Medicube One Day Exosome Shot 7500 for oily skin
Lactobacillus Extracellular Vesicles
Niacinamide
Adenosine
Betaine Salicylate
Oenothera Biennis Flower Extract
Average
- HighOily Skin Fit
- AverageEffectiveness
- HighSafety
Works for oily skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your oily skin, as niacinamide and gluconolactone help regulate oil production and exfoliate pores, though ingredients like glycerin and panthenol provide general hydration that is less relevant to your primary concern of oily shine.
- The inclusion of Lactobacillus Extracellular Vesicles and Betaine Salicylate offers good support for improving skin texture and tone, but the overall formulation does not directly target the reduction of oily shine.
- The product is safe for your oily skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Panthenol.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
People Say
★4.6Overall rating based on 200+ reviewsUsers frequently report a "glass skin" effect with noticeable improvements in skin texture and pore size after overnight use, though the application involves a distinct prickly sensation due to the spicules. While highly effective for smoothing and tightening, it is polarizing due to the "needle-like" pain and potential for irritation on sensitive skin.
Highlights
Smoother skin texture Mostly Mentioned
- “bumpy texture became smoother”
- “skin feels just a touch more refined”
- “rough texture on my nose bridge improved”
Painful application Mostly Mentioned
- “feels like rubbing little needles”
- “owwie (but in a good way)”
- “very stingy, tingling feeling”
Fast/overnight results Often Mentioned
- “immediate boost in glow”
- “skin looked better the day after”
- “noticeable results after just one use”
Visible pore reduction Often Mentioned
- “enlarged pores were noticeably tightened”
- “pores look teeny tiny”
- “immediate and certain pore tightening”
Enhanced product absorption Sometimes Noted
- “makes all my serums work better”
- “products applied afterward absorbed faster”
- “liquid microneedling in a bottle”
Not for sensitive skin Sometimes Noted
- “wouldn't recommend for super sensitive skin”
- “irritation made the experience less enjoyable”
- “too strong for my barrier”
Skin irritation Sometimes Noted
- “skin became noticeably red and irritated”
- “led to redness and breakouts”
- “woke up with skin looking very pigmented”
High price point Rarely Noted
- “price point is a bit steep”
- “expensive”
- “fairly expensive for the amount”
Sources: lovi.care, ulta.com, iherb.com, stylekorean.com, oliveyoung.com, yesstyle.com, and more
Questions and answers
How well does Medicube Exosome Shot 7500 work for oily skin?
Medicube One Day Exosome Shot 7500 offers moderate benefits for oily skin because ingredients like niacinamide and gluconolactone help regulate oil and exfoliate pores. However, it includes heavy hydration that is less relevant to oily shine, so a treatment for this skin needs ingredients that specifically target excess oil, control sebum, and reduce enlarged pores alongside soothing and barrier-supporting components.
Skin Research and Technology, 2023American Journal of Clinical Dermatology, 2002
Which ingredients make this serum a good fit for oily skin?
Niacinamide and gluconolactone make this serum a good fit for oily skin because they help regulate oil production and exfoliate pores. A treatment of this type needs effective ingredients like niacinamide to control sebum production and manage oily shine, alongside soothing components and light hydration that keep the skin comfortable without clogging pores.
What do Lactobacillus Extracellular Vesicles do for oily skin?
Lactobacillus extracellular vesicles help calm irritated skin and support a balanced skin barrier. They are unlikely to clog pores and may reduce redness or inflammation in oily skin types.
Frontiers in Immunology, 2026International Journal of Biological Macromolecules, 2025
What does Niacinamide do for oily skin?
Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Journal of Cosmetic and Laser Therapy, 2006Antioxidants, 2021
Where does this serum go in a skincare routine for oily skin?
This treatment goes in the evening routine after cleansing and before your moisturizer. Oily skin works best with products that directly target excess oil control and pore clearing using ingredients like salicylic acid and niacinamide.
Can I use this serum with retinol, and in what order?
You can use this treatment with retinol by applying this product first and waiting for it to absorb before applying your retinol. This approach helps minimize potential irritation while allowing both ingredients to work effectively on your skin.
How often should I use this serum?
Start by using this treatment once a week in your evening routine, and if your skin tolerates it well and shows good results, you may carefully use it more often. This product of this type needs ingredients that directly target oil production and reduce oily shine to work best for oily skin.
Can this serum clog pores, cause breakouts or purging for oily skin?
This treatment is unlikely to clog pores or cause breakouts on oily skin, as it is safe with no harsh ingredients, though oily skin of this type needs targeted oil-controlling ingredients like niacinamide and salicylic acid to best manage shine.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Combining 10% gluconolactone chemical peeling with oxybrasion or microneedle mesotherapy increased skin hydration and decreased sebum, pH, and TEWL in twenty-one Caucasian women, with no significant differences between the two methods.
Skin Research and Technology, 2023Glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene showed no hindrance compared to adapalene monotherapy and provided benefits in reducing complications in 25 subjects with mild-to-moderate acne vulgaris.
Clinical, Cosmetic and Investigational Dermatology, 2019Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.
Journal of Cosmetic Dermatology, 2025A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport.
Biomaterials Advances, 2022A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides.
Medicina Cutanea Ibero-latino-americana, 1986Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models.
Metabolites, 2021
Why other serums fit oily skin better
Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.