Image Skincare Vital C Hydrating Enzyme Masque for skin with dark spots

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What the research says

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

• L-ascorbic acid 10% plus phytic acid 2% serum significantly reduced the pigmentation index of solar lentigines compared to a vehicle control in 30 healthy subjects.

  Journal of Cosmetic Dermatology, 2011

• Vitamin C mesotherapy produced a significant and earlier reduction in gingival pigmentation and higher patient satisfaction compared to topical gel in twenty healthy non-smokers with hyperpigmented gingiva, with both methods reducing the mean area fraction of melanin-forming cells at 6 months without causing pain.

  Clinical Oral Investigations, 2021

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Oral bromelain slightly reduced pain compared to controls (mean difference -0.27) and topical bromelain reduced time to complete debridement by 6.89 days, with no major health risks reported.

  Nutrition and Health, 2023

• An upcycled pineapple leaf fibre crosspolymer forms a physical barrier that protects against environmental aggressors while providing antioxidant, anti-inflammatory, antipollution, UV protection, hydration, and hair benefits.

  International Journal of Cosmetic Science, 2026

• A coaxial electrospun core-shell nanofiber scaffold delivering bromelain and salvianolic acid B demonstrated sustained drug release, in vitro endothelial cell migration, increased capillary formation in an in ovo assay, and in vivo efficacy for skin regeneration and wound healing.

  Biomedical Materials, 2017

• Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo.

  Wilderness & Environmental Medicine, 2016

• A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face.

  Giornale Italiano Di Dermatologia E Venereologia, 2015

• Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation.

  Molecules, 2020

• Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.

  European Journal of Pharmaceutics and Biopharmaceutics, 2016

• Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls.

  International Journal of Cosmetic Science, 2004

• Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable.

  European Journal of Pharmaceutics and Biopharmaceutics, 2007

Ingredients

Water, Carica Papaya Fruit Extract, Pineapple Fruit Extract, Glyceryl Stearate, Peg-100 Stearate, Ascorbic Acid, Sodium Hyaluronate, Phytic Acid, Retinyl Palmitate, Superoxide Dismutase, Algae Extract, Macrocystis Pyrifera Extract, Sodium Ascorbyl Phosphate, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Vitis Vinifera Seed Extract Grape Seed Extract, Yeast Polysaccharides, Tocopheryl Acetate, Sodium Rna, Potassium Sorbate, Citrus Aurantium Dulcis Extract Orange Blossom Extract, Silk Amino Acids, Sodium Dna, Disodium Edta

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.