TIRTIR Ceramic Milk Ampoule for mature skin

How to apply

Questions and answers

What the research says

• Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.

  International Journal of Cosmetic Science, 2018

• Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events.

  Journal of Cosmetic Dermatology, 2019

• Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

  International Journal of Molecular Sciences, 2026

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• ANT1 soybean extract cream ameliorated complications and enhanced skin recovery after Nd:YAG laser therapy in 45 Asian women, with higher concentrations significantly reducing wrinkles, spots, and pores compared to placebo.

  Annals of Plastic Surgery, 2018

• Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity.

  International Journal of Pharmaceutics, 2008

• A phytoestrogen-enriched cosmetic formulation containing biotransformed soybean extract increased collagen-I expression in fibroblast cells and skin explants in an estrogen receptor beta-dependent manner without harming skin microbiota.

  Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas E Biologicas, 2023

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

Ingredients

Lactobacillus Soymilk Ferment Filtrate, Isopropyl Myristate, Polyglyceryl-2 Dipolyhydroxystearate, Rice Bran Oil, Polyglyceryl-4 Isostearate, Polyglyceryl-3 Ricinoleate, Glycerin, Butylene Glycol, Caprylic Capric Triglyceride, Niacinamide, Dimer Dilinoleyl Dimer Dilinoleate, 1,2-Hexanediol, Benzyl Glycol, Prunus Amygdalus Dulcis Seed Extract, Rice Extract, Avena Sativa Extract Oat Extract Meal Extract, Persea Gratissima Fruit Extract Avocado Fruit Extract, Maltodextrin, Water, Adenosine, Ethylhexylglycerin, Saccharomyces Viscum Album Extract Ferment Mistletoe Extract Ferment, Lactobacillus Soybean Extract Ferment, Squalane, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Saccharomyces Imperata Cylindrica Extract Root Ferment, Moringa Oleifera Seed Extract, Hydrogenated Lecithin, Collagen, Cetearyl Alcohol, Theobroma Cacao Extract, Pyrus Malus Leaf Extract, Vanilla Planifolia Fruit Extract, Leuconostoc Radish Root Ferment Filtrate, Stearic Acid, Strawberry Fruit Extract, Musa Sapientum Fruit Extract, Prunus Persica Fruit Extract, Propanediol, Coconut Oil, Prunus Domestica Fruit Extract, Ceramide Np, Cholesterol, Phytosphingosine, Ceramide Ng, Ceramide Ns, Ceramide, Ceramide Ap, Glycine, Glutamic Acid, Leucine, Methionine, Valine, Serine, Aspartic Acid, Alanine, Arginine, Isoleucine, Phenylalanine, Proline, Histidine, Taurine, Ornithine, Ceramide Eop

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.