Clinique Even Better Clinical Dark Spot Corrector for skin with dark spots

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What the research says

• Treatment with ascorbyl glucoside-arginine complex lotion significantly decreased pigmentation scores and melanin index while increasing lightness in solar lentigos of Japanese females compared to placebo over 24 weeks.

  International Journal of Molecular Sciences, 2024

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• A dermo-cosmetic formula containing 2% enoxolone significantly reduced erythema at 24 hours and pain at 30 minutes following non-ablative fractional laser treatment in 10 healthy subjects compared to a moisturizer control.

  Journal of Cosmetic Dermatology, 2024

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties.

  Skin Pharmacology and Physiology, 2023

• Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models.

  Drug Discovery Today, 2017

• A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation.

  Saudi Pharmaceutical Journal, 2024

• Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients.

  CMAJ, 2010

• A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase.

  BioMed Research International, 2020

• Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy.

  Journal of Cosmetic Dermatology, 2024

• A single use of an alpha-tocopherol-enriched rinse-off product strongly increases alpha-tocopherol levels in skin barrier lipids maintained for at least 24 hours and significantly inhibits squalene photooxidation in human volunteers compared to a control product.

  Skin Pharmacology and Physiology, 2005

• The investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams showed no skin irritation and provided increased skin hydration and reduced transepidermal water loss in 76 healthy volunteers.

  Vojnosanitetski Pregled, 2016

• Topical treatment with a mixed RetinSphere - vitamin E formulation significantly decreased lipid peroxidation levels and oxidized squalene percentage, reduced interleukin-1α concentration in lesional areas, and led to clinical improvement in 18 patients with mild comedonal acne.

  Journal of the European Academy of Dermatology and Venereology, 2014

• Topical application of a cream containing 2.5% glycyrrhetinic acid significantly reduced thigh fat thickness and circumference compared to placebo in healthy women.

  Steroids, 2005

• Topical application of B-Resorcinol and Glycyrrhetinic acid effectively lightens hand solar lentigines after 4 weeks of treatment both with and without prior fractional laser photothermolysis, showing no statistical difference between the two approaches.

  Journal of Cosmetic Dermatology, 2016

• Glycyrrhetinic acid inhibited skin 11 beta-hydroxysteroid dehydrogenase and potentiated the vasoconstrictor action of hydrocortisone.

  Lancet, 1990

Ingredients

Water, Dimethicone, Isododecane, Cyclopentasiloxane, Polysilicone-11, Butylene Glycol, Ascorbyl Glucoside, Peg-10 Dimethicone, Curcuma Longa Root Extract, Rice Bran Extract, Grapefruit Peel Extract, Hordeum Vulgare Extract, Wheat Extract Germ Extract, Betula Alba Bark Extract, Cucumis Sativus Fruit Extract, Dimethoxytolyl Propylresorcinol, Scutellaria Baicalensis Root Extract, Morus Bombycis Root Extract Morus Alba Root Extract, Trametes Versicolor Extract, Saccharomyces Lysate Extract, Yeast Extract, Peg-6, Tromethamine, Salicylic Acid, Polysorbate 20, Cholesterol, Isohexadecane, Propylene Glycol Dicaprate, Helianthus Annuus Seedcake Sunflower Seedcake, Caffeine, Tocopheryl Acetate, Acetyl Glucosamine, Simethicone, Glycyrrhetinic Acid, Polysorbate 80, Sodium Hyaluronate, Di-C12-18 Alkyl Dimonium Chloride, Sodium Rna, Squalane, Sodium Sulfite, Sodium Metabisulfite, Caprylyl Glycol, Hexylene Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Disodium Edta, Phenoxyethanol, Ci 15985, Yellow 5 Ci 19140

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.