment goes in the evening routine after cleansing and before moisturizing. Combination skin needs products with balancing hydrators like sodium hyaluronate and soothing ingredients like niacinamide to manage oily shine while supporting the skin barrier.
Can I use this serum with retinol, and in what order?
You can use this treatment with retinol by applying your retinol first at night and following with this serum, though the glycolic acid it contains may occasionally irritate your skin. Combination skin needs products that balance oil and hydration with soothing ingredients while keeping the risk of irritation low.
How often should I use it?
Use this serum in your evening routine once a week to start, and you may slowly use it more often if your skin tolerates it well. To work best for your combination skin, a product of this type needs soothing ingredients and gentle hydrators to manage oily shine while keeping the skin calm and smooth.
Clinical, Cosmetic and Investigational Dermatology, 2017Colloids and Surfaces. B, Biointerfaces, 2025
Can this serum clog pores, cause breakouts or purging for combination skin?
This serum is unlikely to clog pores or cause breakouts for combination skin, as it has a very low potential for adverse reactions. However, because it contains glycolic acid, it may occasionally cause mild irritation.
Clinical, Cosmetic and Investigational Dermatology, 2017Colloids and Surfaces. B, Biointerfaces, 2025
Is it fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects.
Colloids and Surfaces. B, Biointerfaces, 2025Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.
Antioxidants, 2021Topical insulin combined with fractional CO2 laser showed no significant difference in efficacy compared to topical PRP combined with fractional CO2 laser for atrophic acne scars in 30 patients.
Archives of Dermatological Research, 2025Subcision and microneedling combined with topical platelet-rich plasma resulted in significantly greater improvement in scar grading compared to subcision and microneedling alone in patients with atrophic scars.
Journal of Cutaneous and Aesthetic Surgery, 2024Platelets remain viable for up to 90 days in a refrigerated cosmetic vehicle with demonstrated topical clinical PRP facial benefits, and 20ml and 60ml PRP volumes are equally efficacious.
Journal of Drugs in Dermatology, 2020Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical overnight application of MGO Manuka Honey microemulsion eye cream significantly reduced symptomology, improved tear film stability and lipid layer thickness, and decreased lid margin staining, ocular Demodex, and bacterial load in patients with blepharitis compared to control eyes.
The Ocular Surface, 2020Optimel 16% manuka honey eye-drops significantly improved symptoms and objective signs in patients with meibomian gland dysfunction compared to baseline after 3 weeks.
The British Journal of Ophthalmology, 2022The application of Manuka honey and the GENADYNE A4 negative pressure wound therapy system in a 55-year-old woman with extensive phlegmonous and necrotic lesions following traumatic colonic rupture successfully enabled skin autografting and complete wound healing.
Medical Science Monitor, 2010
Ingredients
Water, Pentylene Glycol, Peptide-Rich Plasma, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Acetyl Glutamine, Sodium Hyaluronate, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Isoleucine, Phenylalanine, Taurine, Glycerin, Hedychium Coronarium Root Extract, Tripeptide-1, Polygonum Aviculare Extract, Honey, Nonapeptide-1, Acetyl Heptapeptide-4, Phytosphingosine, Sea Whip Extract, Niacinamide, Hydrolyzed Hyaluronic Acid, Aminobutyric Acid, Adenosine, Thioctic Acid, Glycolic Acid, Bacillus Soybean Folic Acid Extract Ferment, Polysorbate 20, Allantoin, Caprylyl Glycol, Lecithin, Butylene Glycol, 1,2-Hexanediol, Dextran, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.