CLEARSTEM HYDRAGLOW Moisturizer for mature skin

How to apply

Questions and answers

What the research says

• Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.

  The British Journal of Dermatology, 2019

• Treatment with a cream containing 5% alpha-lipoic acid for 12 weeks reduces skin roughness by an average of 50.8% compared to 40.7% with placebo in women with photoaged facial skin.

  The British Journal of Dermatology, 2003

• Application of 5% cubosomal alpha lipoic acid gel twice daily for 6 months significantly improved global aesthetic scores and increased epidermal thickness compared to placebo in 20 aging female faces.

  Journal of Cosmetic Dermatology, 2017

• Topical application of (-)-epigallocatechin-3-gallate (EGCG) to human skin before UV irradiation decreases UV-induced production of hydrogen peroxide by 68-90% and nitric oxide by 30-100%, inhibits leukocyte infiltration and lipid peroxidation by 41-84%, and restores glutathione levels and glutathione peroxidase activity compared to UV exposure alone.

  Carcinogenesis, 2001

• A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris.

  Clinical, Cosmetic and Investigational Dermatology, 2015

• Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days.

  Health Science Reports, 2025

• Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects.

  International Journal of Cosmetic Science, 2014

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties.

  Skin Pharmacology and Physiology, 2023

• Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models.

  Drug Discovery Today, 2017

• A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation.

  Saudi Pharmaceutical Journal, 2024

Ingredients

Water, Squalane, Propanediol, Cannabis Sativa Seed Oil, Punica Granatum Seed Oil, Polyglyceryl-6 Distearate, Glycerin, Cetyl Alcohol, Leuconostoc Radish Seed Extract, Bakuchiol, Aloe Barbadensis Leaf Extract, Sodium Hyaluronate, Jojoba Esters, Boswellia Carterii Oil, Camellia Sinensis Extract, Amino Acids, Argania Spinosa Extract Cell Stem Sprout Argan Extract Cell Stem Sprout, Curcuma Longa Root Extract, Essential Oil, Lactobacillus Ferment, Diglucosyl Gallic Acid, Alpha Lipoic Acid, Lactic Acid, Xanthan Gum, Caprylyl Glycol, Ethylhexylglycerin

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.