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Pro-retinol and palmitoyl tripeptide-1

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Pro-retinol and palmitoyl tripeptide-1: keep them apart

Keep them apart

Use them at different times of day with pro-retinol at night and palmitoyl tripeptide-1 in the morning, because combining them can cause irritation. Both ingredients work hard to smooth the skin, and using them together can overwhelm your face. You can use a gentler product or wait longer between applying them.

Pro-retinol products

Palmitoyl tripeptide-1 products

Questions and answers

Can you use pro-retinol and palmitoyl tripeptide-1 together?

Keep pro-retinol and palmitoyl tripeptide-1 apart in your routine, as combining them may increase skin irritation. Instead, alternate their usage by applying your retinoid in the evening and peptides in the morning.

Which goes first, pro-retinol or palmitoyl tripeptide-1?

Keep pro-retinol and palmitoyl tripeptide-1 apart in your routine because combined stimulation may increase irritation. Alternate their usage by applying pro-retinol in the evening and palmitoyl tripeptide-1 in the morning.

Are pro-retinol and palmitoyl tripeptide-1 good for sensitive skin?

Keep pro-retinol and palmitoyl tripeptide-1 apart in your routine because combined stimulation may increase irritation, especially on sensitive skin. Alternate their usage by applying your retinoid at night and your peptides in the morning.

Research on pro-retinol and palmitoyl tripeptide-1

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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