ISDIN and Azclear are respected skincare labels offering thoughtful formulations designed to gently nurture the complexion. The Spanish house founded in 1975 provides elegant moisturizers, advanced sunscreens, restorative serums , and targeted eye products, whereas the alternative is deeply appreciated for its soothing serums. Both brands suit sensitive and acne-prone skin best, though the former also cares for dry skin and the latter supports reactive skin types. They differ primarily in their standout solutions, with the first offering Fusion Water , Eryfotona Actinica, and K-Ox Eyes, and the second providing the Medicated Lotion.
ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.
puig.com beautymatter.com uploads.puig.com
This page compares some of the most popular ISDIN and Azclear products; for every product of both brands, with a fit score for your own skin, use the Lovi app .
Popular ISDIN vs Azclear products
Questions and answers
ISDIN or Azclear: which is better?
ISDIN is the better option for most shoppers, as the products on this page cover a wider variety of skin types and concerns with superior or high Lovi fit levels, whereas Azclear only offers a single medicated lotion.
What is the difference between ISDIN and Azclear?
ISDIN offers a larger range of products on this page with fragrance-free options like Eryfotona Actinica, whereas Azclear features only one product on this page, which contains no fragrance. ISDIN fits dry, sensitive, and acne-prone skin best, while Azclear fits oily acne-prone skin best.
Which is more affordable, ISDIN or Azclear?
Azclear is more affordable, whereas ISDIN is often noted for a high price point across the products on this page.
Which causes fewer breakouts, ISDIN or Azclear?
Azclear Medicated Lotion has a High Lovi fit for oily acne-prone skin, while the products on this page from ISDIN have a High fit for acne-prone skin.
Pharmaceutics, 2021
How do the founding years and parent companies of ISDIN and Azclear compare?
ISDIN was founded in 1975 in Spain and is owned by Puig, whereas Azclear was founded in 2010 and is owned by Ego Pharmaceuticals.
Which brand offers fragrance-free options across all its products, ISDIN or Azclear?
Azclear offers fragrance-free options across all the products on this page, whereas ISDIN lists fragrance in several of its formulas.
What specific skin types does ISDIN fit best according to its brand-focused routines?
According to its brand-focused routines, ISDIN fits dry skin, sensitive skin, and acne-prone skin best.
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Research behind their key ingredients
Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage
Antioxidants · Drug Delivery, 2017 Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022 Topical use of dexpanthenol in skin disorders
Panthenol · American Journal of Clinical Dermatology, 2002 Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020 Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Bakuchiol · The British Journal of Dermatology, 2019
36 more studies
Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial
Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018 Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Ascorbic acid · Journal of Cosmetic Dermatology, 2020 Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris
Azelaic acid · Pharmaceutics, 2021 The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021 A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol · The Journal of Dermatological Treatment, 2017 Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation
Tocopheryl acetate · Urologia Internationalis, 2019 A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid · BioMed Research International, 2020 Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024 Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc oxide · Journal of Controlled Release, 2025 Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid · Journal of Cosmetic Dermatology, 2024 Inhibition of TRPV1 prevented skin irritancy induced by phenoxyethanol. A preliminary in vitro and in vivo study
Phenoxyethanol · International Journal of Cosmetic Science, 2017 Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications
Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015 A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid · Journal of Drugs in Dermatology, 2023 Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris
Azelaic acid · Dermatology and Therapy, 2024 Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022 The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study
Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023 Comparison of methods for assessing photoprotection against ultraviolet A in vivo
Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987 Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters
Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019 Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide · Biomedicines, 2025 Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate · Arzneimittel-Forschung, 1998 Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters
Octocrylene · Antioxidants, 2025 Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol · Journal of Cosmetic Dermatology, 2025 TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection
Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023 Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026 Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation
Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023 Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate · Scientific Reports, 2025 Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022 Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride · Life, 2023 Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 Facial disbiosis and UV filters
Ethylhexyl salicylate · Archives of Dermatological Research, 2024 The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration
Lens esculenta seed extract · Journal of Cosmetic Dermatology, 2024 Retrospective Review of Dermal Safety Studies of Organic Sunscreens
Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025 Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026 Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking
Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026 Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population
Bakuchiol · Health Science Reports, 2025
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Behind this comparison
Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
Nadia Kapleva, MS
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
Alexey Shagraev, PhD
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
Aishani Shah, MD
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
Asya Zubkova, MS
Medical Board
Cosmetic chemist, SCS, IFSCC member
Hanna Kurets, MD
Medical Board, Medical Advisor
Dermatology MD
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist