Some By Mi Beta Panthenol Repair Cream for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

  Journal of Cosmetic Dermatology, 2017

• A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis.

  Journal of Cosmetic Dermatology, 2026

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.

  Archives of Facial Plastic Surgery, 2006

• A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.

  Cureus, 2024

• The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.

  Skin Research and Technology, 2026

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.

  European Journal of Neurology, 2013

• Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.

  Journal of Cosmetic and Laser Therapy, 2013

Ingredients

Water, Dipropylene Glycol, Propanediol, Methylpropanediol, Betaine, Octyldodecanol, 1,2-Hexanediol, Candida Bombicola Glucose Methyl Rapeseedate Fermented Product, Palmitic Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Glycerin, Stearic Acid, Squalane, Vinyl Dimethicone, Ammonium Acryloyldimethyltaurate Vp Copolymer, Jojoba Ester, Glyceryl Stearate, Stearyl Alcohol, Cetyl Alcohol, Polymethylsilsesquioxane, Phytosterols, Sunflower Wax Seed, Sodium Stearoyl Glutamate, Ethylhexylglycerin, Helianthus Annuus Seed Oil Sunflower Seed Oil, Hydroxyethylcellulose, Xanthan Gum, Dipotassium Glycyrrhizate, Hydrogenated Lecithin, Sorbitan Isostearate, Sorbitan Olivate, Adenosine, Cetearyl Olivate, Citric Acid, Musa Sapientum Fruit Extract, Rosa Damascena Flower Water, Sodium Phytate, Pyrus Communis Fruit Extract, Biosaccharide Gum-1, Prunus Domestica Fruit Extract, Cucumis Melo Fruit Extract, Carthamus Tinctorius Seed Oil, Butyrospermum Parkii Butter Shea Butter, Polyglycerin-3, Butylene Glycol, Hedera Helix Stem Extract Leaf, Disodium Phosphate, Sodium Phosphate, Tocopherol, Lactococcus Lysate Ferment, Bifida Lysate Ferment, Acetyl Hexapeptide-8, Lactobacillus Lysate Ferment, Copper Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4, Nonapeptide-1, Carnosine, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-5, Acetyl Tetrapeptide-2, Acetyl Octapeptide-3, Acetyl Tetrapeptide-3

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.