Medicube Triple Collagen Serum for dry sensitive skin
Triple Collagen Complex
Sodium Hyaluronate
Niacinamide
AdenosineAverage
- HighDry Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for dry sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your dry skin, as Glycerin and Trehalose provide humectant action to hydrate and support flaky skin, but it lacks sufficient emollient ingredients for optimal results.
- The serum provides excellent plumping and firming benefits due to multiple forms of collagen and hyaluronic acid, which offer general skincare hydration.
- The safety profile is good, with no risks of irritation for your dry and sensitive skin due to the absence of harsh ingredients and the presence of soothing components like Glycerin and Collagen Extract.
How to apply
- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
People Say
★4.8Overall rating based on 200+ reviewsUsers frequently report this serum provides deep hydration, leading to a plumped, radiant complexion often described as 'glass skin'. It is well-loved for its smooth, non-greasy texture and effectiveness in diminishing fine lines, making it a great base for makeup. Some users find the fragrance to be strong and occasionally encounter issues with the packaging.
Highlights
Deep hydration Mostly Mentioned
- “Keeps skin hydrated even in depths of winter”
- “Skin feels nice and smooth”
- “Provides deep hydration.”
Glow and radiance Often Mentioned
- “Gives me glass skin”
- “Leaves a radiant glow”
- “Skin looks healthy and glowy.”
Good texture Sometimes Noted
- “Absorbs well without feeling sticky”
- “Silky texture”
- “Thick consistency but easy to apply.”
Plumping and anti-aging Sometimes Noted
- “Skin looks plumper”
- “Fine lines are diminished”
- “Improves skin elasticity.”
Packaging issues Sometimes Noted
- “Challenging to remove the cap”
- “Often taking the pump along with it”
- “Struggled to close it properly.”
Strong fragrance Sometimes Noted
- “Smells just a little bit cheap”
- “Contains fragrance”
- “Scent is a bit much.”
Makeup compatibility Rarely Noted
- “Layers beautifully under makeup”
- “Prevents makeup from looking cakey”
- “Perfect base for makeup.”
Skin sensitivity Rarely Noted
- “Caused small red bumps”
- “Feel a bit tingly”
- “Broke me out.”
Slightly sticky Rarely Noted
- “A bit sticky”
- “Can be a bit heavy”
- “Leaves a slight tack/film.”
Small quantity Rarely Noted
- “Amount is less than expected”
- “Use it up rather quickly”
- “Small bottle.”
Sources: lovi.care, iherb.com, yesstyle.com, olivekollection.com, beautybay.com, hikoco.co.nz, and more
Questions and answers
How well does Triple Collagen Serum work for dry sensitive skin?
Medicube Triple Collagen Serum provides moderate hydration for dry sensitive skin using glycerin and trehalose, but it lacks sufficient softening ingredients for optimal results. A product of this type needs rich moisturizing components and barrier-supporting ingredients like ceramides to properly care for dry sensitive skin.
Clinical, Cosmetic and Investigational Dermatology, 2017Skin Research and Technology, 2024
Which ingredients make this serum a good fit for dry sensitive skin?
Glycerin, trehalose, and multiple forms of collagen and hyaluronic acid make this serum a good fit by hydrating flaky skin and providing plumping benefits. However, because this product only offers moderate suitability for dry skin, a product of this type needs more nourishing, softening ingredients like ceramides and rich oils to lock in moisture and fully support your skin barrier.
Skin Research and Technology, 2024Clinical, Cosmetic and Investigational Dermatology, 2017
What does Triple Collagen do for dry sensitive skin?
Triple Collagen helps soothe dry sensitive skin by improving hydration, reducing roughness, and calming irritation. It supports the skin barrier to keep moisture locked in and makes the skin feel much softer.
What does Hyaluronic Acid do for dry sensitive skin?
Hyaluronic acid is a great fit for dry, sensitive skin because it brings a large boost in hydration, making the skin feel soft and smooth while improving barrier function. It helps calm tightness and dryness, and is unlikely to cause irritation.
Journal of Drugs in Dermatology, 2011Dermatology and Therapy, 2021
Where does this serum go in a skincare routine for dry sensitive skin?
This serum goes in your evening routine after your toner and before your moisturizer. To best care for dry skin, a product of this type needs rich smoothing and softening ingredients alongside hydration to keep flaky skin smooth and comfortable.
Can I use it with retinol, and in what order?
You can use this serum with retinol by applying the serum first to hydrate and soothe your skin, followed by your retinol product. This product works for dry and sensitive skin, but a product of this type needs extra rich, softening ingredients to properly seal in moisture.
How often should I use this serum?
You can use this serum in the evening as part of your routine. This helps hydrate and firm your dry skin, though this skin type needs extra softening ingredients for the best results.
Can it clog pores, cause breakouts or purging for dry sensitive skin?
Medicube Triple Collagen Serum is unlikely to clog pores, cause breakouts, or lead to purging for dry and sensitive skin. Its safety profile is good, with no harsh ingredients that typically trigger irritation on sensitive skin.
Is this serum fragrance-free and alcohol-free?
It contains fragrance (linalool and limonene) and drying alcohol (alcohol denat).
What the research says
Sodium trehalose sulfate decreased transepidermal water loss and increased stratum corneum water content in participants with low stratum corneum water content when applied for 4 weeks compared to placebo.
Skin Research and Technology, 2024A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Both oral and topical collagen supplements help delay the skin aging process by improving moisture, elasticity, and hydration, with no differences arising between the two types of collagen.
Dermatology Practical & Conceptual, 2022Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021
Why other serums fit dry sensitive skin better
Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks.
Journal of Cosmetic Dermatology, 2022In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle.
Skin Pharmacology and Physiology, 2026Hydrogels containing vitamin E-loaded nanostructured lipid carriers exhibited better occlusive properties and long-lasting effects, while vitamin E-loaded nanoemulsions performed a faster skin hydration effect and were selected as more attractive for skin application.
Colloids and Surfaces. B, Biointerfaces, 2019
Ingredients
Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 1,2-Hexanediol, Trehalose, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Atelocollagen, Desamido Collagen, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Cyclopentasiloxane, Hydroxypropyltrimonium Hyaluronate, Cyclohexasiloxane, Dimethicone, Benzyl Benzoate, Linalool, Limonene
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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